公开(公告)号：US20130266479A1

公开(公告)日：2013-10-10

申请号：US13796939

申请日：2013-03-12

Applicant: ONDAVIA, INC.

Inventor： Mark C. Peterman ,  Merwan Benhabib ,  Benjamin A. Obrock

IPC: G01N21/65

CPC classification number: G01N21/658 ,  B01D57/02 ,  B01D61/427 ,  B01L3/502761

Abstract: A microfluidic separation device is provided that includes a first sample channel region and a second sample channel region, where the first sample channel region has an array of channels that are smaller than the second channel region, a first detection region and a second detection region located at the interface of the first sample channel region, a detection channel, an illuminating electric field, Raman-scattering nanoparticles having surface plasmon resonances for detection when illuminated by the electric field, where the resonances create an enhanced local electric field along specific directions resulting in an enhanced Raman response, and a nanoparticle input channel disposed to input the nanoparticles into the second sample channel region, where the nanoparticles are larger than the cross-section of the first sample channel region and the cross-section of the second detection region, where the nanoparticles collect in the first detection region to form region of densely packed nanoparticles.

Abstract translation: 提供了一种微流体分离装置，其包括第一样品通道区域和第二样品通道区域，其中第一样品通道区域具有小于第二通道区域的通道阵列，第一检测区域和第二检测区域 在第一样品通道区域的界面处，检测通道，照明电场，具有用于通过电场照射的检测的表面等离子体共振的拉曼散射纳米颗粒，其中共振沿着特定方向产生增强的局部电场，导致 增强的拉曼响应和纳米颗粒输入通道，其设置成将纳米颗粒输入到第二样品通道区域中，其中纳米颗粒大于第一样品通道区域的横截面和第二检测区域的横截面，其中 纳米颗粒在第一检测区域中收集以形成密集的区域 ed纳米颗粒。

公开(公告)号：US08999263B2

公开(公告)日：2015-04-07

申请号：US13796939

申请日：2013-03-12

Applicant: OndaVia, Inc.

Inventor： Mark C. Peterman ,  Merwan Benhabib ,  Benjamin A. Obrock

IPC: G01N21/65 ,  B01L3/00 ,  B01D57/02 ,  B01D61/42

CPC classification number: G01N21/658 ,  B01D57/02 ,  B01D61/427 ,  B01L3/502761

Abstract: A microfluidic separation device is provided that includes a first sample channel region and a second sample channel region, where the first sample channel region has an array of channels that are smaller than the second channel region, a first detection region and a second detection region located at the interface of the first sample channel region, a detection channel, an illuminating electric field, Raman-scattering nanoparticles having surface plasmon resonances for detection when illuminated by the electric field, where the resonances create an enhanced local electric field along specific directions resulting in an enhanced Raman response, and a nanoparticle input channel disposed to input the nanoparticles into the second sample channel region, where the nanoparticles are larger than the cross-section of the first sample channel region and the cross-section of the second detection region, where the nanoparticles collect in the first detection region to form region of densely packed nanoparticles.

Abstract translation: 提供了一种微流体分离装置，其包括第一样品通道区域和第二样品通道区域，其中第一样品通道区域具有小于第二通道区域的通道阵列，第一检测区域和第二检测区域 在第一样品通道区域的界面处，检测通道，照明电场，具有用于通过电场照射的检测的表面等离子体共振的拉曼散射纳米颗粒，其中共振沿着特定方向产生增强的局部电场，导致 增强的拉曼响应和纳米颗粒输入通道，其设置成将纳米颗粒输入到第二样品通道区域中，其中纳米颗粒大于第一样品通道区域的横截面和第二检测区域的横截面，其中 纳米颗粒在第一检测区域中收集以形成密集的区域 ed纳米颗粒。