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公开(公告)号：US20220125784A1
公开(公告)日：2022-04-28
申请号：US17427949
申请日：2020-02-04
Applicant: SIMON FRASER UNIVERSITY
Inventor： Mena F. ABDELSAYED , Peter C. RUBEN
IPC: A61K31/498 , A61K31/4184
Abstract: The current application relates to compounds that bind and inhibit the inactivation of Navi.5 voltage-gated sodium channel (VGSC). The compounds can be used for treating cardiovascular diseases such as Brugada syndrome, cardiac arrhythmia disorder, progressive cardiac conduction disorder (PCCD), sick sinus syndrome, progressive familial block, atrial fibrillation, sudden infant death syndrome, dilated cardiomyopathy, myocardial ischemia/infarction, or heart failure.
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