公开(公告)号：US08018079B2

公开(公告)日：2011-09-13

申请号：US12390503

申请日：2009-02-23

Applicant: Patrick D. Kelly

Inventor： Patrick D. Kelly

IPC: F02B63/04

CPC classification number: F03D5/04 ,  F03D9/11 ,  F03D9/25 ,  F05B2240/921 ,  F05B2240/922 ,  F05B2240/98 ,  Y02B10/30 ,  Y02E10/70 ,  Y02E10/72

Abstract: An electric generating system uses a zeppelin filled with helium or hydrogen, and a spinnaker sail, to provide pulling power that will lift a heavy railcar to an elevated height on a track, such as on a hill or mountainside, or in an elevator-type shaft in a tall building. When the heavy car reaches the top of the track, it is released, and its descent drives an electric generator. The generator can be carried by the car, and can send the power to batteries on the car, or to conductive rails. Alternately, if the car is inert weight, cables can drive stationary generators. The zeppelin will be inflated and deflated repeatedly, using equipment to recapture energy during each gas expansion, to help drive subsequent recompression into high-pressure tanks. The spinnaker sail will use a cable-handling device and spreader bars to deploy the sail and keep it at an elevated height. Various advantages are provided compared to wind turbines and pumped-storage hydroelectric facilities.

Abstract translation: 发电系统使用填充有氦气或氢气的三角帆飞船和三角帆风帆，以提供将重型轨道车升至高度的牵引力，例如在山坡或山腰上或电梯型 轴在一个高大的建筑物。 当重型汽车到达轨道顶部时，它被释放，其下降驱动发电机。 发电机可以由汽车携带，并可以将电力发送到汽车上的电池或导电轨道上。 或者，如果汽车是惰性的，电缆可以驱动静态发电机。 使用设备在每个气体膨胀期间重新捕获能量，使飞船重新充气和放气，以帮助推动后续的压缩进入高压坦克。 三角帆帆船将使用电缆处理装置和吊具杆部署风帆并将其保持在高架高度。 与风力涡轮机和抽水蓄能水电设施相比，提供了各种优点。

公开(公告)号：US5599551A

公开(公告)日：1997-02-04

申请号：US361967

申请日：1994-12-22

Applicant: Patrick D. Kelly

Inventor： Patrick D. Kelly

IPC: A61K9/00 ,  A61K31/315 ,  A61K33/30 ,  A61K7/40 ,  A01N55/02 ,  A61K31/325

CPC classification number: A61K33/30 ,  A61K31/315 ,  A61K9/0034 ,  Y10S514/886 ,  Y10S514/931 ,  Y10S514/934 ,  Y10S514/944 ,  Y10S514/966 ,  Y10S514/967 ,  Y10S514/968 ,  Y10S514/969

Abstract: This invention relates to an article of manufacture comprising an aqueous gel containing a selected zinc salt contained within a deformable plastic-walled tubular container, for convenient and consistent use as a topical genital lubricant during acts of sexual intercourse. The zinc salt must be organic, water-soluble, and have substantial dissociation rates to release divalent zinc ions. Suitable zinc salts include zinc acetate, zinc propionate, zinc butyrate, zinc formate, zinc gluconate, zinc glycerate, zinc glycolate, and zinc lactate. The gel must also contain a thickening agent (such as chemically treated cellulose) and a lubricating agent (such as glycerin), and it must be free of heparin, dextran sulfate, or any other anti-coagulant or other component which poses a substantial risk of adverse effects if the lubricant is used frequently and repeatedly over a period of months or years. The zinc-containing lubricants described herein can reduce the risk that a previously uninfected person will become infected by genital herpes viruses, and possibly by HIV, hepatitis, or papilloma viruses or other sexually transmitted pathogens, during or after intercourse with an infected partner.

Abstract translation: 本发明涉及一种制品，其包含含有可变形塑料壁管状容器中所含的选择的锌盐的含水凝胶，用于在性交行为期间方便和一致地用作局部生殖润滑剂。 锌盐必须是有机的，水溶性的，并且具有显着的解离速率以释放二价锌离子。 合适的锌盐包括乙酸锌，丙酸锌，丁酸锌，甲酸锌，葡糖酸锌，甘油酸锌，乙醇酸锌和乳酸锌。 凝胶还必须含有增稠剂（如化学处理的纤维素）和润滑剂（如甘油），并且必须不含肝素，硫酸葡聚糖或任何具有重大危险的其他抗凝血剂或其他成分 如果在几个月或几年的时间内经常和多次使用润滑剂，则会产生不利影响。 本文所述的含锌润滑剂可以降低以前未感染的人在与受感染的伴侣之间或之后发生的生殖器疱疹病毒以及可能由艾滋病毒，肝炎或乳头瘤病毒或其他性传播病原体感染的风险。

公开(公告)号：US06696071B2

公开(公告)日：2004-02-24

申请号：US10001045

申请日：2001-11-27

Applicant: Patrick D. Kelly

Inventor： Patrick D. Kelly

IPC: A01N2504

CPC classification number: A61K33/30

Abstract: An aqueous douche or enema is disclosed, containing a water-soluble zinc salt at an anti-viral concentration, designed for use shortly before and/or shortly after intercourse. Unlike a lubricant for use during intercourse, this type of rinsing liquid will not contain glycerine or similar lubricating components, and will be designed to not leave behind a film-type residue. However, this type of “pericoital” rinse (i.e., intended for pre-coital or post-coital use) will leave behind positively-charged zinc ions. Due to electrostatic attraction, these Zn++ ions will cling to negatively-charged canyons and other “binding sites” in proteins that are exposed and accessible on the surfaces of cells and virus particles. The binding of Zn++ ions to negatively-charged sites in these surface proteins will alter and disrupt the ability of viruses (including herpes and HIV) to bind to and infect human cells. Accordingly, this type of rinse can reduce the risk of infection by sexually transmitted viruses, in a person who is not previously infected. In addition, due to the skin-protective properties of zinc, a pericoital rinse containing a water-soluble zinc salt can help accelerate the healing and closure of microabrasions, lesions, and other breaches or deficits in genital skin or mucous membranes, thereby further decreasing the risk of viral infections following intercourse.

Abstract translation: 公开了含有水溶性灌洗液或灌肠剂，其含有抗病毒浓度的水溶性锌盐，其设计用于在性交之前和/或性交后不久使用。 与在性交中使用的润滑剂不同，这种类型的冲洗液体将不含甘油或类似的润滑组分，并且将被设计成不留下薄膜型残留物。 然而，这种类型的“pericoital”冲洗（即用于前置或后置使用）将留下带正电的锌离子。 由于静电吸引，这些Zn ++离子将粘附到带电荷的峡谷和蛋白质中的其他“结合位点”，这些蛋白质在细胞和病毒颗粒的表面上暴露和可及。 Zn ++离子与这些表面蛋白中的带负电荷位点的结合会改变和破坏病毒（包括疱疹和HIV）结合和感染人类细胞的能力。 因此，这种类型的冲洗可以在以前未被感染的人中降低性传播病毒感染的风险。 另外，由于锌的皮肤保护性能，含有水溶性锌盐的渗透性漂洗可有助于加速微生物，损伤和其他破坏或生殖器皮肤或粘膜缺陷的愈合和闭合，从而进一步减少 性交后病毒感染的风险。

公开(公告)号：US5785054A

公开(公告)日：1998-07-28

申请号：US464273

申请日：1995-06-05

Applicant: Patrick D. Kelly

Inventor： Patrick D. Kelly

IPC: A61K33/30 ,  A61F6/02

CPC classification number: A61K33/30

Abstract: This invention relates to an article of manufacture including a genital lubricant containing a selected non-irritating, water-soluble zinc salt at an anti-viral concentration, within a package that is provided with a label indicating that the lubricant is effective as an anti-viral agent against at least one type of sexually transmitted virus (such as genital herpes viruses, human immunodeficiency viruses, hepatitis viruses, or papilloma viruses). One such lubricant includes a lubricant gel in a plastic-walled tubular package, for use with or without a condom; another such lubricant includes a condom lubricant, coated on a condom and sealed along with the condom inside a disposable plastic pouch. The zinc salt must be water-soluble and have substantial dissociation rates to release divalent zinc ions, and the lubricant must not cause genital irritation or other adverse effects, even if used repeatedly over a period of months or years. The zinc-containing lubricants described herein can reduce the risk that a previously uninfected person will become infected by sexually transmitted viruses, and the labelling information will help promote efficacy and slow the spread of incurable viruses.

Abstract translation: 本发明涉及一种包含生物润滑剂的制品，其包含在包装内含有抗病毒浓度的所选择的非刺激性水溶性锌盐，所述包装中具有指示该润滑剂作为抗 - 针对至少一种类型的性传播病毒（如生殖器疱疹病毒，人类免疫缺陷病毒，肝炎病毒或乳头瘤病毒）的病毒剂。 一种这样的润滑剂包括在塑料壁管状包装中的润滑剂凝胶，用于或不使用避孕套; 另一种这样的润滑剂包括涂覆在避孕套上的避孕套润滑剂并与一次性塑料袋内的避孕套一起密封。 锌盐必须是水溶性的，具有明显的解离速率以释放二价锌离子，润滑剂不得引起生殖器刺激或其他副作用，即使反复使用数月或数年。 本文所述的含锌润滑剂可以降低先前未感染的人将被性传播的病毒感染的风险，并且标签信息将有助于促进不可治愈病毒的功效并减缓其传播。

公开(公告)号：US20130052014A1

公开(公告)日：2013-02-28

申请号：US13218445

申请日：2011-08-25

Applicant: Patrick D. Kelly

Inventor： Patrick D. Kelly

IPC: F03D5/00

CPC classification number: F03D5/00 ,  F03D5/04 ,  Y02E10/70

Abstract: New types of “airborne spinnaker sails” are disclosed, made from high-strength straps that are interwoven in a manner that preserves open space between them. These devices, referred to as “webbing sails” or simply “web sails”, are designed for use in conjunction with buoyant lifting devices, to capture and harvest wind energy in a way which will generate large mechanical pulling forces, which can be used to drive electric power generators. These types of web sails are designed to operate in winds that exceed 100 or even 150 miles per hour.

Abstract translation: 公开了新型的机载三角帆风帆，由高强度带构成，它们以保持它们之间的开放空间的方式交织在一起。 被称为织带帆或简单的腹板的这些装置被设计成与浮力提升装置一起使用，以产生大的机械拉力的方式捕获和收获风能，这可以用于驱动发电机 。 这些类型的网帆设计为在每小时超过100甚至150英里的风中操作。

公开(公告)号：US20080141596A1

公开(公告)日：2008-06-19

申请号：US11613188

申请日：2006-12-19

Applicant: Patrick D. Kelly ,  Robert Peoples

Inventor： Patrick D. Kelly ,  Robert Peoples

IPC: E04B2/74

CPC classification number: E04H9/14 ,  Y02A50/14

Abstract: Sloping panel assemblies are disclosed, for protecting coastal homes and other buildings against hurricanes or very high winds. Long waterproof panels with widths up to 12 feet, made with fibers from recycled carpets, can be rapidly affixed to anchoring devices that have been shallowly buried around the periphery of a building. After anchoring, the panels will lean against the eave of a building, creating an enclosed pyramid-like structure capped by the roof of the building. Wedge-shaped nose and tail sections can similarly be affixed to the ends of A-frame buildings. Hinged cover panels, over drainage trenches, can be raised and locked at a sloped angle, to provide windbreaks and floodwater drainage on the windward sides of coastal buildings.

Abstract translation: 公开了倾斜面板组件，用于保护沿海住宅和其他建筑物免受飓风或非常大的风。 宽度高达12英尺的长防水面板，由回收地毯的纤维制成，可以快速地固定在浅埋在建筑物周边的锚固装置上。 锚固后，面板将靠在建筑物的屋檐上，形成一个封闭的金字塔状结构，由建筑物的屋顶盖住。 楔形的鼻翼和尾部也可以类似地贴在A框架建筑物的末端。 铰链盖板，排水沟可以倾斜倾斜抬起和锁定，在沿海建筑物的上风侧提供防风林和洪水排水。

公开(公告)号：US5208031A

公开(公告)日：1993-05-04

申请号：US737169

申请日：1991-07-29

Applicant: Patrick D. Kelly

Inventor： Patrick D. Kelly

IPC: A61K9/00 ,  A61K31/315 ,  A61K33/30

CPC classification number: A61K33/30 ,  A61K31/315 ,  A61K9/0034 ,  Y10S514/886 ,  Y10S514/931 ,  Y10S514/934 ,  Y10S514/944 ,  Y10S514/966 ,  Y10S514/967 ,  Y10S514/968 ,  Y10S514/969

Abstract: This invention relates to the use of zinc salts as anti-viral agents in sexual lubricants. A zinc salt which releases divalent zinc ions in an aqueous carrier fluid is provided in a sexual lubricant formulation which is spread on the genitals before sexual intercourse. The mixture is non-irritating, and the zinc ions serve as an anti-viral agent to reduce the risk of contracting genital herpes if a sexual partner is infected. These lubricants may also reduce the risk of infection by other sexually transmitted viral diseases, such as hepatitis, papilloma viruses, and AIDS. A preferred lubricant formulation comprises water, a thickening or suspending agent, a lubricating agent, and a suitable zinc salt. Salts which have been tested and shown to be non-irritating during sexual intercourse include zinc acetate, zinc propionate, and zinc gluconate. Other zinc salts have also been identified which are soluble in water and have low pK values, which indicates a high rate of zinc ion release.

Abstract translation: 本发明涉及在性润滑剂中锌盐作为抗病毒剂的用途。 在水性载体流体中释放二价锌离子的锌盐被提供在性润滑剂制剂中，其在性交前在生殖器上传播。 该混合物是无刺激性的，并且锌离子作为抗病毒剂，以降低性伴侣感染生殖器疱疹的风险。 这些润滑剂也可能降低其他性传播病毒性疾病如肝炎，乳头瘤病毒和艾滋病感染的风险。 优选的润滑剂制剂包含水，增稠剂或悬浮剂，润滑剂和合适的锌盐。 已经测试并显示在性交时不刺激的盐包括醋酸锌，丙酸锌和葡萄糖酸锌。 还已经鉴定出其它可溶于水并且具有低pK值的锌盐，这表明锌离子释放率高。

公开(公告)号：USD478806S1

公开(公告)日：2003-08-26

申请号：US29074411

申请日：1997-08-05

Applicant: William P. McDonough ,  Patrick D. Kelly

Designer： William P. McDonough ,  Patrick D. Kelly

公开(公告)号：US5980477A

公开(公告)日：1999-11-09

申请号：US122595

申请日：1998-07-25

Applicant: Patrick D. Kelly

Inventor： Patrick D. Kelly

IPC: A61K31/765 ,  A61K33/30 ,  A61F13/00

CPC classification number: A61K31/765 ,  A61K33/30

Abstract: This invention relates to the use of water-soluble zinc salts as anti-viral agents in genital lubricants (such as condom lubricants or stand-alone gels), to reduce the risk of infection by sexually transmitted viruses. Such zinc-containing anti-viral lubricants can be spread on the shaft of the penis or inside the vagina before sexual intercourse, or applied in other suitable manners that causes the lubricant fluid to be coated on one or more genital surfaces during intercourse. These lubricants also can be sealed in watertight packages containing lubricated condoms, or packaged and sold as "stand-alone" lubricants in watertight containers without condoms. Preferred lubricants contain a water-soluble lubricating agent, such as glycerin or polyethylene glycol, and a suitable zinc salt, and water, to promote ionization of the salt and release of zinc ions (Zn.sup.++). Such lubricants may also contain a thickening or suspending agent, such as a cellulose derivative, a natural gum compound, or a hydrophilic polymer, to provide a gel. Suitable zinc salts include water-soluble organic salts having relatively low molecular weights (including zinc acetate, butyrate, gluconate, glycerate, glycolate, lactate, propionate, etc.). Highly ionizing inorganic salts, such as zinc chloride or sulfate, can also be used in some formulations. Several preferred salts were tested by human volunteers, during intercourse, and did not cause any detectable irritation.

Abstract translation: 本发明涉及在生殖润滑剂（如避孕套润滑剂或独立凝胶）中使用水溶性锌盐作为抗病毒剂，以降低性传播病毒感染的风险。 这种含锌的抗病毒润滑剂可以在性交前在阴茎的轴上或阴道内扩散，或以其他合适的方式施用，使得在性交期间将润滑剂液体涂覆在一个或多个生殖器表面上。 这些润滑剂也可以密封在含有润滑的避孕套的防水包装中，或作为“独立”润滑剂包装并作为不含安全套的防水容器中销售。 优选的润滑剂含有水溶性润滑剂，例如甘油或聚乙二醇，以及合适的锌盐和水，以促进盐的离子化和锌离子（Zn ++）的释放。 这种润滑剂还可以含有增稠剂或悬浮剂，例如纤维素衍生物，天然胶体化合物或亲水性聚合物，以提供凝胶。 合适的锌盐包括具有相对较低分子量的水溶性有机盐（包括乙酸锌，丁酸盐，葡萄糖酸盐，甘油酸盐，乙醇酸盐，乳酸盐，丙酸盐等）。 高度离子化的无机盐，如氯化锌或硫酸盐，也可用于某些配方中。 人类志愿者在性交期间测试了几种优选的盐，并且没有引起任何可检测的刺激。

公开(公告)号：US5624675A

公开(公告)日：1997-04-29

申请号：US150870

申请日：1993-11-12

Applicant: Patrick D. Kelly

Inventor： Patrick D. Kelly

IPC: A61K31/315 ,  A61K33/30 ,  A01M25/04

CPC classification number: A61K33/30 ,  A61K31/315 ,  Y10S514/934

Abstract: A method is disclosed for using a topical genital lubricant with a non-toxic, non-irritating zinc salt during sexual intercourse. The lubricant is spread upon one or more genital surfaces to create an anti-viral chemical barrier that reduces the risk of infection by the human immunodeficiency virus (HIV), the virus that causes AIDS. Suitable zinc salts include zinc acetate, zinc propionate, and other non-irritating water-soluble organic zinc salts that dissociate readily. When dissolved in water, these salts release divalent zinc ions (Zn.sup.++), which apparently can reduce HIV infectivity by at least three mechanisms. First, zinc ions form crosslinking bonds with cysteine and histidine residues in proteins (such as the gp120 protein of HIV), thereby "gluing" HIV particles to each other, to proteins in vaginal fluids, and to dead or dying cells that will soon be sloughed off from the genital surfaces. This reduces the ability of the HIV to infect susceptible cells. Second, zinc is the active agent in diaper rash ointments and calamine lotion, and it promotes healing and closure of lesions, microabrasions, and other skin breaches; this reduces the ability of HIV to penetrate the skin and reach lymphocytes. Third, concentrations of zinc that do not harm skin can kill HIV-infected lymphocytes, thereby preventing the lymphocytes from infecting other cells via cell--cell binding mechanisms. The toxicity of zinc to lymphocytes also explains why the anti-HIV activity of zinc was not recognized previously, in standard lymphocyte assays.

Abstract translation: 公开了一种在性交期间使用无毒，无刺激性锌盐的局部生殖润滑剂的方法。 润滑剂在一个或多个生殖器表面上扩散以产生抗病毒化学屏障，其降低引起AIDS的病毒的人类免疫缺陷病毒（HIV）的感染风险。 合适的锌盐包括乙酸锌，丙酸锌和容易离解的其它无刺激性的水溶性有机锌盐。 当溶解在水中时，这些盐释放二价锌离子（Zn ++），这显然可以通过至少三种机制降低HIV感染性。 首先，锌离子与蛋白质中的半胱氨酸和组氨酸残基形成交联键（如HIV的gp120蛋白），从而将HIV颗粒彼此粘合到阴道液中的蛋白质，以及即将发生的死亡或死亡细胞 从生殖器表面脱落。 这降低了HIV感染敏感细胞的能力。 第二，锌是尿布疹软膏和钙胺洗剂中的活性剂，它促进病变，微囊和其他皮肤破裂的愈合和闭合; 这降低了HIV穿透皮肤并达到淋巴细胞的能力。 第三，不伤害皮肤的锌的浓度可以杀死HIV感染的淋巴细胞，从而防止淋巴细胞通过细胞 - 细胞结合机制感染其他细胞。 锌对淋巴细胞的毒性也解释了为什么以前在标准淋巴细胞检测中锌的抗HIV活性无法确认。