公开(公告)号：US20200217838A1

公开(公告)日：2020-07-09

申请号：US16648708

申请日：2018-09-21

Applicant: OSAKA UNIVERSITY ,  MEIJI CO., LTD.

Inventor： Keisuke HAGIHARA ,  Kinya ASHIDA ,  Kentaro NAKAMURA

IPC: G01N33/50 ,  G01N33/574

Abstract: A method for selecting a cancer patient for whom a ketogenic diet therapy would be effective and a method for predicting efficacy of a ketogenic diet therapy in a cancer patient are provided. A method is characterized by obtaining a result of analysis of at least one pre-intake candidate substance selected from the group consisting of acylcarnitine(12:0), acylcarnitine(12:1)-2, acylcarnitine(12:1)-3, acylcarnitine(14:1)-1, acylcarnitine(14:2)-1, acylcarnitine(14:2)-2, acylcarnitine(14:3)-2, acylcarnitine(16:1), acylcarnitine(16:2), anandamide, heptadecenoic acid, hypotaurine, linoleylethanolamide, palmitoleic acid, palmitoylcarnitine, phytosphingosine, quinic acid, uric acid, alanine, citrulline, tryptophan and lysine in a serum derived from a cancer patient prior to intake of a ketogenic diet, and using the result of analysis as an indicator.

公开(公告)号：US20230085223A1

公开(公告)日：2023-03-16

申请号：US17768337

申请日：2020-10-13

Applicant: OSAKA UNIVERSITY

Inventor： Keisuke HAGIHARA ,  Katsufumi KAJIMOTO

IPC: A23L33/115

Abstract: The present invention provides a sugar-restricted, high-fat diet for improving liver disease. In the sugar-restricted, high-fat diet, daily fat intake may be set at 120 g or more based on a real body weight of 50 kg or set at an amount corresponding to 70% or more of the total daily energy intake. The sugar-restricted, high-fat diet can reduce body fat mass and AST, ALT, and γ-GTP levels in nonalcoholic fatty liver disease patients.

公开(公告)号：US20200147112A1

公开(公告)日：2020-05-14

申请号：US16587551

申请日：2019-09-30

Applicant: MEIJI CO., LTD. ,  THE NISSHIN OILLIO GROUP, LTD. ,  OSAKA UNIVERSITY

Inventor： Keisuke HAGIHARA ,  Noriyuki IKEDA ,  Kinya ASHIDA ,  Kentaro NAKAMURA

IPC: A61K31/7016 ,  A61K35/00 ,  A61K45/06

Abstract: An object of the present invention is to provide a diet therapy for suppressing tumor growth of refractory cancer, for treating refractory cancer, or for enhancing the effect of another cancer treatment. The present invention provides a saccharide restricted high fat composition for use in suppressing tumor growth of refractory cancer, treating refractory cancer and/or enhancing the effect of another cancer treatment. The composition of the present invention can comprise about 55% by mass or more of fat based on the total solid content contained in the composition. The composition of the present invention can also comprise about 0% by mass to about 15% by mass of saccharide based on the total solid content contained in the composition. The composition of the present invention can also comprise a medium chain fatty acid oil as fat.

公开(公告)号：US20220346427A1

公开(公告)日：2022-11-03

申请号：US17763366

申请日：2020-09-25

Applicant: OSAKA UNIVERSITY

Inventor： Keisuke HAGIHARA ,  Katsufumi KAJIMOTO

IPC: A23L33/12 ,  A23L33/17 ,  A23L33/00

Abstract: The present invention provides a sugar-restricted, high-fat diet for improving chronic kidney disease. In the sugar-restricted, high-fat diet, daily fat intake may be set at 120 g or more based on a real body weight of 50 kg or set at an amount corresponding to 70% or more of the total daily energy intake. The sugar-restricted, high-fat diet can increase glomerular filtration rate and reduce blood creatinine level in chronic kidney disease patients.

公开(公告)号：US20220283181A1

公开(公告)日：2022-09-08

申请号：US17624948

申请日：2020-07-07

Applicant: MEIJI CO., LTD. ,  THE NISSHIN OILLIO GROUP, LTD. ,  OSAKA UNIVERSITY

Inventor： Keisuke HAGIHARA ,  Satoshi OSAGA ,  Noriyuki IKEDA ,  Satoshi TAKASUGI ,  Kinya ASHIDA ,  Kentaro NAKAMURA

IPC: G01N33/68 ,  G01N33/66

Abstract: An object of the present invention is to provide a method for predicting prognosis for a cancer patient. The present invention provides a method for predicting prognosis for a cancer patient, wherein at least one index selected from the group consisting of an index of nutritional state, an index of sugar metabolism state, and an index of inflammatory state in the cancer patient is used as an index of prognosis. The index of nutritional state is preferably a concentration of albumin in the blood, the index of sugar metabolism state is preferably a concentration of glucose in the blood, and the index of inflammatory state is preferably a concentration of CRP in the blood.