公开(公告)号：US20250084189A1

公开(公告)日：2025-03-13

申请号：US18724813

申请日：2022-12-30

Applicant: SIGILON THERAPEUTICS, INC.

Inventor： Matthew Buchanan ,  Omar De Paolis ,  Weiheng Wang

IPC: C08B37/00 ,  A61K9/00 ,  A61K9/50

Abstract: Described herein are polysaccharide polymers comprising a saccharide moiety modified with a hydroxyl-modifying agent (e.g., a saccharide monomer of Formula (I)), as well as related compositions, hydrogels, implantable elements, therapeutic substances, including enzymes, antibodies, hormones, or blood clotting factors. Further provided methods of treating a disease, disorder, or condition in a subject by administering to the subject an implantable element or a pharmaceutical composition.

公开(公告)号：US20230303502A1

公开(公告)日：2023-09-28

申请号：US18019664

申请日：2021-08-04

Applicant: SIGILON THERAPEUTICS, INC.

Inventor： Richard Heidebrecht ,  Christopher P. Hencken ,  Omar De Paolis ,  Weiheng Wang ,  Matthew Buchanan

IPC: C07D249/04 ,  C07D471/04 ,  C07D487/04 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14

CPC classification number: C07D249/04 ,  C07D471/04 ,  C07D487/04 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14

Abstract: Described herein are compounds of Formulas (I), (II), and (III) and pharmaceutically acceptable salts thereof, related compositions and preparations thereof, as well as methods of making and using the same.

公开(公告)号：US20250066512A1

公开(公告)日：2025-02-27

申请号：US18724811

申请日：2022-12-30

Applicant: SIGILON THERAPEUTICS, INC.

Inventor： Matthew Buchanan ,  Omar De Paolis ,  Weiheng Wang ,  Christopher P. Hencken

IPC: C08B37/00 ,  A61K9/00 ,  A61K9/48 ,  A61K47/61 ,  A61L31/04 ,  A61L31/14 ,  A61L31/16

Abstract: Described herein are polysaccharide polymers comprising a saccharide moiety modified with a hydroxyl-modifying agent (e.g., a saccharide monomer of Formula (I)), as well as related compositions, hydrogels, implantable elements, and methods of use thereof.