公开(公告)号：US20240285533A1

公开(公告)日：2024-08-29

申请号：US18593245

申请日：2024-03-01

Applicant: ReCode Therapeutics, Inc.

Inventor： Mirko Hennig ,  Ali Ahmed Alfaifi ,  Sakya Sing Mohapatra ,  Daniella Ishimaru ,  Vladimir Grigor'evich Kharitonov ,  Julia Jung-un Baek ,  Shuang Li ,  David J. Lockhart ,  Brandon A. Wustman ,  Yufeng Wang ,  Joseph S. Cefalu

IPC: A61K9/14 ,  A61K9/00 ,  A61K47/24 ,  A61K47/26 ,  A61K47/28 ,  A61K48/00 ,  C07K14/705

CPC classification number: A61K9/145 ,  A61K9/0078 ,  A61K47/24 ,  A61K47/26 ,  A61K47/28 ,  A61K48/0008 ,  C07K14/705

Abstract: Provided are methods for delivering lipid nanoparticles (LNPs) to a lung cell of a subject suffering from or at risk for cystic fibrosis (CF), wherein the method comprises nebulizing a liquid pharmaceutical composition to generate an aerosolized pharmaceutical composition, and administering the aerosolized pharmaceutical composition to the subject, wherein the LNPs comprise mRNA encoding a Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein.

公开(公告)号：US20240216290A1

公开(公告)日：2024-07-04

申请号：US18413653

申请日：2024-01-16

Applicant: Joe Cefalu ,  ReCode Therapeutics, Inc.

Inventor： Mirko Hennig ,  Ali Alfaifi ,  Sakya Sing Mohapatra ,  Daniella Ishimaru ,  Vladimir Kharitonov ,  Jung Un Baek ,  Shuang Li ,  David J. Lockhart ,  Brandon A. Wustman ,  Yufeng Wang ,  Joe Cefalu

IPC: A61K9/51 ,  A61K9/00 ,  A61K48/00

CPC classification number: A61K9/5123 ,  A61K9/0078 ,  A61K48/0033

Abstract: Provided are methods for delivering lipid nanoparticles (LNPs) to a lung cell of a subject suffering from or at risk for primary ciliary dyskinesia (PCD), wherein the method comprises nebulizing a liquid pharmaceutical composition to generate an aerosolized pharmaceutical composition, and administering the aerosolized pharmaceutical composition to the subject.

公开(公告)号：US20250032424A1

公开(公告)日：2025-01-30

申请号：US18886134

申请日：2024-09-16

Applicant: ReCode Therapeutics, Inc.

Inventor： Mirko Hennig ,  Ali Ahmed Alfaifi ,  Sakya Sing Mohapatra ,  Daniella Ishimaru ,  Vladimir Grigor'evich Kharitonov ,  Julia Jung-un Baek ,  Shuang Li ,  David J. Lockhart ,  Brandon A. Wustman ,  Yufeng Wang ,  Joseph S. Cefalu

IPC: A61K9/51 ,  A61K9/00 ,  A61K9/14 ,  A61K47/24 ,  A61K47/26 ,  A61K47/28 ,  A61K48/00 ,  C07K14/705

Abstract: Provided are methods for delivering lipid nanoparticles (LNPs) to a lung cell of a subject suffering from or at risk for primary ciliary dyskinesia (PCD), wherein the method comprises nebulizing a liquid pharmaceutical composition to generate an aerosolized pharmaceutical composition, and administering the aerosolized pharmaceutical composition to the subject.

公开(公告)号：US12133923B2

公开(公告)日：2024-11-05

申请号：US18413653

申请日：2024-01-16

Applicant: ReCode Therapeutics, Inc.

Inventor： Mirko Hennig ,  Ali Ahmed Alfaifi ,  Sakya Sing Mohapatra ,  Daniella Ishimaru ,  Vladimir Grigor'evich Kharitonov ,  Julia Jung-un Baek ,  Shuang Li ,  David J. Lockhart ,  Brandon A. Wustman ,  Yufeng Wang ,  Joseph S. Cefalu

IPC: A61K9/51 ,  A61K8/86 ,  A61K9/00 ,  A61K31/7105 ,  A61K47/14 ,  A61K47/18 ,  A61K47/22 ,  A61K47/24 ,  A61K47/28 ,  A61K48/00 ,  C07C69/708 ,  C07C223/02 ,  C07C321/14 ,  C07D317/32

Abstract: Provided are methods for delivering lipid nanoparticles (LNPs) to a lung cell of a subject suffering from or at risk for primary ciliary dyskinesia (PCD), wherein the method comprises nebulizing a liquid pharmaceutical composition to generate an aerosolized pharmaceutical composition, and administering the aerosolized pharmaceutical composition to the subject.