公开(公告)号：US20240382957A1

公开(公告)日：2024-11-21

申请号：US18386375

申请日：2023-11-02

Applicant: PLEXBIO CO., LTD.

Inventor： Dean TSAO ,  Fengkan LU ,  Chien Teng KAO

IPC: B01L3/00 ,  B01L7/00 ,  G01N35/00 ,  G01N35/10

Abstract: An automatic sample preparation system is disclosed. The automatic sample preparation system integrates sample pretreatment, extraction, quantitation, and solution preparation into one system. A replacement of manual operations with an automatic system can reduce time and labor costs, reduce human errors, and reduce contamination risk.

公开(公告)号：US20170160272A1

公开(公告)日：2017-06-08

申请号：US15374930

申请日：2016-12-09

Applicant: PLEXBIO CO., LTD.

Inventor： Dean TSAO ,  Chin-Shiou HUANG ,  Yao-Kuang CHUNG

IPC: G01N33/545 ,  G01N33/543 ,  C12Q1/68 ,  G01N33/553

CPC classification number: G01N33/545 ,  C12Q1/6813 ,  C12Q1/6816 ,  C12Q1/6834 ,  G01N33/54326 ,  G01N33/54393 ,  G01N33/553 ,  C12Q2563/149 ,  C12Q2565/501

Abstract: Provided herein are encoded microcarriers for analyte detection in multiplex assays. The microcarriers are encoded with an analog code for identification and include a capture agent for analyte detection. Also provided are methods of making the encoded microcarriers disclosed herein. Further provided are methods and kits for conducting a multiplex assay using the microcarriers described herein.

公开(公告)号：US20190265567A1

公开(公告)日：2019-08-29

申请号：US16386092

申请日：2019-04-16

Applicant: Plexbio Co., Ltd.

Inventor： Dean TSAO ,  Chin-Shiou HUANG ,  Yao-Kuang CHUNG

IPC: G02F1/1362 ,  G09G3/36 ,  H01L27/12

Abstract: Provided herein are encoded microcarriers for analyte detection in multiplex assays. The microcarriers are encoded with an analog code for identification and include a capture agent for analyte detection. Also provided are methods of making the encoded microcarriers disclosed herein. Further provided are methods and kits for conducting a multiplex assay using the microcarriers described herein.

公开(公告)号：US20250027963A1

公开(公告)日：2025-01-23

申请号：US18778582

申请日：2024-07-19

Applicant: PLEXBIO CO., LTD.

Inventor： Dean TSAO ,  Fengkan LU ,  Cheng-Tse LIN

IPC: G01N35/00

Abstract: The present disclosure relates generally to devices and systems for performing automated multiplex assays, and methods of using such devices and systems. In some embodiments, the devices and systems comprise a magnetic module that simplifies and automates processing of encoded microcarriers for molecular and immunoassays.

公开(公告)号：US20240125776A1

公开(公告)日：2024-04-18

申请号：US18516803

申请日：2023-11-21

Applicant: Plexbio Co., Ltd.

Inventor： Dean TSAO ,  Chin-Shiou HUANG ,  Cheng-Tse LIN ,  Chien-Te WU ,  FengKan LU

IPC: G01N33/543 ,  G01N21/64 ,  G01N33/531

CPC classification number: G01N33/54326 ,  G01N21/6458 ,  G01N33/531 ,  G01N33/54346 ,  G01N2446/10

Abstract: Provided herein are encoded microcarriers for analyte detection in multiplex assays. The microcarriers are encoded with an analog code for identification and comprise a capture agent for analyte detection and a substantially transparent magnetic polymer. The analog code is generated by a two-dimensional shape of a substantially non-transparent layer. Also provided are methods of making the encoded microcarriers disclosed herein. Further provided are methods and kits for conducting a multiplex assay using the microcarriers described herein.

公开(公告)号：US20230052147A1

公开(公告)日：2023-02-16

申请号：US17758511

申请日：2021-01-07

Applicant: PLEXBIO CO., LTD.

Inventor： Dean TSAO ,  Chin-Shiou HUANG ,  Shian Pin HU ,  Fei-Yu CHANG ,  Yi Ling HSIEH

IPC: C12Q1/6827 ,  C12Q1/6886 ,  C12Q1/6834

Abstract: Provided herein are methods and kits for detecting the presence of DNA and/or RNA mutations associated with cancer (e.g., lung cancer). The methods and kits employ microcarriers, each with a probe specific for a DNA or RNA mutation and an identifier unique to the probe sequence. Upon isolation and amplification of nucleic acids from a sample, hybridization of amplified DNA with a probe, specific for a DNA or RNA mutation, that is coupled to a microcarrier indicates the presence of the mutation in the sample. Since each microcarrier can be identified through detection of the identifier, multiplex screening assays are provided. Representative genes that can be screened for mutations include, e.g., KRAS, NRAS, PIK3CA, BRAF, EGFR, AKT1, MEK1, and HER2 for DNA mutations and/or ALK, ROS, RET, NTRK1, and cMET for RNA mutations.

公开(公告)号：US20190242884A1

公开(公告)日：2019-08-08

申请号：US16386087

申请日：2019-04-16

Applicant: Plexbio Co., Ltd.

Inventor： Dean TSAO ,  Chin-Shiou HUANG ,  Yao-Kuang CHUNG

IPC: G01N33/545 ,  C12Q1/6813 ,  G01N33/553 ,  G01N33/543 ,  C12Q1/6834 ,  C12Q1/6816

CPC classification number: G01N33/545 ,  C12Q1/6813 ,  C12Q1/6816 ,  C12Q1/6834 ,  G01N33/54326 ,  G01N33/54393 ,  G01N33/553 ,  C12Q2563/149 ,  C12Q2565/501

Abstract: Provided herein are encoded microcarriers for analyte detection in multiplex assays. The microcarriers are encoded with an analog code for identification and include a capture agent for analyte detection. Also provided are methods of making the encoded microcarriers disclosed herein. Further provided are methods and kits for conducting a multiplex assay using the microcarriers described herein.

公开(公告)号：US20140274778A1

公开(公告)日：2014-09-18

申请号：US14208481

申请日：2014-03-13

Applicant: PLEXBIO CO., LTD.

Inventor： Dean TSAO ,  Chin-Shiou HUANG

IPC: G01N33/58

CPC classification number: G01N33/54313 ,  C40B30/04 ,  C40B40/04 ,  C40B50/16

Abstract: Disclosed herein are compositions comprising beads with unique identifiers for storing information about a multiplex assay as well as methods for using the same in multiplex chemical and biological assays.

Abstract translation: 本文公开了包含具有用于存储关于多重测定的信息的唯一标识符的珠的组合物以及在多重化学和生物测定中使用该多核测定的方法。