公开(公告)号：US20170065323A1

公开(公告)日：2017-03-09

申请号：US15257827

申请日：2016-09-06

Applicant: R2 Dermatology, Inc.

Inventor： Jesse Rosen ,  Kevin Springer ,  Kristine Tatsutani ,  Michael O'Neil

IPC: A61B18/02 ,  A61B18/20

Abstract: Embodiments of the present invention generally relate to methods, devices, and systems for reducing a pigmentation of a skin of a patient. In some embodiments, freezing of the skin may be desirable to effect the hypopigmentation of the skin of the patient. Generally, embodiments may limit supercooling (or promote freezing) of the skin of the patient during a cooling treatment. In some embodiments, coupling fluids are provided to reduce a thermal contact resistance between a cooling treatment probe and the skin of the patient to improve cooling treatment. Optionally, a fluid carrier may be provided to help retain the coupling fluid at the treatment site. In some embodiments, the coupling fluid may include ice nucleating agents to promote ice crystal formation in the coupling fluid during cooling treatment. The ice crystal formation in the coupling fluid may progress into the skin to limit supercooling of the skin during treatment.

Abstract translation: 本发明的实施方案一般涉及用于减少患者皮肤色素沉着的方法，装置和系统。 在一些实施方案中，皮肤的冷冻可能是期望的，以实现患者皮肤色素沉着减少。 通常，实施例可限制在冷却治疗期间患者皮肤的过冷（或促进冷冻）。 在一些实施例中，提供耦合流体以减少冷却治疗探针与患者皮肤之间的热接触电阻，以改善冷却治疗。 可选地，可以提供流体载体以帮助在处理部位保持耦合流体。 在一些实施方案中，耦合流体可以包括冰成核剂，以在冷却处理期间促进耦合流体中的冰晶形成。 耦合流体中的冰晶形成可进入皮肤以限制治疗过程中皮肤的过冷。

公开(公告)号：US20170348143A1

公开(公告)日：2017-12-07

申请号：US15612740

申请日：2017-06-02

Applicant: R2 Dermatology, Inc.

Inventor： Jesse Rosen ,  Kevin Springer ,  Kristine Tatsutani ,  Michael O'Neil ,  Benjamin Sun ,  Erik Stauber

IPC: A61F7/00 ,  A61H23/00

CPC classification number: A61F7/0085 ,  A61F7/007 ,  A61F2007/0052 ,  A61F2007/0063 ,  A61F2007/0075 ,  A61F2007/0086 ,  A61F2007/0087 ,  A61F2007/0093 ,  A61F2007/0096 ,  A61H23/008 ,  A61H23/0236 ,  A61H23/0245 ,  A61H23/0263 ,  A61H2201/0153 ,  A61H2201/0214 ,  A61H2201/0257 ,  A61H2201/0285 ,  A61H2201/5028 ,  A61H2201/5061 ,  A61H2230/505

Abstract: The present invention generally relates to improved medical devices, systems, and methods, with exemplary embodiments providing improved cooling treatment probes and cooling treatment methods and systems. In some embodiments, freezing of the skin may be desirable to effect the hypopigmentation of the skin of the patient. Generally, embodiments may limit supercooling of the skin of the patient during a cooling treatment. Additionally, embodiments may limit adverse side effects such as hyperpigmentation. It has been found that the freezing behavior (frequency and time to freeze) can be modified by adjusting the thermal parameters of the cooling applicator. Accordingly, in some aspects of the invention, a method of treating the skin may be provided where the thermal parameters of the cooling applicator are adjusted during treatment.