公开(公告)号：US08594470B2

公开(公告)日：2013-11-26

申请号：US13888708

申请日：2013-05-07

Applicant: Palo Alto Research Center Incorporated

Inventor： Peter Kiesel ,  Oliver Schmidt

IPC: G02B6/00 ,  G02B6/04

CPC classification number: G02F1/29 ,  G01J1/42 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0216 ,  G01J3/0218 ,  G01J3/024 ,  G01J3/0256 ,  G01J3/26 ,  G01J3/2803 ,  G01J9/00 ,  G02B5/008 ,  G02B5/284 ,  G02B6/29317 ,  G02B6/4204 ,  G02B6/4298

Abstract: Input light, such as from an optical sensor or stimulus-wavelength converter, includes one or more light or dark sub-bands. The input light is transmitted, such as through a transmissive layer or transmission component, to obtain effects due to transmission with lateral variation. A detector can, for example, obtain spectral information or other photon energy information about the sub-bands due to lateral variation. For each light or dark sub-band, a transmission component can, for example, provide a respective light or dark spot, and spot position can be used to obtain spectral information such as absolute wavelength or wavelength change. A photosensing component can sense or detect transmitted light or output photons, such as with a photosensor array or a position-sensitive detector. Circuitry can use photosensed quantities to obtain, e.g. a differential signal or information about time of wavelength change.

Abstract translation: 诸如来自光学传感器或刺激波长转换器的输入光包括一个或多个浅或暗的子带。 传输输入光，例如通过透射层或透射分量，以获得由于具有横向变化的透射而产生的影响。 检测器可以例如由于横向变化而获得关于子带的光谱信息或其他光子能量信息。 对于每个光或暗子带，透射分量可以例如提供相应的光斑或暗点，并且光斑位置可用于获得诸如绝对波长或波长变化的光谱信息。 感光组件可以感测或检测透射光或输出光子，例如用光电传感器阵列或位置敏感检测器。 电路可以使用光照量来获得，例如。 差分信号或有关波长变化时间的信息。

公开(公告)号：US20130240706A1

公开(公告)日：2013-09-19

申请号：US13888708

申请日：2013-05-07

Applicant: PALO ALTO RESEARCH CENTER INCORPORATED

Inventor： Peter Kiesel ,  Oliver Schmidt

IPC: G02F1/29 ,  G01J1/42

CPC classification number: G02F1/29 ,  G01J1/42 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0216 ,  G01J3/0218 ,  G01J3/024 ,  G01J3/0256 ,  G01J3/26 ,  G01J3/2803 ,  G01J9/00 ,  G02B5/008 ,  G02B5/284 ,  G02B6/29317 ,  G02B6/4204 ,  G02B6/4298

Abstract: Input light, such as from an optical sensor or stimulus-wavelength converter, includes one or more light or dark sub-bands. The input light is transmitted, such as through a transmissive layer or transmission component, to obtain effects due to transmission with lateral variation. A detector can, for example, obtain spectral information or other photon energy information about the sub-bands due to lateral variation. For each light or dark sub-band, a transmission component can, for example, provide a respective light or dark spot, and spot position can be used to obtain spectral information such as absolute wavelength or wavelength change. A photosensing component can sense or detect transmitted light or output photons, such as with a photosensor array or a position-sensitive detector. Circuitry can use photosensed quantities to obtain, e.g. a differential signal or information about time of wavelength change.

公开(公告)号：US20140370612A1

公开(公告)日：2014-12-18

申请号：US14474742

申请日：2014-09-02

Applicant: Palo Alto Research Center Incorporated

Inventor： Michael Bassler ,  Peter Kiesel ,  Oliver Schmidt ,  Noble M. Johnson

IPC: G01N21/64

CPC classification number: G01N21/6486 ,  G01N15/1427 ,  G01N15/147 ,  G01N2015/1447 ,  G01N2015/1454 ,  Y10T436/143333 ,  Y10T436/17

Abstract: A method and system for using spatially modulated excitation/emission and relative movement between a particle (cell, molecule, aerosol, . . . ) and an excitation/emission pattern are provided. In at least one form, an interference pattern of the excitation light with submicron periodicity perpendicular to the particle flow is used. As the particle moves along the pattern, emission is modulated according to the speed of the particle and the periodicity of the stripe pattern. A single detector, which records the emission over a couple of stripes, can be used. The signal is recorded with a fast detector read-out in order to capture the “blinking” of the particles while they are moving through the excitation pattern. This concept enables light detection with high signal-to-noise ratio and high spatial resolution without the need of expensive and bulky optics.

Abstract translation: 提供了使用空间调制的激发/发射和颗粒（细胞，分子，气溶胶等）和激发/发射图案之间的相对运动的方法和系统。 在至少一种形式中，使用具有垂直于颗粒流的亚微米周期的激发光的干涉图案。 当颗粒沿着图案移动时，根据颗粒的速度和条纹图案的周期性来调制发射。 可以使用记录两条条纹上的发射的单个检测器。 用快速检测器读出来记录信号，以便在它们移动通过激励图案时捕获颗粒的“闪烁”。 这个概念能够实现高信噪比和高空间分辨率的光检测，而不需要昂贵和庞大的光学元件。

公开(公告)号：US09638637B2

公开(公告)日：2017-05-02

申请号：US14474742

申请日：2014-09-02

Applicant: Palo Alto Research Center Incorporated

Inventor： Michael Bassler ,  Peter Kiesel ,  Oliver Schmidt ,  Noble M. Johnson

IPC: G01N15/10 ,  G01N21/64 ,  G01N15/14

CPC classification number: G01N21/6486 ,  G01N15/1427 ,  G01N15/147 ,  G01N2015/1447 ,  G01N2015/1454 ,  Y10T436/143333 ,  Y10T436/17

Abstract: A method and system for using spatially modulated excitation/emission and relative movement between a particle (cell, molecule, aerosol, . . . ) and an excitation/emission pattern are provided. In at least one form, an interference pattern of the excitation light with submicron periodicity perpendicular to the particle flow is used. As the particle moves along the pattern, emission is modulated according to the speed of the particle and the periodicity of the stripe pattern. A single detector, which records the emission over a couple of stripes, can be used. The signal is recorded with a fast detector read-out in order to capture the “blinking” of the particles while they are moving through the excitation pattern. This concept enables light detection with high signal-to-noise ratio and high spatial resolution without the need of expensive and bulky optics.