公开(公告)号：US09290496B2

公开(公告)日：2016-03-22

申请号：US14548749

申请日：2014-11-20

Applicant: PFIZER INC.

Inventor： Douglas Carl Behenna ,  Hengmiao Cheng ,  Sujin Cho-Schultz ,  Theodore Otto Johnson, Jr. ,  John Charles Kath ,  Asako Nagata ,  Sajiv Krishnan Nair ,  Simon Paul Planken

IPC: A61K31/519 ,  C07D473/18 ,  A61P35/00 ,  A61K31/5377 ,  C07D498/10 ,  A61K31/5386 ,  C07D487/04 ,  A61K31/52 ,  C07D473/16 ,  C07D519/00

CPC classification number: C07D473/16 ,  A61K31/519 ,  A61K31/52 ,  A61K31/5377 ,  A61K31/5386 ,  C07D473/18 ,  C07D519/00

Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein Q, G, ring A, ring B, R1, R2, R3, R4, R5, R5a, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, R20, R21, R22, R23, R24, and m are defined herein. The novel purine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. Additional embodiments relate to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.

Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，其中Q，G，环A，环B，R1，R2，R3，R4，R5，R5a，R6，R7，R8，R9， R 11，R 12，R 13，R 14，R 15，R 16，R 17，R 18，R 19，R 20，R 21，R 22，R 23，R 24和m如本文所定义。 新型嘌呤衍生物可用于治疗哺乳动物中异常细胞生长，如癌症。 另外的实施方案涉及含有化合物的药物组合物和使用化合物和组合物治疗哺乳动物异常细胞生长的方法。

公开(公告)号：US10662204B2

公开(公告)日：2020-05-26

申请号：US16263185

申请日：2019-01-31

Applicant: PFIZER INC.

Inventor： Simon Planken ,  Hengmiao Cheng ,  Michael Raymond Collins ,  Jillian Elyse Spangler ,  Alexei Brooun ,  Andreas Maderna ,  Cynthia Palmer ,  Maria Angelica Linton ,  Asako Nagata ,  Ping Chen

IPC: C07D403/12 ,  C07D403/14 ,  C07D407/14 ,  C07D487/10 ,  A61P35/00 ,  C07D519/00 ,  C07D471/04 ,  C07D487/04 ,  C07D417/14 ,  C07D413/14 ,  A61P25/00

Abstract: Compounds of the general formula: processes for the preparation of these compounds, compositions containing these compounds, and administration of these compounds to patients to treat pancreatic, lung, colon and other cancers.

公开(公告)号：US10590115B2

公开(公告)日：2020-03-17

申请号：US16265012

申请日：2019-02-01

Applicant: PFIZER INC.

Inventor： Simon Planken ,  Hengmiao Cheng ,  Michael Raymond Collins ,  Jillian Elyse Spangler ,  Alexei Brooun ,  Andreas Maderna ,  Cynthia Palmer ,  Maria Angelica Linton ,  Asako Nagata ,  Ping Chen

IPC: C07D403/14 ,  C07D487/10 ,  A61P35/00 ,  C07D403/04 ,  C07D239/94

Abstract: Compounds of the general formula: processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

公开(公告)号：US09758538B2

公开(公告)日：2017-09-12

申请号：US15209574

申请日：2016-07-13

Applicant: PFIZER INC.

Inventor： Ping Chen ,  Hengmiao Cheng ,  Gary Michael Gallego ,  Mehran Jalaie ,  John Charles Kath ,  Suvi Tuula Marjukka Orr ,  Mason Alan Pairish

IPC: C07F9/6558 ,  C07D401/14 ,  C07D413/14 ,  C07D403/14 ,  C07D405/14 ,  A61K31/5377 ,  C07D401/04 ,  C07D403/04

CPC classification number: C07F9/65583 ,  A61K31/5377 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14

Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein X, Y, Z, R1-R11, m, n, and p are defined herein. The novel pyrimidine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. Additional embodiments relate to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.

公开(公告)号：US09260439B2

公开(公告)日：2016-02-16

申请号：US14677112

申请日：2015-04-02

Applicant: PFIZER INC.

Inventor： Ping Chen ,  Hengmiao Cheng ,  Judith Gail Deal ,  Gary Michael Gallego ,  Mehran Jalaie ,  John Charles Kath ,  Suvi Tuula Marjukka Orr ,  Hong Shen ,  Luke Raymond Zehnder

IPC: A61K31/5377 ,  C07D487/04 ,  C07F9/6561 ,  A61K45/06 ,  A61N5/10

CPC classification number: C07D487/04 ,  A61K31/5377 ,  A61K45/06 ,  A61N5/10 ,  C07F9/65616

Abstract: The present invention relates to compounds of formula (X) or pharmaceutically acceptable salts thereof, wherein R1-R50, a, b, d, e, f, g, h, i, j, k, l, o, p, q, r, s, t, u, y, and z are defined herein. The novel dihydropyrrolopyrimidine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. Additional embodiments relate to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.

Abstract translation: 本发明涉及式（X）化合物或其药学上可接受的盐，其中R 1 -R 50，a，b，d，e，f，g，h，i，j，k，l，o，p，q， r，s，t，u，y和z在本文中定义。 新型二氢吡咯并嘧啶衍生物可用于治疗哺乳动物中异常细胞生长，如癌症。 另外的实施方案涉及含有化合物的药物组合物和使用化合物和组合物治疗哺乳动物异常细胞生长的方法。

公开(公告)号：US20150141402A1

公开(公告)日：2015-05-21

申请号：US14548749

申请日：2014-11-20

Applicant: PFIZER INC.

Inventor： Douglas Carl Behenna ,  Hengmiao Cheng ,  Sujin Cho-Schultz ,  Theodore Otto Johnson, JR. ,  John Charles Kath ,  Asako Nagata ,  Sajiv Krishnan Nair ,  Simon Paul Planken

IPC: C07D473/16

CPC classification number: C07D473/16 ,  A61K31/519 ,  A61K31/52 ,  A61K31/5377 ,  A61K31/5386 ,  C07D473/18 ,  C07D519/00

Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein Q, G, ring A, ring B, R1, R2, R3, R4, R5, R5a, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, R20, R21, R22, R23, R24, and m are defined herein. The novel purine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. Additional embodiments relate to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.

Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，其中Q，G，环A，环B，R1，R2，R3，R4，R5，R5a，R6，R7，R8，R9， R 11，R 12，R 13，R 14，R 15，R 16，R 17，R 18，R 19，R 20，R 21，R 22，R 23，R 24和m如本文所定义。 新型嘌呤衍生物可用于治疗哺乳动物中异常细胞生长，如癌症。 另外的实施方案涉及含有化合物的药物组合物和使用化合物和组合物治疗哺乳动物异常细胞生长的方法。