公开(公告)号：US12264119B2

公开(公告)日：2025-04-01

申请号：US18229220

申请日：2023-08-02

Applicant: Qingdao University of Science and Technology

Inventor： Peizhe Cui ,  Jianguang Qi ,  Wenhui Xu ,  Yinglong Wang ,  Zhaoyou Zhu ,  Kaiguang Wang ,  Xin Li ,  Fanqing Meng ,  Limei Zhong ,  Shuli Yin ,  Lei Han ,  Jianbo Jia ,  Zhonghui Zheng

IPC: C07C2/54 ,  B01J8/00 ,  B01J8/08

Abstract: A process and a device for continuous flow side-chain alkylation which relate to the technical field of organic synthesis. In this process and the device for continuous flow side-chain alkylation, an ibuprofen raw material is prepared with alkylbenzene as a raw material. This raw material alkylbenzene is easily available and has a low cost, and is suitable for scale-up production. Moreover, an entire preparation process adopts continuous chemical synthesis, and a reaction time of each stage can be precisely controlled, which is beneficial to control a total reaction time and reduce an amount of impurities produced. In this way, a purity and a yield of the ibuprofen raw material are improved. In summary, a continuous synthesis method for side-chain alkylation of alkylbenzene provided by the present disclosure shows a low cost and a high yield.