公开(公告)号：US20210291083A1

公开(公告)日：2021-09-23

申请号：US17196327

申请日：2021-03-09

Applicant: SHIBUYA CORPORATION

Inventor： Toshiaki NAKA ,  Shigeki KOISHI ,  Akira HATANAKA

IPC: B01D29/56 ,  B01D29/62 ,  B01D61/14

Abstract: A liquid containing exosomes is filtered through a first filter that has a hole diameter that passes the exosomes and blocks cells, and is then stored in a first storage unit (rough filtration step). Next, pressure is applied to the inside of the first storage unit to pump the liquid to a pre-filtration chamber in a second filter that blocks the exosomes so that water in the liquid is filtered out into a post-filtration chamber. The exosome-containing liquid that was not filtered out is returned to the first storage unit, thereby increasing the exosome concentration in the liquid for extraction (concentration step). The exosome-containing concentrate in the first storage unit is then filtered through a third filter having a hole diameter that passes the exosomes and blocks bacteria, and is sent to a recovery unit (sterilization filtration step).

公开(公告)号：US20180362202A1

公开(公告)日：2018-12-20

申请号：US16006278

申请日：2018-06-12

Applicant: SHIBUYA CORPORATION

Inventor： Toshiaki NAKA ,  Kei MATSUI ,  Tokuo NISHI ,  Masanari EJIRI ,  Noriaki IKENAGA

IPC: B65B55/24

Abstract: The present invention relates to a surface treatment method and a surface treatment device 2 for a resin vessel 1, which form a coating or perform surface modification on the surface of the resin vessel 1. In a sterilized environment as well as an environment with pressure equal to or higher than the atmospheric pressure, a material for the coating or the surface modification is attached to at least one of an inner surface and an outer surface of the resin vessel 1, and the resin vessel 1, to which the material is attached, is irradiated with an electron beam to perform the coating or the surface modification. It is possible to form the coating or perform the surface modification on the resin vessel at high speed.

公开(公告)号：US20180203327A1

公开(公告)日：2018-07-19

申请号：US15868164

申请日：2018-01-11

Applicant: SHIBUYA CORPORATION

Inventor： Toshiaki NAKA ,  Motoi SASAKI ,  Akito TSUCHIYA

IPC: G02F1/39 ,  G02F1/35

CPC classification number: G02F1/39 ,  G02F1/3501 ,  G02F2001/3503 ,  G02F2203/055 ,  G02F2203/13

Abstract: A pumping beam L1 enters from a pumping beam projector 3 into one end surface 2a of a nonlinear crystal 2, the pumping beam L1 and idler wave L2 are generated from another end surface 2b of the nonlinear crystal 2. The pumping beam L1 emitted from the other end surface 2b of the nonlinear crystal 2 is reflected and re-enters as a pumping beam L′ into the other end surface 2b and the idler wave L2 generated from the other end surface 2b of the nonlinear crystal is reflected by the reflection optical system 6 and re-enters as a seed beam L2′ into the other end surface 2b. The idler wave L2 enters as the seed beam L2′ together with the pumping beam L1′ into the nonlinear crystal and thus a terahertz wave with a large output and including a plurality of wavelengths can be generated.

公开(公告)号：US20170219911A1

公开(公告)日：2017-08-03

申请号：US15411086

申请日：2017-01-20

Applicant: SHIBUYA CORPORATION

Inventor： Kodo KAWASE ,  Toshiaki NAKA ,  Motoi SASAKI ,  Akito TSUCHIYA

IPC: G02F1/35 ,  G02F1/39

CPC classification number: G02F1/3501 ,  G02F1/3532 ,  G02F1/39 ,  G02F2001/3503 ,  G02F2001/3507 ,  G02F2001/392 ,  G02F2201/302 ,  G02F2203/13 ,  H01S3/0092 ,  H01S2302/02

Abstract: In a terahertz wave generation apparatus including a first non-linear optical crystal 3 on which first laser L1 and second laser L2 from laser generation means 2 are incident to generate terahertz wave TH1, the laser generation means includes a second non-linear optical crystal 7 on which laser having the same wavelength as that of the second laser is incident to generate idler light L1 including a plurality of wavelengths, and makes the idler light L1 generated from the second non-linear optical crystal incident on the first non-linear optical crystal as the first laser L1, to generate terahertz wave including a plurality of wavelengths from the first non-linear optical crystal 3, and wavelength selection means including a transmission section which transmits an idler light having the specific wavelength in the idler light including the plurality of wavelengths can be provided, as needed. Thus, terahertz wave having a high output power and including a plurality of wavelengths can be obtained, and the wavelength selection means easily obtains a required terahertz wave having the specific wavelength.

公开(公告)号：US20210130146A1

公开(公告)日：2021-05-06

申请号：US17053492

申请日：2019-04-17

Applicant: Keio University ,  SHIBUYA CORPORATION

Inventor： Takahiro NOZAKI ,  Kouhei OHNISHI ,  Toshiaki NAKA ,  Masato OHTA ,  Takaharu KIKURA

IPC: B67C3/20 ,  B67C3/22 ,  G01B21/08 ,  G01G7/00

Abstract: Weighing and filling apparatus for controlling filling device based on a container weight. A linear actuator for driving a drive shaft coupled to container support unit is included, a weight measuring unit determines the container weight from a detected height of the drive shaft detected by a height detecting unit and a drive signal of the linear actuator at the detected height. A first acceleration signal is calculated from a specified height of the container support unit set in advance and the height detected by the height detecting unit, a second acceleration signal is calculated from the container weight and an expected weight expected to be applied to the container support unit. The container support unit is kept at the specified height by a drive signal calculated from the first and second acceleration signals.

公开(公告)号：US20180149946A1

公开(公告)日：2018-05-31

申请号：US15815096

申请日：2017-11-16

Applicant: SHIBUYA CORPORATION

Inventor： Toshiaki NAKA ,  Motoi SASAKI ,  Akito TSUCHIYA

IPC: G02F1/39 ,  G02F1/35

CPC classification number: G02F1/39 ,  G02F1/3501 ,  G02F1/3534 ,  G02F1/3551 ,  G02F2001/3503 ,  G02F2203/13

Abstract: Pumping beam L1 is caused to be incident on an end surface 4A of a nonlinear crystal 4, and seed beam L2 the diameter of which is increased by a concave lens 6 is collected and adjusted into a collimated beam by a convex lens 7 and is caused to be incident on the end surface 4A described above. As described above, the pumping beam L1 and the seed beam L2 are caused to be incident on the end surface 4A with the pumping beam L1 and the seed beam L2 superimposed on each other, whereby the nonlinear crystal 4 generates terahertz wave TH.Since the diameter of the seed beam L2 described above is increased by the concave lens 6, the diameter of the seed beam L2 incident on the end surface 4A can be greater than the diameter of the seed beam generated by a terahertz wave generator of related art shown in FIG. 3. The area where the pumping beam L1 and the seed beam L2 incident on the end surface 4A are superimposed on each other can be greater than the area in the terahertz wave generator of related art.Since the area where the seed beam L2 and the pumping beam L1 are superimposed on each other on the end surface 4A can be greater than ever, the intensity of the terahertz wave TH generated by the nonlinear crystal 4 can be increased.

公开(公告)号：US20180143510A1

公开(公告)日：2018-05-24

申请号：US15801869

申请日：2017-11-02

Applicant: SHIBUYA CORPORATION

Inventor： Toshiaki NAKA ,  Motoi SASAKI ,  Akito TSUCHIYA

IPC: G02F1/39 ,  G02F1/35

CPC classification number: G02F1/39 ,  G02F1/3501 ,  G02F1/3534 ,  G02F1/3544 ,  G02F2001/3503 ,  G02F2203/13

Abstract: A terahertz wave generator 1 includes a nonlinear crystal 4, which is capable of generating terahertz wave TH, a pumping beam emitter 2, which emits pumping beam L1, a seed beam emitter 3, which is disposed so as to be parallel to the nonlinear crystal 4 and emits seed beam L2, a first total reflection mirror 17 and a second total reflection mirror 18, which successively reflect the seed beam L2 emitted from the seed beam emitter 3 to cause the seed beam L2 to be incident on the nonlinear crystal 4, and a convex lens 6, which collects the seed beam L2.When the pumping beam L1 and the seed beam L2 are caused to be incident on the nonlinear crystal 4 with the pumping beam L1 and the seed beam L2 superimposed on each other, the nonlinear crystal 4 generates the terahertz wave TH.Moving the first total reflection mirror 17 in the horizontal direction along the optical path of the seed beam L2 immediately after it is emitted can change the angle of incidence of the seed beam L2 incident on the nonlinear crystal 4. A terahertz wave generator 1 that is more compact and inexpensive than ever can be provided.