公开(公告)号：US07915300B2

公开(公告)日：2011-03-29

申请号：US10584930

申请日：2005-01-06

Applicant: Magnus Nilsson ,  Xiao-Xiong Zhou ,  Lourdes Oden ,  Bjorn Classon ,  Rolf Noren ,  Urszula Grabowska ,  Philip Jackson ,  Philip Fallon ,  Andrew Carr ,  Mark Liley ,  Matt Tozer ,  Tony Johnson ,  Victor Diaz ,  Laia Crespo ,  Jussi Kangasmetsa ,  Thierry Bonnaud

Inventor： Magnus Nilsson ,  Xiao-Xiong Zhou ,  Lourdes Oden ,  Bjorn Classon ,  Rolf Noren ,  Urszula Grabowska ,  Philip Jackson ,  Philip Fallon ,  Andrew Carr ,  Mark Liley ,  Matt Tozer ,  Tony Johnson ,  Victor Diaz ,  Laia Crespo ,  Jussi Kangasmetsa ,  Thierry Bonnaud

IPC: A61K31/407 ,  A61K31/34 ,  C07D487/04 ,  C07D307/00

CPC classification number: C07D491/04 ,  A61K31/407

Abstract: A compound of the formula II wherein one of R1 and R2 is halo and the other is H or halo; R3 is C1-C4 straight or branched chain, optionally fluorinated, alkyl; R4 is H; or R3 together with R4 and the adjoining backbone carbon defines: a spiro-C5-C7 cycloalkyl, optionally substituted with 1 to 3 substituents selected from halo, hydroxyl, C1-C4 alkyl or C1-C4 haloalkyl; or optionally bridged with a methylene group; or a C4-C6 saturated heterocycle having a hetero atom selected from O, NRa, S, S(═O)2; where Ra is H, C1-C4 alkyl or CH3C(═O); R5 is independently selected from H or methyl; E is —C(═O)—, —S(═O)m—, —NR5S(═O)m—, —NR5C(═O)—, —OC(═O)—, R6 is a stable, optionally substituted, monocyclic or bicyclic, carbocycle or heterocycle; m is independently 0,1 or 2; are inhibitors of cathepsin K and useful in the treatment or prophylaxis of osteoporosis.

Abstract translation: 式II的化合物，其中R 1和R 2中的一个是卤素，另一个是H或卤素; R3是C1-C4直链或支链，任选氟化的烷基; R4是H; 或R 3与R 4一起，相邻的主链碳定义：任选被1至3个选自卤素，羟基，C 1 -C 4烷基或C 1 -C 4卤代烷基的取代基取代的螺C5-C7环烷基; 或任选地与亚甲基桥连; 或具有选自O，NR a，S，S（= O）2的杂原子的C 4 -C 6饱和杂环; 其中R a是H，C 1 -C 4烷基或CH 3 C（= O）; R5独立地选自H或甲基; E是-C（= O） - ， - S（= O）m - ， - NR 5 S（= O）m - ， - NR 5 C（= O） - ， - OC（= O） 取代的，单环或双环的碳环或杂环; m独立地为0,1或2; 是组织蛋白酶K的抑制剂，可用于治疗或预防骨质疏松症。

公开(公告)号：US20050144178A1

公开(公告)日：2005-06-30

申请号：US10832808

申请日：2004-04-27

Applicant: David Chrin ,  Philip Jackson ,  Steven Orszag

Inventor： David Chrin ,  Philip Jackson ,  Steven Orszag

IPC: G06F17/30 ,  H04L12/24

CPC classification number: G06F16/10 ,  Y10S707/99953

Abstract: A file system (i) permits storage capacity to be added easily, (ii) can be expanded beyond a given unit, (iii) is easy to administer and manage, (iv) permits data sharing, and (v) is able to perform effectively with very large storage capacity and client loads. State information from a newly added unit is communicated (e.g., automatically and transparently) to central administration and management operations. Configuration and control information from such operations is communicated (e.g., automatically) back down to the newly added units, as well as existing units. In this way, a file system can span both local storage devices (like disk drives) and networked computational devices transparently to clients. Such state and configuration and control information can include globally managed segments as the building blocks of the file system, and a fixed mapping of globally unique file identifiers (e.g., Inode numbers) and/or ranges thereof, to such segments.

Abstract translation: 文件系统（i）允许容易地添加存储容量，（ii）可以扩展到给定单元之外，（iii）易于管理和管理，（iv）允许数据共享，以及（v）能够执行 有效地具有非常大的存储容量和客户端负载。 来自新添加的单元的状态信息被传达（例如，自动和透明地）到中央管理和管理操作。 来自这些操作的配置和控制信息被传送（例如，自动地）回到新添加的单元以及现有单元。 以这种方式，文件系统可以跨越本地存储设备（如磁盘驱动器）和联网计算设备透明地覆盖客户端。 这种状态和配置和控制信息可以包括作为文件​​系统的构建块的全局管理的段，以及全球唯一的文件标识符（例如，Inode号）和/或其范围的固定映射到这些段。

公开(公告)号：US5393418A

公开(公告)日：1995-02-28

申请号：US912713

申请日：1992-07-13

Applicant: Philip Jackson

Inventor： Philip Jackson

IPC: E03B3/36 ,  E02B8/02 ,  E02B9/04 ,  E03B5/00 ,  F04D29/60 ,  B01D35/02

CPC classification number: E02B9/04 ,  E02B8/026 ,  F04D29/605 ,  Y02E10/22

Abstract: A water intake comprises a common frame and assembled thereto and-forming therewith an integral self-contained unit a pump adapted to be immersed and a trash rake and an associated grid on the suction side of the pump and/or a filter on the discharge side of the pump.

Abstract translation: 进水口包括共同的框架并组装在其上并与其形成一体的独立单元，适于被浸入的泵，以及在泵的吸入侧上的垃圾耙和相关栅格和/或排出侧的过滤器 的泵。

公开(公告)号：USD312330S

公开(公告)日：1990-11-20

申请号：US117142

申请日：1987-11-04

Applicant: Philip Jackson

Designer： Philip Jackson

公开(公告)号：US4889629A

公开(公告)日：1989-12-26

申请号：US143528

申请日：1988-01-13

Applicant: Philip Jackson

Inventor： Philip Jackson

IPC: E02B5/08 ,  B01D29/00 ,  B01D33/00 ,  B01D39/10

CPC classification number: B01D39/10 ,  B01D33/327 ,  B01D2201/62

Abstract: A filter panel comprises a plurality of substantially coplanar openings. It incorporates a two-dimensional array of parallel elongate passages. Each passage delimits a respective one of the openings. The array is substantially coplanar with the openings and the passages are substantially perpendicular to the array. Each opening is convergent from an interior profile both from the inlet and outlet side of the panel.

Abstract translation: 过滤器面板包括多个基本上共面的开口。 它包含平行细长通道的二维阵列。 每个通道限定相应的一个开口。 阵列基本上与开口共面，并且通道基本上垂直于阵列。 每个开口从面板的入口侧和出口侧的内部轮廓收敛。

公开(公告)号：US4814076A

公开(公告)日：1989-03-21

申请号：US143634

申请日：1988-01-13

Applicant: Philip Jackson

Inventor： Philip Jackson

IPC: B01D35/02 ,  B01D29/01 ,  B01D33/00 ,  B01D35/16 ,  B01D46/04

CPC classification number: B01D33/15

Abstract: A filter that can be inserted into a pressurized pipe comprises a filter body designed to be connected to each of two consecutive section of the pipe. Inside the filter body is a generally circular filter member which is rotatable about an axis of the filter body, into which it projects cantilever-fashion. A rim on the filter member carries a rack meshing with a drive wheel. A suction unit on the upstream side of the filter member and disposed along a radius of the filter member is connected to a take-off pipe.

Abstract translation: 可以插入加压管道的过滤器包括设计成连接到管道的两个连续部分中的每一个的过滤器主体。 过滤器本体内部是大致圆形的过滤器构件，其可以围绕过滤体的轴线旋转，其中悬臂方式突出。 过滤器构件上的边缘带有与驱动轮啮合的齿条。 在过滤构件的上游侧并沿着过滤构件的半径设置的抽吸单元连接到排出管。

公开(公告)号：US4275928A

公开(公告)日：1981-06-30

申请号：US068760

申请日：1979-08-23

Applicant: Philip Jackson

Inventor： Philip Jackson

IPC: B28D1/18 ,  E01C23/09

CPC classification number: B28D1/181

Abstract: Planing apparatus is disclosed having a rotatable cutting drum comprising a central, rotatable support, a plurality of secondary supports spaced around the central support and in parallel relationship thereto, and a plurality of apertured cutting members mounted on each secondary support and axially spaced apart. The spaces between the cutting members on one of the secondary supports is bridged or almost bridged when viewed in a direction normal to the axis of the drum by the cutting members on one or more of the other secondary supports. The drum is housed for rotation in a base structure having rear wheels and front wheels which can be displaced vertically to adjust the depth to which a surface, e.g. a road surface, is to be planed. The drum and wheels are driven by a motor supported on the base structure. Various different types of cutting members are disclosed.

Abstract translation: 公开了一种具有可旋转切割滚筒的倾斜装置，该切割滚筒包括中心的可旋转的支撑件，围绕中心支撑件间隔开并与其平行的关系的多个辅助支承件，以及安装在每个辅助支承件上并且轴向隔开的多个有孔切割构件。 当其中一个辅助支撑件上的切割构件之间的空间由一个或多个其它辅助支撑件上的切割构件沿垂直于滚筒的轴线的方向观察时桥接或几乎桥接。 滚筒被容纳在具有后轮和前轮的基座结构中，该基座结构可以垂直移动以调节表面的深度，例如， 一条路面，是要刨平的。 鼓和轮由支撑在基座结构上的马达驱动。 公开了各种不同类型的切割构件。

公开(公告)号：US08478492B2

公开(公告)日：2013-07-02

申请号：US10928070

申请日：2004-08-26

Applicant: Arthur James Taylor ,  Mark Nichols ,  Philip Jackson

Inventor： Arthur James Taylor ,  Mark Nichols ,  Philip Jackson

IPC: G05D3/00 ,  G01C21/00 ,  A01B15/00

CPC classification number: E02F9/264 ,  E01C19/002 ,  E01C19/22 ,  E02F3/32 ,  E02F3/3414 ,  E02F3/7609 ,  E02F3/7636 ,  E02F3/842 ,  E02F3/847 ,  E02F9/2045 ,  E02F9/261 ,  E02F9/265 ,  G01C21/20 ,  G01P15/121 ,  G01S19/10 ,  G05D2201/0202 ,  G06F17/00

Abstract: Embodiments of the present invention are directed to a method and system for performing non-contact based determination of the position of an implement. In one embodiment, a non-contact based measurement system is used to determine the relative position of an implement coupled with a mobile machine. The geographic position of the mobile machine is determined and the geographic position of said implement based upon the geographic position of the mobile machine and the position of the implement relative to the mobile machine.

Abstract translation: 本发明的实施例涉及一种用于执行非接触式确定工具的位置的方法和系统。 在一个实施例中，使用基于非接触的测量系统来确定与移动机器耦合的工具的相对位置。 基于移动机器的地理位置和工具相对于移动机器的位置，确定移动机器的地理位置和所述工具的地理位置。

公开(公告)号：US20110190257A1

公开(公告)日：2011-08-04

申请号：US12999003

申请日：2009-07-01

Applicant: Robert Andrew Heald ,  Philip Jackson ,  Joseph P. Lyssikatos ,  Stephen Price ,  Pascal Pierre Alexandre Savy

Inventor： Robert Andrew Heald ,  Philip Jackson ,  Joseph P. Lyssikatos ,  Stephen Price ,  Pascal Pierre Alexandre Savy

IPC: A61K31/397 ,  C07D471/02 ,  C07D231/56 ,  C07D277/62 ,  C07D275/06 ,  A61K31/437 ,  A61K31/416 ,  A61K31/428 ,  A61P35/00

CPC classification number: C07D231/56 ,  C07D275/04 ,  C07D403/12 ,  C07D405/12 ,  C07D471/04

Abstract: The invention relates to bicyclic heterocycles of formulae I and II with anti-cancer and/or anti-inflammatory activity and more specifically with MEK kinase inhibitory activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth, treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.

Abstract translation: 本发明涉及式I和II的双环杂环，其具有抗癌和/或抗炎活性，更具体地涉及MEK激酶抑制活性。 本发明提供了可用于抑制异常细胞生长，治疗过度增殖性疾病或治疗哺乳动物炎性疾病的组合物和方法。 本发明还涉及将化合物用于体外，原位和体内诊断或治疗哺乳动物细胞或相关病理状况的方法。

公开(公告)号：US06267880B1

公开(公告)日：2001-07-31

申请号：US09502466

申请日：2000-02-11

Applicant: Philip Jackson

Inventor： Philip Jackson

IPC: B01D33056

CPC classification number: B01D33/333 ,  B01D2201/4084

Abstract: A mechanical screen employs at least one filter chamber which includes a chassis in the form of a frame and a filter panel disposed transversely in the opening of the chassis and appropriately attached to it. Clipping elements between the filter panel and the chassis are used to attach the filter panel to the chassis. The filter panel, the uprights of the chassis and its longitudinal members are preferably made from materials inert to corrosion. Applications include chain filters.

Abstract translation: 机械屏幕采用至少一个过滤室，其包括框架形式的底盘和横向设置在底盘的开口中并适当地附接到其上的过滤面板。 过滤面板和底盘之间的夹紧元件用于将过滤面板连接到机箱。 过滤面板，底盘及其纵向构件的立柱优选由对腐蚀惰性的材料制成。 应用包括链式过滤器。