公开(公告)号：US20140178512A1

公开(公告)日：2014-06-26

申请号：US14000480

申请日：2012-02-17

Applicant: Kevin Kiehm ,  Bernhard Hauptmeier ,  Peter Boderke

Inventor： Kevin Kiehm ,  Bernhard Hauptmeier ,  Peter Boderke

IPC: A61L27/20

CPC classification number: A61L27/20 ,  A61L31/042 ,  C08L5/06 ,  C08L5/00

Abstract: The present invention pertains to a method for the in situ preparation of a filler, comprising the step of applying a polyanionic biopolymer solution at an application site below the dermis of a patient for restoring volume at said application site, wherein the polyanionic biopolymer is selected from pectin and gellan. Furthermore, the present invention pertains to a kit comprising (i) a polyanionic biopolymer solution; and (ii) a solution comprising at least one divalent cation.

Abstract translation: 本发明涉及一种原位制备填料的方法，其包括以下步骤：将聚阴离子生物聚合物溶液施用于患者真皮下方的应用部位，以恢复所述施用部位的体积，其中所述聚阴离子生物聚合物选自 果胶和结冷胶。 此外，本发明涉及一种试剂盒，其包含（i）聚阴离子生物聚合物溶液; 和（ii）包含至少一种二价阳离子的溶液。

公开(公告)号：US08394857B2

公开(公告)日：2013-03-12

申请号：US12653865

申请日：2009-12-18

Applicant: Peter Boderke ,  Alexander Gebauer ,  Bhushan Hardas ,  Bernhard Hauptmeier ,  Rainer Pooth

Inventor： Peter Boderke ,  Alexander Gebauer ,  Bhushan Hardas ,  Bernhard Hauptmeier ,  Rainer Pooth

IPC: A61K31/13

CPC classification number: A61K31/13 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/2054 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention relates to the treatment of an individual afflicted with inflammatory skin diseases comprising administering to the individual an effective amount of a 1-amino-alkylcyclohexane derivative.

Abstract translation: 本发明涉及治疗患有炎性皮肤疾病的个体，包括给予个体有效量的1-氨基 - 烷基环己烷衍生物。

公开(公告)号：US06960561B2

公开(公告)日：2005-11-01

申请号：US10102862

申请日：2002-03-22

Applicant: Peter Boderke

Inventor： Peter Boderke

IPC: A61K9/00 ,  A61K38/28 ,  A61K47/00 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/18 ,  A61K47/24 ,  A61K47/26 ,  A61K47/28 ,  A61K47/36 ,  A61P3/08 ,  A61P3/10 ,  A61K31/20 ,  A61K31/202

CPC classification number: A61K47/18 ,  A61K9/0019 ,  A61K38/28 ,  A61K47/10 ,  A61K47/26

Abstract: The invention relates to a formulation comprising a polypeptide selected from at least one of insulin, an insulin metabolite, an insulin analog, and an insulin derivative; at least one surfactant; optionally at least one preservative; and optionally at least one of an isotonicizing agent, a buffer or an excipient, wherein the formulation is free from or low in zinc. The invention also relates to the production of such insulin preparations and their use as pharmaceutical formulations.

Abstract translation: 本发明涉及包含选自胰岛素，胰岛素代谢物，胰岛素类似物和胰岛素衍生物中的至少一种的多肽的制剂; 至少一种表面活性剂; 任选地至少一种防腐剂; 和任选的至少一种等渗剂，缓冲剂或赋形剂，其中所述制剂不含锌或低锌。 本发明还涉及这种胰岛素制剂的生产及其作为药物制剂的用途。

公开(公告)号：US20050187142A1

公开(公告)日：2005-08-25

申请号：US11007154

申请日：2004-12-09

Applicant: Peter Boderke

Inventor： Peter Boderke

IPC: A61K9/00 ,  A61K38/28 ,  A61K47/00 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/18 ,  A61K47/24 ,  A61K47/26 ,  A61K47/28 ,  A61K47/36 ,  A61P3/08 ,  A61P3/10

CPC classification number: A61K47/18 ,  A61K9/0019 ,  A61K38/28 ,  A61K47/10 ,  A61K47/26

Abstract: The invention relates to a formulation comprising a polypeptide selected from at least one of insulin, an insulin metabolite, an insulin analog, and an insulin derivative; at least one surfactant; optionally at least one preservative; and optionally at least one of an isotonicizing agent, a buffer or an excipient, wherein the formulation is free from or low in zinc. The invention also relates to the production of such insulin preparations and their use as pharmaceutical formulations.

公开(公告)号：US20130143869A1

公开(公告)日：2013-06-06

申请号：US13810337

申请日：2011-07-14

Applicant: Kevin Kiehm ,  Bernhard Hauptmeier ,  Harry Abts ,  Peter Boderke

Inventor： Kevin Kiehm ,  Bernhard Hauptmeier ,  Harry Abts ,  Peter Boderke

IPC: A61K31/55 ,  A61K31/135 ,  A61K31/164 ,  A61K31/4706 ,  A61K31/343

CPC classification number: A61K31/55 ,  A61K8/42 ,  A61K8/49 ,  A61K8/4926 ,  A61K8/63 ,  A61K8/69 ,  A61K31/135 ,  A61K31/137 ,  A61K31/138 ,  A61K31/164 ,  A61K31/335 ,  A61K31/343 ,  A61K31/357 ,  A61K31/435 ,  A61K31/4406 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/4706 ,  A61K31/5415 ,  A61K31/551 ,  A61K31/5513 ,  A61K31/609 ,  A61K45/06 ,  A61K2800/91 ,  A61Q19/06

Abstract: Use of a cationic amphiphilic drug for the preparation of a formulation for the reduction and/or prevention of subcutaneous adipose tissue with improved effectiveness and better reproducible activity.

Abstract translation: 使用阳离子两亲药物制备用于减少和/或预防皮下脂肪组织的制剂，具有改善的有效性和更好的可再生活性。

公开(公告)号：US20130090306A1

公开(公告)日：2013-04-11

申请号：US13639004

申请日：2011-04-07

Applicant: Kevin Kiehm ,  Bernhard Hauptmeier ,  Peter Boderke

Inventor： Kevin Kiehm ,  Bernhard Hauptmeier ,  Peter Boderke

IPC: A61L27/20

CPC classification number: A61K8/0204 ,  A61K8/025 ,  A61K8/365 ,  A61K8/735 ,  A61K8/736 ,  A61K9/1652 ,  A61K31/167 ,  A61K2800/30 ,  A61K2800/54 ,  A61K2800/56 ,  A61K2800/654 ,  A61K2800/72 ,  A61L27/20 ,  A61L31/042 ,  A61Q19/08 ,  Y10T428/2982 ,  C08L5/08

Abstract: The present invention pertains to chitosan beads consisting of chitosan cross-linked with citrate ions. The present invention furthermore pertains to a filler comprising such chitosan-citrate beads. In one embodiment of the instant invention the filler is a dermal filler. In one further embodiment of the present invention the dermal filler is for the treatment of wrinkles and/or folds. In another embodiment of the instant invention the filler is for use in the treatment of a medical condition. The filler provided in the present invention may further comprise one or more active pharmaceutical ingredients. Further, the present invention pertains to a process for preparing the filler as claimed herein.

Abstract translation: 本发明涉及由与柠檬酸根离子交联的壳聚糖组成的壳聚糖珠粒。 本发明还涉及包含这种壳聚糖 - 柠檬酸盐珠粒的填料。 在本发明的一个实施方案中，填料是真皮填料。 在本发明的另一个实施方案中，真皮填料用于治疗皱纹和/或折痕。 在本发明的另一个实施方案中，所述填料用于治疗疾病。 本发明中提供的填料还可以包含一种或多种活性药物成分。 此外，本发明涉及制备本文所要求的填料的方法。

公开(公告)号：US20090275545A1

公开(公告)日：2009-11-05

申请号：US12459952

申请日：2009-07-10

Applicant: Peter Boderke ,  Rainer Pooth ,  Juergen Sandow ,  Matthias Gossel ,  Karl-Heinz Nietsch ,  Gerhard Sattler ,  Gerhard Vogel

Inventor： Peter Boderke ,  Rainer Pooth ,  Juergen Sandow ,  Matthias Gossel ,  Karl-Heinz Nietsch ,  Gerhard Sattler ,  Gerhard Vogel

IPC: A61K31/575 ,  A61P43/00

CPC classification number: A61K9/0019 ,  A61K9/127 ,  A61K31/409 ,  A61K31/685 ,  A61K45/06 ,  A61K47/28 ,  A61K2300/00

Abstract: Aqueous phospholipid systems comprising at least one phospholipid, at least one bile acid and water are suitable for producing medicaments for the treatment of adipose tissue disorders and lead to regression of the pathologically proliferated adipose tissue.

Abstract translation: 包含至少一种磷脂，至少一种胆汁酸和水的磷脂体系适用于制备用于治疗脂肪组织病症的药物并导致病理性增殖的脂肪组织消退。

公开(公告)号：US20070155653A1

公开(公告)日：2007-07-05

申请号：US11683747

申请日：2007-03-08

Applicant: Peter Boderke

Inventor： Peter Boderke

IPC: A61K38/28

CPC classification number: A61K47/18 ,  A61K9/0019 ,  A61K38/28 ,  A61K47/10 ,  A61K47/26

Abstract: The invention relates to a formulation comprising a polypeptide selected from at least one of insulin, an insulin metabolite, an insulin analog, and an insulin derivative; at least one surfactant; optionally at least one preservative; and optionally at least one of an isotonicizing agent, a buffer or an excipient, wherein the formulation is free from or low in zinc. The invention also relates to the production of such insulin preparations and their use as pharmaceutical formulations.

Abstract translation: 本发明涉及包含选自胰岛素，胰岛素代谢物，胰岛素类似物和胰岛素衍生物中的至少一种的多肽的制剂; 至少一种表面活性剂; 任选地至少一种防腐剂; 和任选的至少一种等渗剂，缓冲剂或赋形剂，其中所述制剂不含锌或低锌。 本发明还涉及这种胰岛素制剂的生产及其作为药物制剂的用途。

公开(公告)号：US07205276B2

公开(公告)日：2007-04-17

申请号：US11007154

申请日：2004-12-09

Applicant: Peter Boderke

Inventor： Peter Boderke

IPC: A61K38/28 ,  A61K38/00

CPC classification number: A61K47/18 ,  A61K9/0019 ,  A61K38/28 ,  A61K47/10 ,  A61K47/26

Abstract: The invention relates to a formulation comprising a polypeptide selected from at least one of insulin, an insulin metabolite, an insulin analog, and an insulin derivative; at least one surfactant; optionally at least one preservative; and optionally at least one of an isotonicizing agent, a buffer or an excipient, wherein the formulation is free from or low in zinc. The invention also relates to the production of such insulin preparations and their use as pharmaceutical formulations.

公开(公告)号：US20050187143A1

公开(公告)日：2005-08-25

申请号：US11007155

申请日：2004-12-09

Applicant: Peter Boderke

Inventor： Peter Boderke

IPC: A61K9/00 ,  A61K38/28 ,  A61K47/00 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/18 ,  A61K47/24 ,  A61K47/26 ,  A61K47/28 ,  A61K47/36 ,  A61P3/08 ,  A61P3/10

CPC classification number: A61K47/18 ,  A61K9/0019 ,  A61K38/28 ,  A61K47/10 ,  A61K47/26

Abstract: The invention relates to a formulation comprising a polypeptide selected from at least one of insulin, an insulin metabolite, an insulin analog, and an insulin derivative; at least one surfactant; optionally at least one preservative; and optionally at least one of an isotonicizing agent, a buffer or an excipient, wherein the formulation is free from or low in zinc. The invention also relates to the production of such insulin preparations and their use as pharmaceutical formulations.