公开(公告)号：US20240123087A1

公开(公告)日：2024-04-18

申请号：US18282181

申请日：2022-03-18

Applicant: ReCode Therapeutics, Inc.

Inventor： Daniella Ishimaru ,  Brandon Wustman ,  Mirko Hennig ,  Dave Liston ,  Rumpa Bhattacharjee

IPC: A61K48/00 ,  A61K9/127 ,  A61K9/51 ,  A61P11/00 ,  C07K14/47

CPC classification number: A61K48/005 ,  A61K9/1271 ,  A61K9/5123 ,  A61K9/5146 ,  A61P11/00 ,  C07K14/47

Abstract: Compositions of polynucleotide(s) are disclosed. A polynucleotide may encode for a polypeptide, protein, or functional fragment thereof associated with primary ciliary dyskinesia (PCD). Pharmaceutical compositions, kits, and methods for treating a disease or condition associated with cilia maintenance and function, and impaired function of the axoneme are also disclosed. The polynucleotide may be combined with a lipid composition.