公开(公告)号：US20220348858A1

公开(公告)日：2022-11-03

申请号：US17608062

申请日：2020-05-15

Applicant: SEKISUI CHEMICAL CO., LTD.

Inventor： Daigo KOBAYASHI ,  Mayumi YUKAWA ,  Kenta TAKAKURA ,  Ryoma ISHII ,  Hiroki IGUCHI ,  Yuuhei ARAI ,  Satoshi HANEDA ,  Nobuhiko INUI

IPC: C12M1/12 ,  C12N5/00 ,  C07K7/64 ,  C08F261/12 ,  C08J7/12 ,  C09D151/00

Abstract: Provided is a cell culture scaffold material having excellent cell adhesion. The cell culture scaffold material according to the present invention contains a peptide-conjugated polyvinyl alcohol derivative having a polyvinyl alcohol derivative portion and a peptide portion, and the peptide portion has a cyclic peptide skeleton.

公开(公告)号：US20250043241A1

公开(公告)日：2025-02-06

申请号：US18719092

申请日：2022-12-26

Applicant: SEKISUI CHEMICAL CO., LTD.

Inventor： Yuuhei ARAI ,  Daigo KOBAYASHI ,  Yoshito ARAI

IPC: C12N5/00

Abstract: Provided is a scaffold material for cell culture with which the culture stability of cells can be maintained over an extended period of time. A scaffold material for cell culture according to the present invention contains a peptide-conjugated (meth)acrylic copolymer having a (meth)acrylic copolymer moiety and a peptide moiety bonded to the (meth)acrylic copolymer moiety, when the peptide-conjugated (meth)acrylic copolymer is subjected to high performance liquid chromatography measurement under the following condition 1, a peak top of a main peak having the largest area among signals being not detected within a retention time of 4 minutes: the condition 1 being: a column of C18 (Inner diameter 3.0 mm×length 150 mm, filler particle size 3.5 μm), a column temperature of 40° C., a flow rate of 0.3 mL/min, a detector of an evaporative light scattering detector, a mobile phase A (liquid A) of a 0.1 wt % aqueous formic acid solution, a mobile phase B (liquid B) of isopropyl alcohol, a retention time of 0 minutes, in which the liquid A/the liquid B (volume ratio) is 70%/30%, a retention time of 0 minutes to 15 minutes, in which the liquid A/the liquid B (volume ratio) is changed from 70%/30% to 0%/100%, and a retention time of 15 minutes to 30 minutes, in which the liquid A/the liquid B (volume ratio)=0%/100% is maintained

公开(公告)号：US20250011475A1

公开(公告)日：2025-01-09

申请号：US18830103

申请日：2024-09-10

Applicant: SEKISUI CHEMICAL CO., LTD.

Inventor： Daigo KOBAYASHI ,  Yuuhei ARAI

IPC: C07K17/08 ,  C07K1/36

Abstract: Provided is a coating solution for forming a cell scaffold with which a cell scaffold having a large thickness can be easily formed and the proliferation of cells can be enhanced. A coating solution for forming a cell scaffold according to the present invention contains a peptide-conjugated resin having a synthetic resin moiety and a peptide moiety and an alcohol solvent, a content of the peptide-conjugated resin being 0.1 wt % or more.

公开(公告)号：US20250051722A1

公开(公告)日：2025-02-13

申请号：US18719129

申请日：2022-12-26

Applicant: SEKISUI CHEMICAL CO., LTD.

Inventor： Daigo KOBAYASHI ,  Yuuhei ARAI

IPC: C12N5/00

Abstract: Provided is a coating solution for forming a cell scaffold with which a cell scaffold having a large thickness can be easily formed and the proliferation of cells can be enhanced. A coating solution for forming a cell scaffold according to the present invention contains a peptide-conjugated resin having a synthetic resin moiety and a peptide moiety and an alcohol solvent, a content of the peptide-conjugated resin being 0.1 wt % or more.

公开(公告)号：US20220325221A1

公开(公告)日：2022-10-13

申请号：US17608008

申请日：2020-05-15

Applicant: SEKISUI CHEMICAL CO., LTD.

Inventor： Kenta TAKAKURA ,  Mayumi YUKAWA ,  Daigo KOBAYASHI ,  Ryoma ISHII ,  Hiroki IGUCHI ,  Yuuhei ARAI ,  Satoshi HANEDA ,  Nobuhiko INUI

IPC: C12M1/12 ,  C12M1/00 ,  C12N5/00

Abstract: Provided is a cell culture scaffold material having excellent extensibility of pseudopodia and excellent cell proliferation. The cell culture scaffold material according to the present invention contains a peptide-conjugated polyvinyl alcohol derivative having a polyvinyl alcohol derivative portion and a peptide portion, and has a hydroxyl value of 1,100 mgKOH/g or less.

公开(公告)号：US20220227898A1

公开(公告)日：2022-07-21

申请号：US17608044

申请日：2020-05-15

Applicant: SEKISUI CHEMICAL CO., LTD.

Inventor： Hiroki IGUCHI ,  Yuuhei ARAI ,  Nobuhiko INUI ,  Mayumi YUKAWA ,  Daigo KOBAYASHI ,  Yuuta NAKAMURA ,  Kenta TAKAKURA ,  Satoshi HANEDA ,  Ryoma ISHII

IPC: C08F20/12 ,  C12N5/00 ,  C07K7/06 ,  C08F16/06

Abstract: Provided is a resin film formed of a cell culture scaffold material, which has excellent fixation of cells after seeding and is capable of enhancing proliferation rate of cells. A resin film formed of a cell culture scaffold material, in which the cell culture scaffold material contains a synthetic resin, and the resin film has phase-separated structure including least a first phase and a second phase, and a ratio of the surface area of one of the first phase and the second phase to the entire surface is 0.01 or more and 0.95 or less.