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公开(公告)号：US20240117039A1
公开(公告)日：2024-04-11
申请号：US18384223
申请日：2023-10-26
Applicant: Prothena Biosciences Limited
Inventor： Andriani Ioannou , Tarlochan S. Nijjar , Philip James Dolan, III , Wagner Zago
IPC: C07K16/28
CPC classification number: C07K16/28 , C07K2317/24 , C07K2317/565 , C07K2317/76
Abstract: The invention provides antibodies that specifically bind sortilin. The antibodies inhibit or delay pathologies associated with changes in progranulin levels and associated symptomatic deterioration.
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公开(公告)号：US12049497B2
公开(公告)日：2024-07-30
申请号：US18384223
申请日：2023-10-26
Applicant: Prothena Biosciences Limited
Inventor： Andriani Ioannou , Tarlochan S. Nijjar , Philip James Dolan, III , Wagner Zago
IPC: C07K16/28
CPC classification number: C07K16/28 , C07K2317/24 , C07K2317/565 , C07K2317/76
Abstract: The invention provides antibodies that specifically bind sortilin. The antibodies inhibit or delay pathologies associated with changes in progranulin levels and associated symptomatic deterioration.
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公开(公告)号：US20230355756A1
公开(公告)日：2023-11-09
申请号：US18245533
申请日：2021-08-06
Applicant: PROTHENA BIOSCIENCES LIMITED
Inventor： Robin Barbour , Gene Kinney , Wagner Zago
IPC: A61P37/04 , A61K39/395
CPC classification number: A61K39/3955 , A61P37/04 , A61K2039/6037
Abstract: The disclosure provides peptide compositions and immunotherapy compositions comprising alpha-synuclein peptide. The disclosure also provides methods of treating or effecting prophylaxis of neurodegenerative diseases, such as Parkinson’s disease, dementia with Lewy bodies (DLB), Alzheimer’s disease or other synucleinopathies, with alpha-synuclein deposition in a subject, including methods of clearing deposits, inhibiting or reducing aggregation of alpha-synuclein, blocking the uptake by neurons and inhibiting propagation of alpha-synuclein seeds in a subject having or at risk of developing a neurodegenerative disease containing alpha-synuclein accumulations. The methods include administering to such patients the compositions comprising alpha-synuclein peptide.
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公开(公告)号：US20230348588A1
公开(公告)日：2023-11-02
申请号：US18145588
申请日：2022-12-22
Applicant: Prothena Biosciences Limited
Inventor： Philip James Dolan, III , Andriani Ioannou , Wagner Zago , Tarlochan S. Nijjar
IPC: C07K16/28
CPC classification number: C07K16/28 , C07K2317/24 , C07K2317/565 , C07K2317/71
Abstract: The invention provides antibodies that specifically bind sortilin. The antibodies inhibit or delay pathologies associated with changes in progranulin levels and associated symptomatic deterioration.
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Patent Agency Ranking
公开(公告)号：US20240117040A1
公开(公告)日：2024-04-11
申请号：US18384230
申请日：2023-10-26
Applicant: Prothena Biosciences Limited
Inventor： Andriani Ioannou , Tarlochan S. Nijjar , Philip James Dolan, III , Wagner Zago
IPC: C07K16/28
CPC classification number: C07K16/28 , C07K2317/24 , C07K2317/565 , C07K2317/76
Abstract: The invention provides antibodies that specifically bind sortilin. The antibodies inhibit or delay pathologies associated with changes in progranulin levels and associated symptomatic deterioration.
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公开(公告)号：US20220213223A1
公开(公告)日：2022-07-07
申请号：US17429876
申请日：2019-12-16
Applicant: Prothena Biosciences Limited , Tufts Medical Center, In.
Inventor： Raymond Comenzo , Wagner Zago , Nina Mrcedes Ashton
Abstract: Treatment of AL Amyloidosis with the Combination of Monoclonal Antibodies against immunoglobulin Light Chains and Aggregates of Immunoglobulin Light Chains and the CD38 Cell Membrane Molecule on Antibody-Producing and Other Immune Cells.
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公开(公告)号：US20250084153A1
公开(公告)日：2025-03-13
申请号：US18273854
申请日：2022-01-29
Applicant: Prothena Biosciences Limited
Inventor： Gene Kinney , Wagner Zago , Radhika Tripuraneni , Carol Karp
Abstract: Antibody formulations and methods useful for treatment of patients with AL amyloidosis.
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公开(公告)号：US12084491B2
公开(公告)日：2024-09-10
申请号：US17471526
申请日：2021-09-10
Applicant: PROTHENA BIOSCIENCES LIMITED , HOFFMANN-LA ROCHE INC.
Inventor： Gennaro Pagano , Wagner Zago
Abstract: The invention provides a method of treating, preventing or ameliorating Parkinson's disease with Prasinezumab.
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公开(公告)号：US12049498B2
公开(公告)日：2024-07-30
申请号：US18384230
申请日：2023-10-26
Applicant: Prothena Biosciences Limited
Inventor： Andriani Ioannou , Tarlochan S. Nijjar , Philip James Dolan, III , Wagner Zago
IPC: C07K16/28
CPC classification number: C07K16/28 , C07K2317/24 , C07K2317/565 , C07K2317/76
Abstract: The invention provides antibodies that specifically bind sortilin. The antibodies inhibit or delay pathologies associated with changes in progranulin levels and associated symptomatic deterioration.
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