公开(公告)号：US20230357211A1

公开(公告)日：2023-11-09

申请号：US18245039

申请日：2021-09-13

Applicant: Pfizer Inc.

Inventor： Wesley Dewitt CLARK ,  Judith Gail DEAL ,  Brian Matthew SAMAS

IPC: C07D405/14

CPC classification number: C07D405/14 ,  C07B2200/13

Abstract: This invention relates to crystalline and amorphous forms of 1,5-anhydro-3-({5-chloro-4-[4-fluoro-2-(2-hydroxypropan-2-yl)-1-(propan-2-yl)-1H-benzimidazol-6-yl]pyrimidin-2-yl}amino)-2,3-dideoxy-D-threo-pentitol, to pharmaceutical compositions comprising such solid forms, and to use of such solid forms and pharmaceutical compositions for the treatment of cancer.

公开(公告)号：US20230120188A1

公开(公告)日：2023-04-20

申请号：US18060864

申请日：2022-12-01

Applicant: Pfizer Inc.

Inventor： Shelley ALLEN ,  Patrick Michael DOERNER BARBOUR ,  James Francis BLAKE ,  Sydney Taylor BLANCHE ,  Mark Laurence BOYS ,  Wesley Dewitt CLARK ,  Connor James COWDREY ,  Joshua Ryan DAHLKE ,  Alex Andrew KELLUM ,  Ellen Margaret KNAPP ,  David Austin MORENO ,  Jacob Matthew O'LEARY ,  Li REN ,  Faith Elizabeth WITKOS

IPC: C07D471/04 ,  A61P35/00 ,  A61K31/4375 ,  A61K45/06

Abstract: The invention relates to a compound of Formula I or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and R4 are as defined herein. The invention further relates to pharmaceutical compositions comprising such compounds and salts, and to methods and uses of such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject in need thereof. The invention further relates to solid forms of 8-((2-fluoro-4-(methylthio)phenyl)amino)-2-(2-hydroxyethoxy)-7-methyl-3,4-dihydro-2,7-naphthyridine-1,6(2H,7H)-dione.

公开(公告)号：US20220324861A1

公开(公告)日：2022-10-13

申请号：US17708072

申请日：2022-03-30

Applicant: Pfizer Inc.

Inventor： Shelley ALLEN ,  Patrick Michael DOERNER BARBOUR ,  James Francis BLAKE ,  Sydney Taylor BLANCHE ,  Mark Laurence BOYS ,  Wesley Dewitt CLARK ,  Connor James COWDREY ,  Joshua Ryan DAHLKE ,  Alex Andrew KELLUM ,  Ellen Margaret KNAPP ,  David Austin MORENO ,  Jacob Matthew O'LEARY ,  Li REN ,  Faith Elizabeth WITKOS

IPC: C07D471/04 ,  A61K45/06 ,  A61K31/4375 ,  A61P35/00

Abstract: The invention relates to a compound of Formula I or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and R4 are as defined herein. The invention further relates to pharmaceutical compositions comprising such compounds and salts, and to methods and uses of such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject in need thereof. The invention further relates to solid forms of 8-((2-fluoro-4-(methylthio)phenyl)amino)-2-(2-hydroxyethoxy)-7-methyl-3,4-dihydro-2,7-naphthyridine-1,6(2H,7H)-dione.

公开(公告)号：US20240002384A1

公开(公告)日：2024-01-04

申请号：US18469132

申请日：2023-09-18

Applicant: Pfizer Inc.

Inventor： Shelley ALLEN ,  Patrick Michael DOERNER BARBOUR ,  James Francis BLAKE ,  Sydney Taylor BLANCHE ,  Mark Laurence BOYS ,  Wesley Dewitt CLARK ,  Connor James COWDREY ,  Joshua Ryan DAHLKE ,  Alex Andrew KELLUM ,  Ellen Margaret KNAPP ,  David Austin MORENO ,  Jacob Matthew O'LEARY ,  Li REN ,  Faith Elizabeth WITKOS ,  Jennifer Lynn FULTON

IPC: C07D471/04 ,  A61P35/00 ,  A61K31/4375 ,  A61K45/06

CPC classification number: C07D471/04 ,  A61P35/00 ,  A61K31/4375 ,  A61K45/06

Abstract: The invention relates to a method of treating a MEK-associated tumor by administering to a subject in need thereof a therapeutically effective amount of a solid form 8-((2-fluoro-4-(methylthio)phenyl)amino)-2-(2-hydroxyethoxy)-7-methyl-3,4-dihydro-2,7-naphthyridine-1,6(2H,7H)-dione.