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公开(公告)号：US20180193426A1
公开(公告)日：2018-07-12
申请号：US15808814
申请日：2017-11-09
Applicant: PhysioLogic Devices, Inc.
Inventor： Peter C. Lord , William Van Antwerp
CPC classification number: A61K38/28 , A61K9/0019 , A61M5/14276 , A61M31/002 , A61M2025/0057 , A61M2205/0294 , A61M2205/3344 , A61M2205/368 , A61M2205/7581 , A61M2210/1017
Abstract: Exemplary embodiments of the present invention are directed to stabilized insulin compositions suitable for use in implantable artificial pancreatic devices. In embodiments, purified insulin may be made more stable by introducing an insulin analog that will form a heterodimer with the purified insulin. For example, a quantity of between ½ to 10% of one of A21 desamido insulin or Lispro may be added to a purified insulin preparation, resulting in a more stable insulin. Various other methods and preparations of stable insulins, and various catheters for delivering insulins from an implantable device to a body are also presented.
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公开(公告)号：US20210330751A1
公开(公告)日：2021-10-28
申请号：US17368432
申请日：2021-07-06
Applicant: PhysioLogic Devices, Inc.
Inventor： Peter C. Lord , William Van Antwerp
Abstract: A closed device for introducing preservative-free insulin into the intraperitoneal space is presented. In embodiments, the closed device includes an insulin reservoir configured to store preservative-free insulin, a pump connected to the reservoir, and an antimicrobial inlet filter connected to an inlet of the reservoir or provided in an inlet flow path in fluid communication with the reservoir. The device is configured to be disposed in the intraperitoneal space of a body, and to discharge preservative-free insulin into a peritoneal space of the body. In some embodiments, the device includes a second antimicrobial filter, provided at an outlet of the reservoir. In some embodiments, the device further includes a header in fluid communication with the outlet path, and a third antimicrobial filter, provided in the header.
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