公开(公告)号：US20230041456A1

公开(公告)日：2023-02-09

申请号：US17843616

申请日：2022-06-17

Applicant: Pfizer Inc.

Inventor： Surabhi SRIVATSA SRINIVASAN ,  Niranjana NAGARAJAN ,  Siler PANOWSKI ,  Yoon PARK ,  Tao SAI ,  Barbra SASU ,  Thomas VAN BLARCOM ,  Mathilde DUSSEAUX ,  Roman GALETTO

IPC: C07K16/28 ,  A61K39/00 ,  C07K14/725 ,  A61P35/02 ,  A61P35/04

Abstract: The disclosure provides CARs (CARs) that specifically bind to CD70. The disclosure further relates to engineered immune cells comprising such CARs, CAR-encoding nucleic acids, and methods of making such CARs, engineered immune cells, and nucleic acids. The disclosure further relates to therapeutic methods for use of these CARs and engineered immune cells comprising these CARs for the treatment of a condition associated with malignant cells expressing CD70 (e.g., cancer).

公开(公告)号：US20250011446A1

公开(公告)日：2025-01-09

申请号：US18639749

申请日：2024-04-18

Applicant: Pfizer Inc.

Inventor： Siler PANOWSKI ,  Tao SAI ,  Barbra Johnson SASU ,  Surabhi SRIVATSA SRINIVASAN ,  Thomas John VAN BLARCOM

IPC: C07K16/28 ,  A61K39/00 ,  A61P35/00

Abstract: The present invention provides antibodies that specifically bind to CD70 (Cluster of Differentiation 70). The invention further provides bispecific antibodies that bind to CD70 and another antigen (e.g., CD3). The invention further relates to antibody encoding nucleic acids, and methods of obtaining such antibodies (monospecific and bispecific). The invention further relates to therapeutic methods for use of these antibodies for the treatment of CD70-mediated pathologies, including cancer.