公开(公告)号：US20200319100A1

公开(公告)日：2020-10-08

申请号：US16740026

申请日：2020-01-10

Applicant: Picomole Inc.

Inventor： Gisia BEYDAGHYAN ,  Christopher Quentin PURVES ,  Stephen Douglas GRAHAM ,  Erik Justin SCHEME ,  Angkoon PHINYOMARK

IPC: G01N21/39 ,  G01N33/497 ,  G01N1/40

Abstract: Methods and systems for analyzing a sample and generating a predictive model using cavity ring-down spectroscopy are disclosed. At least part of a sample is loaded in a ring-down cavity. For each of a set of wavelengths, a laser beam is generated and directed into the ring-down cavity. The laser beam entering the ring-down cavity is extinguished. Light intensity decay data for light exiting the ring-down cavity is registered via a light intensity sensor system. A probability is determined from the light intensity decay data for the set of wavelengths that a subject from which the sample was received has a physiological condition or a degree of the physiological condition at least indirectly using a dataset of light intensity decay data for previously analyzed samples for which the presence or the absence of the physiological condition or the degree of the physiological condition have been identified.

公开(公告)号：US20210267484A1

公开(公告)日：2021-09-02

申请号：US17034311

申请日：2020-09-28

Applicant: Picomole Inc.

Inventor： Christopher Quentin PURVES

IPC: A61B5/097

Abstract: Apparatuses and methods for collecting a breath sample are provided. A breath input interface is configured to receive exhaled breath. A conduit system extends from the breath input interface and is configured to receive a breath sample storage device at a first end thereof. A storage device valve is positioned on the conduit system towards the first end thereof. At least one controller is configured to open the storage device valve before the breath sample storage device is connected to the first end of the conduit system to allow breath received via the breath input interface to fill the conduit system between the breath input interface and the storage device valve, and subsequently close the storage device valve prior to connection of the breath sample storage device to the conduit system.

公开(公告)号：US20210148814A1

公开(公告)日：2021-05-20

申请号：US17160791

申请日：2021-01-28

Applicant: Picomole Inc.

Inventor： Christopher Quentin PURVES ,  Perry F. KAIN ,  Denis DUFOUR

IPC: G01N21/39 ,  G01N33/497 ,  G01N1/40 ,  G01J3/42 ,  G01N21/3504 ,  G01N21/552 ,  G01J3/02 ,  G01N21/31 ,  G01J3/10

Abstract: There is provided a resonant cavity system. A first mirror is actuated at a first end of a resonant cavity to move in a direction between a first position relative to a second mirror at a second end of the resonant cavity, at which a cavity length between the first mirror and the second mirror is less than a resonance length for a laser beam, and a second position relative to the second mirror, at which the cavity length is greater than the resonance length. An event is triggered when the cavity length is proximal to the resonance length. The first mirror is continuously actuated to move in the direction between the first position and the second position during the event.

公开(公告)号：US20210356392A1

公开(公告)日：2021-11-18

申请号：US17443873

申请日：2021-07-28

Applicant: Picomole Inc.

Inventor： Gisia BEYDAGHYAN ,  Christopher Quentin PURVES ,  Stephen Douglas GRAHAM ,  Erik Justin SCHEME ,  Angkoon PHINYOMARK

IPC: G01N21/39 ,  G01N33/497 ,  G01N1/40 ,  G01J3/42 ,  G01N21/3504 ,  G01N21/552 ,  G01J3/02 ,  G01N21/31 ,  G01J3/10

Abstract: Methods and systems for analyzing a sample and generating a predictive model using cavity ring-down spectroscopy are disclosed. At least part of a sample is loaded in a ring-down cavity. For each of a set of wavelengths, a laser beam is generated and directed into the ring-down cavity. The laser beam entering the ring-down cavity is extinguished. Light intensity decay data for light exiting the ring-down cavity is registered via a light intensity sensor system. A probability is determined from the light intensity decay data for the set of wavelengths that a subject from which the sample was received has a physiological condition or a degree of the physiological condition at least indirectly using a dataset of light intensity decay data for previously analyzed samples for which the presence or the absence of the physiological condition or the degree of the physiological condition have been identified.

公开(公告)号：US20200319099A1

公开(公告)日：2020-10-08

申请号：US16564662

申请日：2019-09-09

Applicant: Picomole Inc.

Inventor： Christopher Quentin PURVES ,  Perry F. KAIN ,  Denis Dufour

IPC: G01N21/39 ,  G01N21/3504 ,  G01N21/552 ,  G01J3/42

Abstract: There is provided a method of tuning a resonant cavity and a cavity ring-down spectroscopy system using the same. A first mirror is actuated at a first end of a resonant cavity to move in a direction between a first position relative to a second mirror at a second end of the resonant cavity, at which a cavity length between the first mirror and the second mirror is less than a resonance length for a laser beam, and a second position relative to the second mirror, at which the cavity length is greater than the resonance length. An event is triggered when the cavity length is proximal to the resonance length. The first mirror is continuously actuated in the direction between the first position and the second position during the event.

公开(公告)号：US20200319093A1

公开(公告)日：2020-10-08

申请号：US16509207

申请日：2019-07-11

Applicant: Picomole Inc.

Inventor： Christopher Quentin PURVES ,  Denis DUFOUR

IPC: G01N21/31 ,  G01J3/42 ,  G01J3/02

Abstract: A cavity ring-down spectroscopy system and a method of modulating a light beam therein are provided. The cavity ring-down spectroscopy system includes at least one laser that generates a light beam, a first optical modulator positioned to attenuate the light beam from the at least one laser, a second optical modulator positioned to attenuate the light beam from the first optical modulator, a ring-down cavity positioned to receive the light beam from the second optical modulator, and at least one light sensor to detect an intensity of light leaked from the ring-down cavity.

公开(公告)号：US20200319028A1

公开(公告)日：2020-10-08

申请号：US16599943

申请日：2019-10-11

Applicant: Picomole Inc.

Inventor： Christopher Quentin PURVES ,  Denis DUFOUR

IPC: G01J3/42 ,  G01J3/10 ,  G01N21/39

Abstract: A spectroscopy system is disclosed, and includes a resonant cavity, a first conduit configured to couple at a first end thereof to a gas source, and at a second end thereof to a first end of a sorbent tube containing a sample for analysis, and a second conduit configured to couple at a first end thereof to a second end of the sorbent tube, and at a second end thereof to the resonant cavity.