公开(公告)号：US11933746B2

公开(公告)日：2024-03-19

申请号：US17781098

申请日：2020-11-16

Applicant: Paul Scherrer Institut

Inventor： Soichiro Tsujino ,  Takashi Tomizaki ,  Michal Kepa

IPC: G01N23/20 ,  G01N23/20016 ,  G01N23/20025 ,  G01N23/205

CPC classification number: G01N23/20025 ,  G01N23/20016 ,  G01N23/205 ,  G01N2223/0561 ,  G01N2223/307 ,  G01N2223/309 ,  G01N2223/321 ,  G01N2223/3306 ,  G01N2223/40 ,  G01N2223/501 ,  G01N2223/602

Abstract: A device to host a crystallization medium, such as a solution, for crystal growth and a system for X-ray diffraction experiments to determine the atomic structure of crystals. A plurality of cells have a well, a sample holder placed in the well. The solution is hosted in the sample holder between thin-plates or one thin-plate. A cap seals an opening to the cell and each sample holder can be extracted independently from each well. A system for automated X-ray diffraction experiments for small crystals in the sample holder extracted from the wells utilizes an ultrasonic acoustic levitator to determine the crystal structure at atomic resolution. X-ray diffraction images are generated by scanning the X-ray beam over the levitated sample holder along a spiral trajectory by rotating the sample holder and moving in the direction perpendicular to the X-ray beam and the rotation axis at the same time.

公开(公告)号：US20220404296A1

公开(公告)日：2022-12-22

申请号：US17781098

申请日：2020-11-16

Applicant: Paul Scherrer Institut

Inventor： Soichiro Tsujino ,  Takashi Tomizaki

IPC: G01N23/20025 ,  G01N23/20016 ,  G01N23/205

Abstract: A device to host a crystallization medium, such as a solution, for crystal growth and a system for X-ray diffraction experiments to determine the atomic structure of crystals. A plurality of cells have a well, a sample holder placed in the well. The solution is hosted in the sample holder between thin-plates or one thin-plate. A cap seals an opening to the cell and each sample holder can be extracted independently from each well. A system for automated X-ray diffraction experiments for small crystals in the sample holder extracted from the wells utilizes an ultrasonic acoustic levitator to determine the crystal structure at atomic resolution. X-ray diffraction images are generated by scanning the X-ray beam over the levitated sample holder along a spiral trajectory by rotating the sample holder and moving in the direction perpendicular to the X-ray beam and the rotation axis at the same time.

公开(公告)号：US10753888B2

公开(公告)日：2020-08-25

申请号：US15778722

申请日：2016-10-28

Applicant: PAUL SCHERRER INSTITUT

Inventor： Takashi Tomizaki ,  Soichiro Tsujino

IPC: G01N23/20025 ,  G10K15/00 ,  B01L3/02 ,  B01L3/06 ,  G01N23/207

Abstract: A method and a system for resolving a crystal structure of a crystal at atomic resolution by collecting X-ray diffraction images. The method includes the steps: a) ejecting a droplet of fluid comprising single or multiple of crystal into an ultrasonic acoustic levitator; b) levitating the droplet of fluid with the crystal in the ultrasonic acoustic levitator; b) monitoring the position and the spinning of the droplet with a visualization apparatus; c) applying X-ray to the crystal, the X-ray stemming from an X-ray source; and d) detecting the X-ray diffraction images from the crystal irradiated by the X-ray source by an X-ray detector being capable to capture two dimensional diffraction patterns.