公开(公告)号：US20240335570A1

公开(公告)日：2024-10-10

申请号：US18560675

申请日：2022-05-13

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Philip LOW ,  Madduri SRINIVASARAO ,  Spencer LINDEMAN ,  Spencer GARDEEN

IPC: A61K51/04 ,  A61B6/00 ,  A61K49/00 ,  A61K51/08 ,  A61P35/00

CPC classification number: A61K51/0497 ,  A61K49/0032 ,  A61K51/088 ,  A61P35/00 ,  A61B6/481

Abstract: A conjugate of formula (I) FRTL-BBMecL-AA or (II) FRTL-Alb-BBMecL-AA, wherein FRTL is a folate receptor-targeting ligand, BBMecL is a brush border membrane (BBM) enzyme-cleavable linker, Alb is an albumin-binder moiety, and AA is an active agent; composition comprising same; and method of imaging and/or treating a tumor.

公开(公告)号：US20240285776A1

公开(公告)日：2024-08-29

申请号：US18560670

申请日：2022-05-13

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Philip LOW ,  Imrul SHAHRIAR

IPC: A61K47/55 ,  A61P31/16

CPC classification number: A61K47/55 ,  A61P31/16

Abstract: A conjugate of formula EVTsmL-L-AMRL, wherein EVTsmL is an enveloped virus-targeting, small molecule ligand, AMRL is an activated macrophage-recruiting ligand, and L is a linker that is covalently bound to EVTsmL and AMRL; a composition comprising the same; and a method of using the conjugate or composition to treat (therapeutically or prophylactically) a viral infection.

公开(公告)号：US20240058478A1

公开(公告)日：2024-02-22

申请号：US18260598

申请日：2022-01-06

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Spencer S. GARDEEN ,  Seth HERR ,  Philip LOW ,  Riyi SHI

IPC: A61K49/00 ,  A61K47/55 ,  A61K31/095 ,  A61P25/00

CPC classification number: A61K49/0032 ,  A61K47/551 ,  A61K49/0052 ,  A61K31/095 ,  A61P25/00

Abstract: A conjugate comprising a ligand that targets a folate receptor linked to an acrolein scavenger drug; a composition comprising same; a method of using the conjugate or the composition to scavenge acrolein, alone or in further combination with other reactive aldehyde species, in a subject with neurotrauma; and a method of delivering an acrolein scavenger or an imaging agent to the central nervous system (CNS) of a patient with inflammation in the CNS.

公开(公告)号：US20150320799A1

公开(公告)日：2015-11-12

申请号：US14654227

申请日：2013-12-20

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Philip LOW ,  Haiyan CHU ,  Yong Gu LEE

IPC: A61K35/17 ,  A61K47/48

Abstract: Cytotoxic lymphocytes expressing chimeric antigen receptors (CAR) that target and bind small conjugate molecules (SCM) are disclosed, as well as methods of using the cells and the SCMs in the treatment of cancer.

Abstract translation: 公开了靶向和结合小共轭分子（SCM）的表达嵌合抗原受体（CAR）的细胞毒性淋巴细胞，以及将细胞和SCM用于治疗癌症的方法。