公开(公告)号：US20140088081A1

公开(公告)日：2014-03-27

申请号：US14091404

申请日：2013-11-27

Applicant: Pfizer Inc.

Inventor： Michelle Marie Claffey ,  Christopher John Helal ,  Patrick Robert Verhoest

IPC: C07D487/04 ,  A61K31/444 ,  A61K31/473 ,  A61K31/55 ,  A61K31/13 ,  A61K31/27 ,  A61K31/519 ,  A61K31/445

CPC classification number: C07D487/04 ,  A61K31/13 ,  A61K31/27 ,  A61K31/444 ,  A61K31/445 ,  A61K31/473 ,  A61K31/519 ,  A61K31/55

Abstract: The invention provides PDE9-inhibiting compounds of Formula (I), and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, A, and n are as defined herein. Pharmaceutical compositions containing the compounds of Formula I, and uses thereof in treating neurodegenerative and cognitive disorders, such as Alzheimer's disease and schizophrenia, are also provided.

Abstract translation: 本发明提供抑制PDE9的式（I）化合物及其药学上可接受的盐，其中R 1，R 2，R 3，A和n如本文所定义。 还提供了含有式I化合物的药物组合物及其用于治疗神经变性和认知障碍如阿尔茨海默病和精神分裂症的用途。