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    DUAL-MODE MICROFLUIDIC GENETICS TESTING PLATFORMS AND METHODS OF DUAL-MODE GENETICS TESTING USING SAME
    1.
    发明申请
    DUAL-MODE MICROFLUIDIC GENETICS TESTING PLATFORMS AND METHODS OF DUAL-MODE GENETICS TESTING USING SAME 审中-公开
    双模式微流感遗传测试平台和使用其的双模式遗传测试方法

    公开(公告)号：US20150330900A1

    公开(公告)日：2015-11-19

    申请号：US14808476

    申请日：2015-07-24

    Applicant: PATHWAY GENOMICS CORPORATION

    Inventor： Tanya Moreno ,  Cindy Wang ,  David Becker

    IPC: G01N21/64

    CPC classification number: G01N21/6428 ,  B01L7/52 ,  G01N21/6452 ,  G01N2201/061

    Abstract: Dual mode genetics testing systems are devised about a single element testing platform. A microfluidic network and system of interconnected receiving cells and reaction vessels supports at the same time genotyping and copy number analysis where the platform may be subject to a common thermal cycle schedule to cause the proper reactions (DNA replication) necessary in both test types. Further, the microfluidic platform which includes reaction vessels for genotyping which are spatially removed from reaction vessels for copy number analysis, is coupled to optical scanner and detection systems specifically arranged to apply test specific detection routines on each of these distinct regions or portions of the dual mode test platform.

    Abstract translation: 关于单个元素测试平台设计了双模式遗传学测试系统。 互连接收细胞和反应容器的微流体网络和系统同时支持基因分型和拷贝数分析，其中平台可能经受常见的热循环进程，以引起两种测试类型中必需的适当反应（DNA复制）。 此外，包括用于基因分型的反应容器的微流体平台被从用于拷贝数分析的反应容器中空间移除，被耦合到光学扫描器和检测系统，该系统被特别设置为在这些不同区域或双重部分的每一个上应用测试特异性检测程序 模式测试平台。

    SALIVA SAMPLE COLLECTION SYSTEMS
    2.
    发明申请
    SALIVA SAMPLE COLLECTION SYSTEMS 有权
    SALIVA样品收集系统

    公开(公告)号：US20140205516A1

    公开(公告)日：2014-07-24

    申请号：US14137395

    申请日：2013-12-20

    Applicant: PATHWAY GENOMICS CORPORATION

    Inventor： James Plante ,  David Becker ,  Edgar MacBean ,  Kathryn J. Elliott

    IPC: C12Q1/68

    CPC classification number: C12Q1/6806 ,  A61B10/0051 ,  A61B10/0096 ,  A61B2010/0006 ,  B01L3/50825 ,  B01L2200/18 ,  B01L2300/044 ,  B01L2300/047 ,  B01L2300/0672 ,  B01L2300/0832 ,  B01L2300/0858 ,  B01L2300/0867 ,  Y10T436/2575

    Abstract: Saliva sample collection systems are configured with special attention to ease-of-use for the unskilled user and safe transport and delivery by a conventional delivery services such as Federal Express. A sealed cavity is formed by tight coupling of two primary elements: a receiving vessel element and a sealing cap element. The receiving vessel has integrated therewith: a standing means, a fill-line window, a funnel system, a knife, a threadset, and containment tube among others. A complementary cap element includes a cooperating threadset, label receiving surface, gripping surface, seal means and reservoir with piercable thin-film membrane. These two primary elements may be accommodated in an application-specific shipping container which support two shipping modes whereby the system may be shipped safely to and from a donor user each way in a different shipping mode.

    Abstract translation: 唾液样本收集系统被配置为特别注意非熟练用户的易用性，并通过常规传送服务（如联邦快递）进行安全的传输和传送。 通过紧密耦合两个主要元件形成密封空腔：接收容器元件和密封帽元件。 接收容器与其结合：立式装置，填充线窗，漏斗系统，刀，螺纹组和容纳管等。 互补盖元件包括协作螺纹组件，标签接收表面，抓握表面，密封装置和具有可撕裂薄膜膜的储存器。 这两个主要元件可以容纳在特定于应用的运输容器中，其支持两种运送模式，由此系统可以以不同的运送模式每次以方式运送给和来自捐赠者的用户。

    GENETIC SAMPLE COLLECTION SYSTEMS
    3.
    发明申请
    GENETIC SAMPLE COLLECTION SYSTEMS 审中-公开
    遗传样本收集系统

    公开(公告)号：US20150251176A1

    公开(公告)日：2015-09-10

    申请号：US14717997

    申请日：2015-05-20

    Applicant: PATHWAY GENOMICS CORPORATION

    Inventor： David Becker ,  James Plante ,  Tanya Moreno ,  Cindy Wang

    IPC: B01L3/00 ,  C12Q1/68 ,  C12N15/10 ,  B01L99/00

    CPC classification number: B01L3/508 ,  A61B10/0051 ,  A61B10/0096 ,  A61B2010/0006 ,  B01L3/502 ,  B01L3/50825 ,  B01L99/00 ,  B01L2200/185 ,  B01L2300/042 ,  B01L2300/044 ,  B01L2300/047 ,  B01L2300/06 ,  B01L2300/0672 ,  C12N15/1006 ,  C12Q1/6806

    Abstract: Biological sample collection kits are devised with physical features to enable a high performance collection system which delivers preprocessed biological matter via conventional shipping means to a testing laboratories. In particular, untrained and unskilled users deposit biological matter such as saliva or blood into a receiving vessel. By sealing the container, the user causes release of a premixed solution containing preservatives and optionally lysis reagents. In addition, a purification agent is arranged to bind to target molecules and facilitate their removal from solution. These time consuming processes occur while the sample is in transit to the testing facility such that when it arrives, it is in a preconditioned state immediately ready for execution of washing steps. Thus, the high performance containers taught herein are useful for collection biological samples and performing initial process steps on received matter—steps which are largely effected during the shipping stage of the transfer process.

    Abstract translation: 生物样本收集套件设计有物理特征，以实现高性能收集系统，其通过常规运输方式将预处理的生物物质提供给测试实验室。 特别是，未经训练和不熟练的使用者将诸如唾液或血液的生物物质沉积到接收容器中。 通过密封容器，使用者引起含有防腐剂和任选裂解试剂的预混溶液的释放。 此外，将净化剂配置成与靶分子结合并促进它们从溶液中的去除。 这些耗时的过程发生在样品转运到测试设备时，使得当其到达时，它处于预处理状态，立即准备好执行洗涤步骤。 因此，本文中教导的高性能容器对于收集生物样品是有用的，并且在接收的物质步骤上执行初始的处理步骤，这些步骤主要是在转移过程的运输阶段中实现的。

    GENOMICS-BASED ALERTING SYSTEMS
    4.
    发明申请
    GENOMICS-BASED ALERTING SYSTEMS 审中-公开
    基于基因的报警系统

    公开(公告)号：US20160026772A1

    公开(公告)日：2016-01-28

    申请号：US14871728

    申请日：2015-09-30

    Applicant: PATHWAY GENOMICS CORPORATION

    Inventor： James Plante ,  David Becker

    IPC: G06F19/00 ,  G06F17/30

    CPC classification number: G06F16/245 ,  G06Q10/00 ,  G16H50/30 ,  G16H50/70

    Abstract: Alerting systems include mechanical chemical systems for analyzing a human DNA samples to produce a genomic data set representing genetic indicators or markers on alleles of interest including those as well SNPs associated with important trial traits disease and characteristics. A genome dataset is stored as a portion of a data a record having a one-to-one correspondence with membership in a membership database. A dynamic rule that provides a query engine with logic which can be executed against membership data stored in accordance with standardized database procedures to produce a genomic result set from which appropriate alerts may be formed in a computer apparatus. These alerts may be characterized as including multimedia information and they may be prefer to play conveyed to membership with whom the underlying data is associated.

    Abstract translation: 警报系统包括用于分析人类DNA样品的机械化学系统，以产生代表感兴趣的等位基因的遗传指标或标记的基因组数据集，包括与重要的试验性状疾病和特征相关的SNP。 基因组数据集作为数据的一部分存储在与成员数据库中的隶属关系一一对应的记录上。 一种动态规则，其向查询引擎提供可根据标准化数据库过程存储的会员数据执行的逻辑，以产生可在计算机设备中形成适当警报的基因组结果集。 这些警报可以被表征为包括多媒体信息，并且他们可能更喜欢播放传达给与基础数据相关联的会员。

    Saliva sample collection systems
    5.
    发明授权
    Saliva sample collection systems 有权
    唾液样本收集系统

    公开(公告)号：US08932539B2

    公开(公告)日：2015-01-13

    申请号：US14137395

    申请日：2013-12-20

    Applicant: Pathway Genomics Corporation

    Inventor： James Plante ,  David Becker ,  Edgar MacBean ,  Kathryn J. Elliott

    IPC: B01L3/00 ,  C12Q1/68

    CPC classification number: C12Q1/6806 ,  A61B10/0051 ,  A61B10/0096 ,  A61B2010/0006 ,  B01L3/50825 ,  B01L2200/18 ,  B01L2300/044 ,  B01L2300/047 ,  B01L2300/0672 ,  B01L2300/0832 ,  B01L2300/0858 ,  B01L2300/0867 ,  Y10T436/2575

    Abstract: Saliva sample collection systems are configured with special attention to ease-of-use for the unskilled user and safe transport and delivery by a conventional delivery services such as Federal Express. A sealed cavity is formed by tight coupling of two primary elements: a receiving vessel element and a sealing cap element. The receiving vessel has integrated therewith: a standing means, a fill-line window, a funnel system, a knife, a threadset, and containment tube among others. A complementary cap element includes a cooperating threadset, label receiving surface, gripping surface, seal means and reservoir with piercable thin-film membrane. These two primary elements may be accommodated in an application-specific shipping container which support two shipping modes whereby the system may be shipped safely to and from a donor user each way in a different shipping mode.

    Abstract translation: 唾液样本收集系统被配置为特别注意非熟练用户的易用性，并通过常规传送服务（如联邦快递）进行安全的传输和传送。 通过紧密耦合两个主要元件形成密封空腔：接收容器元件和密封帽元件。 接收容器与其结合：立式装置，填充线窗，漏斗系统，刀，螺纹组和容纳管等。 互补盖元件包括协作螺纹组件，标签接收表面，抓握表面，密封装置和具有可撕裂薄膜膜的储存器。 这两个主要元件可以容纳在特定于应用的运输容器中，其支持两种运送模式，由此系统可以以不同的运送模式每次以方式运送给和来自捐赠者的用户。

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