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公开(公告)号：US10794808B2
公开(公告)日：2020-10-06
申请号：US16072572
申请日：2017-02-03
Applicant: Purdue Research Foundation
Inventor： Katherine Noel Clayton , Tamara Lea Kinzer-Ursem , Steven Truitt Wereley , Janelle Weslyn Salameh
Abstract: Methods and systems suitable for tracking Brownian motion of particles suspended in a fluid and determining the diffusion coefficient of the particles therefrom in order to characterize the particles, their synthesis, and/or their surface modifications. The methods include providing a sample having particles suspended in a fluid, obtaining and recording at least first and second images of the sample wherein the first image obtained at a first time and the second image subsequently obtained at a second time, determining the average displacement of the particles in an area of the first and second images during a time period between the first time and the second time based on the first and second images, and then determining a diffusion coefficient of the particles in the area of the first and second images based on the average displacement of the particles during the time period.
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公开(公告)号：US20190072472A1
公开(公告)日：2019-03-07
申请号：US16072572
申请日：2017-02-03
Applicant: Purdue Research Foundation
Inventor： Katherine Noel Clayton , Tamara Lea Kinzer-Ursem , Steven Truitt Werely , Janelle Weslyn Salameh
IPC: G01N15/02
CPC classification number: G01N15/0227 , G01N2015/0038 , G01N2015/0053 , G01N2015/0238
Abstract: Methods and systems suitable for tracking Brownian motion of particles suspended in a fluid and determining the diffusion coefficient of the particles therefrom in order to characterize the particles, their synthesis, and/or their surface modifications. The methods include providing a sample having particles suspended in a fluid, obtaining and recording at least first and second images of the sample wherein the first image obtained at a first time and the second image subsequently obtained at a second time, determining the average displacement of the particles in an area of the first and second images during a time period between the first time and the second time based on the first and second images, and then determining a diffusion coefficient of the particles in the area of the first and second images based on the average displacement of the particles during the time period.
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公开(公告)号：US11221287B2
公开(公告)日：2022-01-11
申请号：US15846430
申请日：2017-12-19
Applicant: Purdue Research Foundation
Inventor： Steven Truitt Wereley , Tamara Lea Kinzer-Ursem , Katherine Noel Clayton , Jacqueline Callihan Linnes , Donghoon Lee , Taylor Jo Moehling
Abstract: This invention relates to a method for measuring viscosity of a fluid using particle diffusometry (PD). The method finds practical applications in detecting structural and functional changes of a biomolecular composition by comparing the viscosity change as compared with the standard of the biomolecular composition. This method may also find uses in clinical diagnosis and quality control of clinical biological medicines, food and feeds during the process of manufacturing, distribution and consumption.
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公开(公告)号：US20180195944A1
公开(公告)日：2018-07-12
申请号：US15846430
申请日：2017-12-19
Applicant: Purdue Research Foundation
Inventor： Steven Truitt Wereley , Tamara Lea Kinzer-Ursem , Katherine Noel Clayton , Jacqueline Callihan Linnes , Donghoon Lee , Taylor Jo Moehling
CPC classification number: G01N11/10 , G01N11/00 , G01N13/00 , G01N15/1429 , G01N2011/006 , G01N2011/008 , G01N2013/003 , G01N2015/0003 , G01N2015/0053
Abstract: This invention relates to a method for measuring viscosity of a fluid using particle diffusometry (PD). The method finds practical applications in detecting structural and functional changes of a biomolecular composition by comparing the viscosity change as compared with the standard of the biomolecular composition. This method may also find uses in clinical diagnosis and quality control of clinical biological medicines, food and feeds during the process of manufacturing, distribution and consumption.
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