公开(公告)号：US10179187B2

公开(公告)日：2019-01-15

申请号：US14098443

申请日：2013-12-05

Applicant: Regents of the University of Minnesota

Inventor： Jafar Golzarian ,  Lihui Weng

IPC: A61B19/00 ,  A61L24/08 ,  A61L24/00

Abstract: The present disclosure is generally directed to an embolic material which, in some embodiments, may be in the form of a microsphere or a plurality of microspheres. The embolic material generally comprises carboxymethyl chitosan (CCN) crosslinked with carboxymethyl cellulose (CMC). In some embodiments, the embolic material may further comprise a therapeutic agent, such as doxorubicin.

公开(公告)号：US20170319326A1

公开(公告)日：2017-11-09

申请号：US15585869

申请日：2017-05-03

Applicant: Regents of the University of Minnesota

Inventor： Michael Rosenberg ,  Sean Lester Moen ,  Jafar Golzarian ,  Victor Barocas

IPC: A61F2/07 ,  A61B5/0215

Abstract: A vascular graft includes deformable sleeves that include an electrical component. The electrical component can be variable-resistance or piezoelectric, in embodiments, such that deformation of the sleeves due to pressure changes create or modify an electrical signal. A transponder can then transmit information relating to the pressure inside and outside of the vascular graft.

公开(公告)号：US20160346521A1

公开(公告)日：2016-12-01

申请号：US15161860

申请日：2016-05-23

Applicant: Regents of the University of Minnesota

Inventor： Jafar Golzarian ,  Sean Lester Moen ,  Michael Rosenberg

IPC: A61M25/10 ,  A61B17/12 ,  A61M25/00

CPC classification number: A61B17/12109 ,  A61B17/1204 ,  A61B17/12136 ,  A61B17/12159 ,  A61B17/12186 ,  A61B2017/00818 ,  A61B2017/00893 ,  A61B2017/1205 ,  A61M25/0032 ,  A61M2025/0042

Abstract: A multi-lumen catheter defining a longitudinal axis includes an inflation lumen, a plug lumen, and a microcatheter lumen, each defined by the catheter and extending substantially parallel to the longitudinal axis. The inflation lumen defines an inlet aperture and an outlet aperture and is configured to provide a fluidic connection from the inlet aperture of the inflation lumen to a balloon. The plug lumen defines an inlet aperture and an outlet aperture and is configured to deliver a plug. The microcatheter lumen defines an inlet aperture and an outlet aperture and is configured to house a microcatheter.

Abstract translation: 限定纵向轴线的多腔导管包括充气腔，插管腔和微导管腔，每个腔由导管限定并基本上平行于纵向轴线延伸。 充气腔限定入口孔和出口孔，并且构造成提供从充气腔的入口孔到气囊的流体连接。 塞子管腔限定入口孔和出口孔，并且构造成输送塞子。 微导管腔限定入口孔和出口孔，并且构造成容纳微导管。

公开(公告)号：US20230248441A1

公开(公告)日：2023-08-10

申请号：US18003295

申请日：2021-06-29

Applicant: Regents of the University of Minnesota

Inventor： Enio T. Perez Filho ,  Braden Eliason ,  Reza Talaie ,  Aaron Koenigsberg ,  Jafar Golzarian

IPC: A61B34/20 ,  A61B90/00

CPC classification number: A61B34/20 ,  A61B90/361

Abstract: Techniques are disclosed for extended-reality (XR) visualization of a flexible medical tool. In one example, sensor(s), disposed near a distal portion of a flexible shaft of a medical tool configured for insertion into a patient, sense values indicative of a pose of the medical tool with respect to an EM field. A computing device adjusts, based on the sensed values, a relative alignment between the medical tool, an internal anatomy of the patient, and an exterior of the body of the patient. The computing device generates, based on the computed relative alignment between the medical tool, the internal anatomy, and the exterior of the body, XR content comprising a visual representation of the medical tool within the patients internal anatomy, and outputs the XR content for display to a user so as to simulate a current pose of the medical tool relative to the body of the patient.

公开(公告)号：US20230095373A1

公开(公告)日：2023-03-30

申请号：US17931465

申请日：2022-09-12

Applicant: Regents of the University of Minnesota

Inventor： Jafar Golzarian ,  Lihui Weng

IPC: A61L24/08 ,  A61L24/00

Abstract: The present disclosure is generally directed to an embolic material which, in some embodiments, may be in the form of a microsphere or a plurality of microspheres. The embolic material generally comprises carboxymethyl chitosan (CCN) crosslinked with carboxymethyl cellulose (CMC). In some embodiments, the embolic material may further comprise a therapeutic agent, such as doxorubicin.

公开(公告)号：US20180078661A1

公开(公告)日：2018-03-22

申请号：US15709124

申请日：2017-09-19

Applicant: Regents of the University of Minnesota

Inventor： Lihui Weng ,  Jafar Golzarian

IPC: A61K49/18 ,  A61K31/704

CPC classification number: A61K49/1863 ,  A61K9/0019 ,  A61K9/1652 ,  A61K31/137 ,  A61K31/404 ,  A61K31/4745 ,  A61K31/704 ,  A61K47/38

Abstract: The present disclosure is generally directed to an embolic material which, in some examples, may be in the form of a microsphere or a plurality of microspheres. The embolic material may include carboxymethyl chitosan (CCN) crosslinked with partially oxidized carboxymethyl cellulose (OCMC) and an imaging agent such as at least one of an ethiodized oil, a radiopaque metal, or super paramagnetic iron oxide nanoparticles integrally contained within the microsphere.

公开(公告)号：US20250090719A1

公开(公告)日：2025-03-20

申请号：US18291525

申请日：2022-07-29

Applicant: Regents of the University of Minnesota

Inventor： Jafar Golzarian ,  Chen Guo

IPC: A61L24/10 ,  A61L24/00 ,  A61L24/04

Abstract: A biomaterial includes keratin proteins crosslinked with linking groups chosen from thiosuccinimide, thioether sulfone, and mixtures and combinations thereof.

公开(公告)号：US20170273888A1

公开(公告)日：2017-09-28

申请号：US15466301

申请日：2017-03-22

Applicant: Regents of the University of Minnesota ,  EmboMedics, Inc.

Inventor： Lihui Weng ,  Jafar Golzarian ,  Omid Souresrafil

IPC: A61K8/73 ,  A61Q19/00

CPC classification number: A61K8/736 ,  A61K8/025 ,  A61K8/731 ,  A61K31/745 ,  A61K2800/28 ,  A61Q11/00 ,  A61Q19/00 ,  A61Q19/007 ,  A61Q19/08

Abstract: The present disclosure describes a plurality of microspheres that include carboxymethyl chitosan (CCN) crosslinked with carboxymethyl cellulose (CMC). The microspheres are biocompatible, bioresorbable, and biodegradable. The microspheres may be used in personal care products, such as, for example, toothpaste, topical pain relief products, topical antibiotic products, skincare products such as anti-wrinkle products, eczema products, skin scrubs, acne cleansers, exfoliators, body washes, soaps, pre-shave creams, or the like.

公开(公告)号：US20140171907A1

公开(公告)日：2014-06-19

申请号：US13720135

申请日：2012-12-19

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： Jafar Golzarian ,  Lihui Weng

IPC: A61L24/04 ,  A61M5/178 ,  A61M25/00

CPC classification number: A61L24/043 ,  A61L31/041 ,  A61L31/145 ,  A61L31/16 ,  A61L31/18 ,  A61L2430/36 ,  A61M5/178 ,  A61M5/19 ,  C08L5/08 ,  C08L1/28

Abstract: A liquid embolic material may include a mixture of a first solution comprising between about 1.2% and about 2.5% weight per volume (w/v) carboxymethyl chitosan (CCN) in a first solvent and a second solution comprising between about 1.2% and about 2.5% w/v oxidized carboxymethyl cellulose (OCMC) in a second solvent. The liquid embolic material may be used to embolize a targeted embolization location by mixing the first solution and the second solution to form a liquid embolic material (or hydrogel precursor material), introducing the hydrogel precursor material to a targeted embolization location within a body of a patient, and allowing the CCN and the OCMC to react to form the hydrogel material and embolize the targeted embolization location.

Abstract translation: 液体栓塞材料可以包括在第一溶剂中包含约1.2％至约2.5％重量/体积（w / v）羧甲基壳聚糖（CCN）的第一溶液和包含约1.2％至约2.5％的第二溶液的混合物 ％w / v氧化的羧甲基纤维素（OCMC）在第二溶剂中。 液体栓塞材料可以用于通过混合第一溶液和第二溶液来栓塞目标栓塞位置以形成液体栓塞材料（或水凝胶前体材料），将水凝胶前体材料引入到体内的目标栓塞位置 患者，并允许CCN和OCMC反应形成水凝胶材料并栓塞目标栓塞位置。

公开(公告)号：US20140099374A1

公开(公告)日：2014-04-10

申请号：US14098443

申请日：2013-12-05

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： Jafar Golzarian ,  Lihui Weng

IPC: A61L24/08 ,  A61L24/00

CPC classification number: A61L24/08 ,  A61L24/0015 ,  A61L2300/406 ,  A61L2300/622 ,  A61L2430/36 ,  Y10T428/2982 ,  C08L5/08 ,  C08L1/28

Abstract: The present disclosure is generally directed to an embolic material which, in some embodiments, may be in the form of a microsphere or a plurality of microspheres. The embolic material generally comprises carboxymethyl chitosan (CCN) crosslinked with carboxymethyl cellulose (CMC). In some embodiments, the embolic material may further comprise a therapeutic agent, such as doxorubicin.

Abstract translation: 本公开总体上涉及栓塞材料，其在一些实施方案中可以是微球体或多个微球体的形式。 栓塞材料通常包含与羧甲基纤维素（CMC）交联的羧甲基壳聚糖（CCN）。 在一些实施方案中，栓塞材料还可以包含治疗剂，例如多柔比星。