公开(公告)号：US09398876B2

公开(公告)日：2016-07-26

申请号：US13713189

申请日：2012-12-13

Applicant: PHARMACOPHOTONICS, INC.

Inventor： Exing Wang ,  Daniel Meier ,  Robert Bunch ,  Bruce Molitoris ,  Ruben Sandoval ,  Matthew Rubin

IPC: A61B5/1455 ,  A61B5/20 ,  A61B5/00 ,  A61K49/00 ,  A61B1/00 ,  A61M5/00

CPC classification number: A61B5/201 ,  A61B1/00154 ,  A61B1/00165 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/412 ,  A61B5/6852 ,  A61K49/0017 ,  A61M5/007

Abstract: A method for measuring a glomerular filtration rate in a mammalian kidney comprises a source of reporter and marker fluorescent molecules. The fluorescent molecules are introduced into the blood stream of a mammalian subject. Over a period of time, a measurement of the intensities of the reporter and marker fluorescent molecules is taken. A ratio is calculated to determine the health of the subject's kidney. This method measures volume of plasma distribution based on a fluorescence of a marker molecule relative to a fluorescence of a reporter molecule.

Abstract translation: 用于测量哺乳动物肾脏中肾小球滤过率的方法包括报告物和标记物荧光分子的来源。 将荧光分子引入哺乳动物受试者的血液中。 在一段时间内，测量报告物和标记荧光分子的强度。 计算比例以确定受试者的肾脏的健康状况。 该方法基于标记分子的荧光相对于报告分子的荧光测量血浆分布的体积。

公开(公告)号：US20170014065A1

公开(公告)日：2017-01-19

申请号：US15218417

申请日：2016-07-25

Applicant: PharmacoPhotonics, Inc. d/b/a FAST BioMedical

Inventor： Exing Wang ,  Daniel Meier ,  Robert Bunch ,  Bruce Molitoris ,  Ruben Sandoval ,  Matthew Rubin

IPC: A61B5/20 ,  A61K49/00 ,  A61B5/00

CPC classification number: A61B5/201 ,  A61B1/00154 ,  A61B1/00165 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/412 ,  A61B5/6852 ,  A61K49/0017 ,  A61M5/007

Abstract: A method for measuring a glomerular filtration rate in a mammalian kidney comprises a source of reporter and marker fluorescent molecules. The fluorescent molecules are introduced into the blood stream of a mammalian subject. Over a period of time, a measurement of the intensities of the reporter and marker fluorescent molecules is taken. A ratio is calculated to determine the health of the subject's kidney. This method measures volume of plasma distribution based on a fluorescence of a marker molecule relative to a fluorescence of a reporter molecule.

Abstract translation: 用于测量哺乳动物肾脏中肾小球滤过率的方法包括报告物和标记物荧光分子的来源。 将荧光分子引入哺乳动物受试者的血液中。 在一段时间内，测量报告物和标记荧光分子的强度。 计算比例以确定受试者的肾脏的健康状况。 该方法基于标记分子的荧光相对于报告分子的荧光测量血浆分布的体积。

公开(公告)号：US20140050667A1

公开(公告)日：2014-02-20

申请号：US14062123

申请日：2013-10-24

Applicant: PHARMACOPHOTONICS, INC. D/B/A FAST DIAGNOSTICS

Inventor： Exing Wang ,  Daniel Meier ,  Robert Bunch ,  Bruce Molitoris ,  Ruben Sandoval ,  Matthew Rubin

IPC: A61K49/00

CPC classification number: A61K49/0043 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/201 ,  A61B5/412 ,  A61K49/0017 ,  A61K49/0054

Abstract: A method for measuring a glomerular filtration rate in a mammalian kidney comprises a source of reporter and marker fluorescent molecules. The fluorescent molecules are introduced into the blood stream of a mammalian subject. Over a period of time, a measurement of the intensities of the reporter and marker fluorescent molecules is taken. A ratio is calculated to determine the health of the subject's kidney. This method measures volume of plasma distribution based on a fluorescence of a marker molecule relative to a fluorescence of a reporter molecule.

Abstract translation: 用于测量哺乳动物肾脏中肾小球滤过率的方法包括报告物和标记物荧光分子的来源。 将荧光分子引入哺乳动物受试者的血液中。 在一段时间内，测量报告物和标记荧光分子的强度。 计算比例以确定受试者的肾脏的健康状况。 该方法基于标记分子的荧光相对于报告分子的荧光测量血浆分布的体积。

公开(公告)号：US09814788B2

公开(公告)日：2017-11-14

申请号：US14062123

申请日：2013-10-24

Applicant: PHARMACOPHOTONICS, INC.

Inventor： Exing Wang ,  Daniel Meier ,  Robert Bunch ,  Bruce Molitoris ,  Ruben Sandoval ,  Matthew Rubin

IPC: A61B10/00 ,  A61B5/00 ,  A61B8/00 ,  A61K49/00 ,  A61B5/20

CPC classification number: A61K49/0043 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/201 ,  A61B5/412 ,  A61K49/0017 ,  A61K49/0054

Abstract: A method for measuring a glomerular filtration rate in a mammalian kidney comprises a source of reporter and marker fluorescent molecules. The fluorescent molecules are introduced into the blood stream of a mammalian subject. Over a period of time, a measurement of the intensities of the reporter and marker fluorescent molecules is taken. A ratio is calculated to determine the health of the subject's kidney. This method measures volume of plasma distribution based on a fluorescence of a marker molecule relative to a fluorescence of a reporter molecule.

公开(公告)号：US20220354403A1

公开(公告)日：2022-11-10

申请号：US17728026

申请日：2022-04-25

Applicant: PHARMACOPHOTONICS, INC.

Inventor： Exing Wang ,  Daniel Meier ,  Robert Bunch ,  Bruce Molitoris ,  Ruben Sandoval ,  Matthew Rubin

IPC: A61B5/20 ,  A61B5/00 ,  A61K49/00 ,  A61B1/00 ,  A61M5/00

Abstract: A method for measuring a glomerular filtration rate in a mammalian kidney comprises a source of reporter and marker fluorescent molecules. The fluorescent molecules are introduced into the blood stream of a mammalian subject. Over a period of time, a measurement of the intensities of the reporter and marker fluorescent molecules is taken. A ratio is calculated to determine the health of the subject's kidney. This method measures volume of plasma distribution based on a fluorescence of a marker molecule relative to a fluorescence of a reporter molecule.

公开(公告)号：US11337629B2

公开(公告)日：2022-05-24

申请号：US16692490

申请日：2019-11-22

Applicant: PHARMACOPHOTONICS, INC.

Inventor： Exing Wang ,  Daniel Meier ,  Robert Bunch ,  Bruce Molitoris ,  Ruben Sandoval ,  Matthew Rubin

IPC: A61B5/1455 ,  A61B5/20 ,  A61B5/00 ,  A61K49/00 ,  A61B1/00 ,  A61M5/00

Abstract: A method for measuring a glomerular filtration rate in a mammalian kidney comprises a source of reporter and marker fluorescent molecules. The fluorescent molecules are introduced into the blood stream of a mammalian subject. Over a period of time, a measurement of the intensities of the reporter and marker fluorescent molecules is taken. A ratio is calculated to determine the health of the subject's kidney. This method measures volume of plasma distribution based on a fluorescence of a marker molecule relative to a fluorescence of a reporter molecule.

公开(公告)号：US20130116518A1

公开(公告)日：2013-05-09

申请号：US13713189

申请日：2012-12-13

Applicant: PHARMACOPHOTONICS, INC. D/B/A FAST DIAGNOSTICS

Inventor： Exing Wang ,  Daniel Meier ,  Robert Bunch ,  Bruce Molitoris ,  Ruben Sandoval ,  Matthew Rubin

IPC: A61B5/20 ,  A61M5/00 ,  A61B1/00 ,  A61B5/00

CPC classification number: A61B5/201 ,  A61B1/00154 ,  A61B1/00165 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/412 ,  A61B5/6852 ,  A61K49/0017 ,  A61M5/007

Abstract: A method for measuring a glomerular filtration rate in a mammalian kidney comprises a source of reporter and marker fluorescent molecules. The fluorescent molecules are introduced into the blood stream of a mammalian subject. Over a period of time, a measurement of the intensities of the reporter and marker fluorescent molecules is taken. A ratio is calculated to determine the health of the subject's kidney. This method measures volume of plasma distribution based on a fluorescence of a marker molecule relative to a fluorescence of a reporter molecule.

Abstract translation: 用于测量哺乳动物肾脏中肾小球滤过率的方法包括报告物和标记物荧光分子的来源。 将荧光分子引入哺乳动物受试者的血液中。 在一段时间内，测量报告物和标记荧光分子的强度。 计算比例以确定受试者的肾脏的健康状况。 该方法基于标记分子的荧光相对于报告分子的荧光测量血浆分布的体积。