公开(公告)号：US20240180849A1

公开(公告)日：2024-06-06

申请号：US18285439

申请日：2022-04-12

Applicant: Purdue Research Foundation

Inventor： Yoon Yeo ,  Jianping Wang ,  Fanfei Meng

IPC: A61K9/70 ,  A61K45/06 ,  A61K47/59 ,  A61K49/00 ,  A61P35/00 ,  C12N15/113

CPC classification number: A61K9/70 ,  A61K45/06 ,  A61K47/59 ,  A61K49/0054 ,  A61P35/00 ,  C12N15/1138 ,  A61K2123/00 ,  C12N2310/141

Abstract: The present disclosure generally relates to a composition matter and a method for cancer treatment. In particular, a composition matter as an antitumor immunotherapy comprising a polyethyleneimine derivative as an immunoadjuvant, a chemotherapeutic drug, and optional components such as a microRNA, messenger RNA, plasmid DNA, siRNA, oligonucleotide, or a cyclic dinucleotide. A method for treating a subject with a cancer by administrating a therapeutic effective amount of a composition comprising a polyethyleneimine derivative and an antitumor agent to the subject in need of relief from said cancer is also within the scope of this disclosure.