公开(公告)号：US20220403432A1

公开(公告)日：2022-12-22

申请号：US17772359

申请日：2021-02-03

Applicant: SHANDONG UNIVERSITY

Inventor： Lian LI ,  Chen YU ,  Hengchang ZANG ,  Shuang QUAN ,  Yan LI ,  Fengshan WANG

IPC: C12P19/26 ,  G01N30/02

Abstract: A method for preparing chondroitin sulfate oligosaccharides with a C5 protein targeting property, and an application thereof, relating to the technical field of biomedicine. The method uses squid chondroitin sulfate as a raw material to prepare chondroitin sulfate oligosaccharides using enzymatic hydrolysis, using the method to screen the activity of various types of oligosaccharides in order to obtain the fragment with the best activity; the method is highly scientific and feasible. The method further uses the screened chondroitin sulfate disaccharides; the mechanism of chondroitin sulfate disaccharides in the treatment of osteoarthritis by regulating the complement system is explored and revealed by in vitro and in vivo experiments to finally provide a new way of treating osteoarthritis, thus having good practical application value.

公开(公告)号：US20200209316A1

公开(公告)日：2020-07-02

申请号：US16644329

申请日：2017-11-01

Applicant: SHANDONG UNIVERSITY

Inventor： Chenghui ZHANG ,  Zhongkai ZHOU ,  Bin DUAN ,  Yunlong SHANG ,  Yan LI ,  Naxin CUI

IPC: G01R31/367 ,  G01R31/36

Abstract: A new method for iteratively identifying parameters of an equivalent circuit model of battery, including the steps of: Firstly, dividing the model parameters into two parts, and the parameters in the first part are set to initial values, and the ones in the second part are identified with a least square method. Secondly, determining whether the obtained values of the second part meet the requirements of the equivalent circuit model of battery. If the requirements are not met, the parameters that do not meet the requirements in the second part are set to zeros. Then, the parameters in the first part are identified with the least square method. Otherwise, the ones in the first part are directly identified with the same method. Terminating the iteration process until all the parameters meet the requirements.