公开(公告)号：US20170049327A1

公开(公告)日：2017-02-23

申请号：US15243391

申请日：2016-08-22

Applicant: Robert R. Alfano

Inventor： ROBERT ALFANO ,  Cheng-hui Liu

IPC: A61B5/00 ,  A61B1/00 ,  A61B10/00 ,  A61B1/05 ,  A61B5/08 ,  A61B5/20 ,  A61B1/07 ,  A61B1/06

CPC classification number: A61B5/0075 ,  A61B1/00009 ,  A61B1/00082 ,  A61B1/00089 ,  A61B1/051 ,  A61B1/063 ,  A61B1/07 ,  A61B5/0042 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/0091 ,  A61B5/08 ,  A61B5/20 ,  A61B5/201 ,  A61B5/202 ,  A61B5/42 ,  A61B5/4306 ,  A61B5/4312 ,  A61B5/4318 ,  A61B5/7282 ,  A61B10/0041

Abstract: A method to detect vibrations associated with biomolecules in tissues and cellsuses Resonance Raman (RR) spectroscopy to measure specific biomolecules in tissue and cells signals. The changes of RR lines of key molecules present to the chemical conformations and change due to disease such as cancer and heart disease. Biomolecules are collagen, flavins, tryptophan, NADH, NAD, etc. The laser beams excite RR of vibration associated with absorption of the key native molecules in tissue (Tryptophan, NADH, Flavins, Collagen, carotenoids, porphyrins and others. The margin assessment and RR images in 2D and 3D regions are found by RR signals using position scanners. The intensity and the numbers of molecule fingerprints indicate the prescence of and the degree of the changes of chemical conformations.

Abstract translation: 检测与组织和细胞内的生物分子相关的振动的方法共振拉曼（RR）光谱法测量组织和细胞信号中的特定生物分子。 关键分子的RR线的变化由于诸如癌症和心脏病等疾病而呈现为化学构象和变化。 生物分子是胶原蛋白，黄素，色氨酸，NADH，NAD等。激光束激发与吸收组织中重要天然分子（色氨酸，NADH，Flavins，胶原，类胡萝卜素，卟啉等）相关的振动的RR，边缘评估和 使用位置扫描仪，通过RR信号发现2D和3D区域的RR图像，分子指纹的强度和数量表示化学构象的变化和变化程度。

公开(公告)号：US20170049328A1

公开(公告)日：2017-02-23

申请号：US15243607

申请日：2016-08-22

Applicant: Robert R. Alfano ,  Cheng-hui Liu ,  Vidyasagar Sriramoju

Inventor： Robert R. Alfano ,  Cheng-hui Liu ,  Vidyasagar Sriramoju

IPC: A61B5/00 ,  A61B5/02

CPC classification number: A61B5/0086 ,  A61B5/0075 ,  A61B5/02007 ,  A61B2562/0238

Abstract: Vulnerable plaque (VP) is the main cause of death from heart attacks. All currently available methods developed to diagnose VP lack sensitivity and or specificity and are still unable to identify VP. Our patent addresses the problem to diagnose VP in arteries. The teachings here disclose a vulnerable plaque optical analyzer (VPOA) and Imager (VOPAI) for monitoring arterial walls by measuring whether the fingerprint Raman spectrum of adipose (lipid) tissue using Resonance Raman (RR) and common Raman(R) signals of aortic intimal wall layer. The RR and R lines of lipid determine presentation of VP.

Abstract translation: 易受伤害的斑块（VP）是心脏病发作死亡的主要原因。 目前开发用于诊断VP的所有方法缺乏灵敏度和/或特异性，仍然无法识别VP。 我们的专利解决了诊断动脉中VP的问题。 这里的教导公开了通过使用共振拉曼（RR）和主动脉内膜的共同拉曼（R）信号测量脂肪（脂质）组织的指纹拉曼光谱来监测动脉壁的易损斑块光学分析仪（VPOA）和成像仪（VOPAI） 墙层。 脂质的RR和R线决定VP的呈现。

公开(公告)号：US10426349B2

公开(公告)日：2019-10-01

申请号：US15243391

申请日：2016-08-22

Applicant: Robert R. Alfano

Inventor： Robert R. Alfano ,  Cheng-hui Liu

IPC: A61B5/00 ,  A61B1/07 ,  A61B1/00 ,  A61B1/06 ,  A61B1/05 ,  A61B5/08 ,  A61B5/20 ,  A61B10/00

Abstract: A method to detect vibrations associated with biomolecules in tissues and cellsuses Resonance Raman (RR) spectroscopy to measure specific biomolecules in tissue and cells signals. The changes of RR lines of key molecules present to the chemical conformations and change due to disease such as cancer and heart disease. Biomolecules are collagen, flavins, tryptophan, NADH, NAD, etc. The laser beams excite RR of vibration associated with absorption of the key native molecules in tissue (Tryptophan, NADH, Flavins, Collagen, carotenoids, porphyrins and others. The margin assessment and RR images in 2D and 3D regions are found by RR signals using position scanners. The intensity and the numbers of molecule fingerprints indicate the presence of and the degree of the changes of chemical conformations.