公开(公告)号：US20140046196A1

公开(公告)日：2014-02-13

申请号：US13964722

申请日：2013-08-12

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Young L. KIM ,  Raymond L. KONGER ,  Ally-Khan SOMANI ,  Zhengbin XU

IPC: A61B5/00

CPC classification number: A61B5/0075 ,  A61B5/02007

Abstract: An apparatus and method of mesoscopic imaging which provide improved contrast to changes in tumor microenvironments are disclosed. The apparatus includes a light which illuminates tissue in vivo, a spectrometer which varies at least one parameter of the light, and optics which transmit light backscattered from the tissue. The optics comprise any one of (i) a small aperture 4-focal length (4-f) lens system within an angular cone of 2°-5°, (ii) a telecentric lens, and (iii) an anti-scatter grid and a camera lens.

Abstract translation: 公开了一种提供与肿瘤微环境变化的对比度的介观成像装置和方法。 该装置包括在体内照射组织的光，改变光的至少一个参数的光谱仪和从组织反射散射光的光学器件。 光学元件包括（i）2°-5°的角锥内的小孔4-焦距（4-f）透镜系统，（ii）远心透镜，和（iii）防散射栅格 和相机镜头。