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    Method and apparatus for the endoluminal delivery of intravascular devices
    2.
    发明授权
    Method and apparatus for the endoluminal delivery of intravascular devices 有权
    用于血管内装置的腔内递送的方法和装置

    公开(公告)号：US09119738B2

    公开(公告)日：2015-09-01

    申请号：US13171400

    申请日：2011-06-28

    Applicant: R. David Fish

    Inventor： R. David Fish

    IPC: A61F2/958 ,  A61F2/962 ,  A61M25/00 ,  A61M25/01 ,  A61M25/10

    CPC classification number: A61F2/958 ,  A61F2/962 ,  A61M25/0074 ,  A61M2025/0058 ,  A61M2025/0175 ,  A61M2025/1081

    Abstract: A dual-balloon delivery catheter system includes a carrier segment that is a lead/carrier balloon or mandrel at a distal portion of a catheter. The carrier segment is sequentially arrayed with a more proximally positioned delivery segment, wherein the delivery segment is a delivery balloon or mandrel. The first carrier segment expands the stent-valve a sufficient amount to receive the delivery segment after the carrier segment is moved away from the sent-valve. The delivery segment is then positioned at the target site and the stent-valve is then deployed.

    Abstract translation: 双球囊递送导管系统包括作为导管远端部分处的引导/载体球囊或心轴的载体片段。 载体片段依次排列有较近端定位的递送片段，其中递送片段是递送球囊或心轴。 第一载体段在载体段从传递阀移开之后使支架瓣膨胀足够的量以接收输送段。 然后将输送段定位在目标位置，然后展开支架瓣膜。

    Percutaneously deliverable heart valve including folded membrane cusps with integral leaflets
    5.
    发明授权
    Percutaneously deliverable heart valve including folded membrane cusps with integral leaflets 有权

    公开(公告)号：US09737400B2

    公开(公告)日：2017-08-22

    申请号：US13326196

    申请日：2011-12-14

    Applicant: R. David Fish ,  Eduaro Induni ,  David Paniagua

    Inventor： R. David Fish ,  Eduaro Induni ,  David Paniagua

    IPC: A61F2/24

    CPC classification number: A61F2/2415 ,  A61F2/2418 ,  A61F2220/0075 ,  A61F2230/0054

    Abstract: A transcatheter, percutaneously implantable, prosthetic heart valve is provided that comprises a lattice frame and two or more integrated cusp and leaflet folded structures attached to the lattice frame. The two or more integrated cusp and leaflet folded structures each comprise a flat sheet of biocompatible membrane that is folded to include a substantially conical shape according to a flat folding pattern. The substantially conical shape is further formed by joining apposing sides of the substantially conical shape along a seam. The two or more integrated cusp and leaflet folded structures are each attached along their respective seams to the lattice frame in a direction substantially parallel to an axis of the lattice frame. Embodiments of valves described herein have application within the entire vascular system.

    Percutaneously deliverable heart valve and methods associated therewith
    6.
    发明授权
    Percutaneously deliverable heart valve and methods associated therewith 有权
    经皮输送的心脏瓣膜及其相关的方法

    公开(公告)号：US08361144B2

    公开(公告)日：2013-01-29

    申请号：US13038361

    申请日：2011-03-01

    Applicant: R. David Fish ,  David Paniagua

    Inventor： R. David Fish ,  David Paniagua

    IPC: A61F2/24

    CPC classification number: A61F2/2427 ,  A61F2/0095 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2/2418 ,  A61F2/2433 ,  A61F2220/0075 ,  Y10T29/49908 ,  Y10T156/10

    Abstract: A prosthetic heart valve implantable by catheter without surgery includes a substantially “dry” membrane or tissue material. In at least one embodiment, the tissue is folded in a dry state to form a tissue leaflet assembly that is then attached to a frame to form an implantable prosthetic heart valve. Alternatively, one or more tissue leaflets are operatively associated with a frame to form an implantable prosthetic heart valve. The implantable prosthetic heart valve is subsequently pre-mounted on an integrated catheter delivery system. The catheter delivery system that includes the implantable prosthetic heart valve is then packaged and transported while the tissue remains dry. The implantable prosthetic heart valve, while remaining substantially dry, can then be implanted into the receiving patient.

    Abstract translation: 可以通过没有手术的导管植入的假体心脏瓣膜包括基本干燥的膜或组织材料。 在至少一个实施例中，组织以干燥状态折叠以形成组织小叶组件，然后将组织小叶组件附接到框架以形成可植入的假体心脏瓣膜。 或者，一个或多个组织小叶与框架可操作地相关联以形成可植入假体心脏瓣膜。 随后将可植入式假体心脏瓣膜预先安装在集成的导管递送系统上。 包括可植入假体心脏瓣膜的导管递送系统然后在组织保持干燥时被包装和运输。 可植入假体心脏瓣膜虽然保持基本上干燥，然后可以植入接受患者。

    TISSUE FOR PROSTHETIC IMPLANTS AND GRAFTS, AND METHODS ASSOCIATED THEREWITH
    8.
    发明申请
    TISSUE FOR PROSTHETIC IMPLANTS AND GRAFTS, AND METHODS ASSOCIATED THEREWITH 审中-公开
    用于植入植物和植物的组织，以及与之相关的方法

    公开(公告)号：US20110300625A1

    公开(公告)日：2011-12-08

    申请号：US13038260

    申请日：2011-03-01

    Applicant: David PANIAGUA ,  R. David Fish

    Inventor： David PANIAGUA ,  R. David Fish

    IPC: C12N5/071

    CPC classification number: A01N1/0231 ,  A61L27/3625 ,  A61L27/3687 ,  A61L2430/40

    Abstract: A prepared tissue for medical use with a patient is provided. Methods for preparing such tissue are also provided. Implantable tissue is provided by harvesting a tissue, such as but not limited to a pericardium tissue, and exposing the tissue to various cleaning, rinsing, treatment, separating, and fixation steps. The tissue of at least one embodiment is cleaned with distilled water, rinsed with isopropyl alcohol, and treated with a glutaraldehyde solution. The prepared tissue may be allowed to dry or partially hydrated prior to packaging and shipment. As such, the tissue can be implanted into the receiving patient in either a dry or wet state. The relatively thin yet strong tissue material is adapted for implanting within or grafting to human tissue. By way of example, the tissue may be used in a shunt, a valve, as graft material, as a patch, as a prosthetic tissue in a tendon and/or ligament, and a tissue product for wound management.

    Abstract translation: 提供了一种用于医疗用途的患者组织。 还提供了制备这种组织的方法。 通过收集组织（例如但不限于心包组织）并将组织暴露于各种清洁，漂洗，处理，分离和固定步骤来提供可植入组织。 至少一个实施方案的组织用蒸馏水清洗，用异丙醇漂洗，并用戊二醛溶液处理。 在包装和运输之前，准备好的组织可以被干燥或部分水合。 因此，可以在干燥或潮湿状态下将组织植入接受患者。 相对薄而强的组织材料适于植入人体组织或移植到人体组织中。 作为示例，组织可以用作分流器，瓣膜，移植材料，补片，肌腱和/或韧带中的假体组织，以及用于伤口管理的组织产品。

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