公开(公告)号：US09952234B2

公开(公告)日：2018-04-24

申请号：US14966804

申请日：2015-12-11

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Martin Horstmann ,  Fridl Lang

IPC: G01N33/96 ,  G01N21/75 ,  G01N35/00 ,  G01J1/02 ,  G01N21/27 ,  G01N33/487

CPC classification number: G01N33/96 ,  G01J1/0295 ,  G01N21/274 ,  G01N21/75 ,  G01N33/487 ,  G01N35/00693 ,  G01N2201/12746 ,  G01N2496/00

Abstract: A method for determining a physical property of a biological sample. The method comprises the steps of: acquiring a set of preliminary calibration signals of a first lot of a reagent using an automatic analyzer with a first photometry module; acquiring a reference set of signals of the first lot of the reagent using a calibration analyzer with a second photometry module; determining a set of module specific components by subtracting the reference set of signals from the preliminary calibration signals; acquiring a lot specific set of signals of a second lot of the reagent using the second photometry module; determining a lot calibration for the first photometry module using the set of module specific components and the lot specific set of signals; acquiring a measurement signal of the biological sample using the first photometry module and the second lot of the reagent; and determining a physical property of the biological sample using the measurement signal and the lot calibration.

公开(公告)号：US20160097785A1

公开(公告)日：2016-04-07

申请号：US14966804

申请日：2015-12-11

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Martin Horstmann ,  Fridl Lang

IPC: G01N33/96 ,  G01N21/75 ,  G01J1/02 ,  G01N35/00

CPC classification number: G01N33/96 ,  G01J1/0295 ,  G01N21/274 ,  G01N21/75 ,  G01N33/487 ,  G01N35/00693 ,  G01N2201/12746 ,  G01N2496/00

Abstract: A method for determining a physical property of a biological sample. The method comprises the steps of: acquiring a set of preliminary calibration signals of a first lot of a reagent using an automatic analyzer with a first photometry module; acquiring a reference set of signals of the first lot of the reagent using a calibration analyzer with a second photometry module; determining a set of module specific components by subtracting the reference set of signals from the preliminary calibration signals; acquiring a lot specific set of signals of a second lot of the reagent using the second photometry module; determining a lot calibration for the first photometry module using the set of module specific components and the lot specific set of signals; acquiring a measurement signal of the biological sample using the first photometry module and the second lot of the reagent; and determining a physical property of the biological sample using the measurement signal and the lot calibration.

Abstract translation: 一种用于确定生物样品的物理性质的方法。 该方法包括以下步骤：使用具有第一测光模块的自动分析仪获取试剂的第一批次的一组初步校准信号; 使用具有第二测光模块的校准分析仪获取所述第一批试剂的参考信号集; 通过从所述初步校准信号中减去所述参考信号组来确定一组模块特定组件; 使用第二测光模块获取第二批试剂的许多特定信号集合; 使用所述一组模块特定组件和所述特定的信号集来确定所述第一测光模块的批量校准; 使用第一测光模块和第二批试剂获取生物样品的测量信号; 以及使用测量信号和批次校准来确定生物样品的物理性质。