公开(公告)号：US20170216252A1

公开(公告)日：2017-08-03

申请号：US15325602

申请日：2015-07-10

Applicant: SIMON FRASER UNIVERSITY ,  CENTRE FOR DRUG RESEARCH AND DEVELOPMENT

Inventor： Robert N. YOUNG ,  Nag Sharwan KUMAR ,  Christophe LABRIERE ,  Jon Paul SELVAN ,  James Brian JAQUITH ,  Edith Mary DULLAGHAN

IPC: A61K31/404 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/428 ,  A61K31/501 ,  A61K31/497 ,  A61K31/454 ,  A61K31/4184 ,  A61K31/4155 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/4178 ,  A61K31/422 ,  A61K31/437 ,  A61K31/427 ,  A61K31/506 ,  A61K45/06

CPC classification number: A61K31/404 ,  A61K31/405 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/422 ,  A61K31/427 ,  A61K31/428 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/497 ,  A61K31/501 ,  A61K31/505 ,  A61K31/506 ,  A61K31/5377 ,  A61K45/06 ,  C07D209/08 ,  C07D209/10 ,  C07D209/12 ,  C07D209/14 ,  C07D209/18 ,  C07D209/42 ,  C07D235/06 ,  C07D235/24 ,  C07D263/56 ,  C07D277/64 ,  C07D277/68 ,  C07D277/82 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/04 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D405/04 ,  C07D405/06 ,  C07D409/04 ,  C07D409/06 ,  C07D409/14 ,  C07D413/06 ,  C07D417/04 ,  C07D417/06 ,  C07D471/04 ,  Y02A50/401 ,  Y02A50/47 ,  Y02A50/471 ,  Y02A50/473 ,  Y02A50/475 ,  Y02A50/478 ,  Y02A50/481 ,  Y02A50/483

Abstract: Compounds of general formula I that are capable of inhibiting bacterial pyruvate kinase and/or bacterial growth. The compounds may find use as antibacterial agents in therapeutic and/or non-therapeutic contexts.

公开(公告)号：US20170029372A1

公开(公告)日：2017-02-02

申请号：US15302363

申请日：2015-04-09

Applicant: THE UNIVERSITY OF BRITISH COLUMBIA ,  SIMON FRASER UNIVERSITY

Inventor： Paul RENNIE ,  Artem TCHERKASSOV ,  Robert N. YOUNG ,  Christophe M. ANDRE

IPC: C07D209/14 ,  C07D231/56 ,  C07D471/04 ,  C07D405/14 ,  C07D235/30 ,  C07D209/30 ,  C07D209/08 ,  C07D209/42 ,  C07D405/12 ,  C07D235/18 ,  C07D413/04 ,  C07D401/06 ,  C07D417/04 ,  C07C243/22 ,  C07D403/04 ,  C07D401/04 ,  C07D209/10 ,  C07D417/10 ,  C07D413/10 ,  C07D401/10 ,  C07D417/14 ,  C07D403/14 ,  C07D209/34 ,  C07D277/82

CPC classification number: C07D209/14 ,  C07C243/22 ,  C07D209/08 ,  C07D209/10 ,  C07D209/30 ,  C07D209/34 ,  C07D209/42 ,  C07D231/56 ,  C07D235/18 ,  C07D235/30 ,  C07D277/82 ,  C07D401/04 ,  C07D401/06 ,  C07D401/10 ,  C07D403/04 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D413/04 ,  C07D413/10 ,  C07D417/04 ,  C07D417/10 ,  C07D417/14 ,  C07D471/04

Abstract: This invention provides compound having a structure of Formulas: Uses of such compounds for treatment of various indications, including prostate cancer as well as methods of treatment involving such compounds are also provide.

Abstract translation: 本发明提供具有以下结构的化合物：还提供了用于治疗各种适应症的这些化合物的用途，包括前列腺癌以及涉及这些化合物的治疗方法。

公开(公告)号：US20190300480A1

公开(公告)日：2019-10-03

申请号：US16426406

申请日：2019-05-30

Applicant: THE UNIVERSITY OF BRITISH COLUMBIA ,  SIMON FRASER UNIVERSITY

Inventor： Paul RENNIE ,  Artem TCHERKASSOV ,  Robert N. YOUNG ,  Christophe M. ANDRE

IPC: C07D209/14 ,  C07D235/18 ,  C07D231/56 ,  C07D277/82 ,  C07D417/10 ,  C07D401/10 ,  C07D401/06 ,  C07D405/12 ,  C07D405/14 ,  C07D413/04 ,  C07D413/10 ,  C07D417/04 ,  C07C243/22 ,  C07D209/08 ,  C07D209/10 ,  C07D209/30 ,  C07D209/34 ,  C07D209/42 ,  C07D471/04 ,  C07D417/14 ,  C07D403/14 ,  C07D403/04 ,  C07D401/04 ,  C07D235/30

Abstract: This invention provides compound having a structure of Formulas: Uses of such compounds for treatment of various indications, including prostate cancer as well as methods of treatment involving such compounds are also provide.

公开(公告)号：US20180170951A1

公开(公告)日：2018-06-21

申请号：US15735372

申请日：2016-06-13

Applicant: SIMON FRASER UNIVERSITY

Inventor： Marion THÉVENIN ,  Robert N. YOUNG ,  Gang CHEN

IPC: C07F9/572 ,  A61K47/54 ,  A61P19/08

CPC classification number: C07F9/572 ,  A61K47/548 ,  A61P19/08 ,  C07F9/3873

Abstract: The present invention relates to conjugate compounds and methods of making and using same.

公开(公告)号：US20220242893A1

公开(公告)日：2022-08-04

申请号：US17725689

申请日：2022-04-21

Applicant: SIMON FRASER UNIVERSITY

Inventor： Marion THÉVENIN ,  Robert N. YOUNG ,  Gang CHEN

IPC: C07F9/572 ,  C07F9/38 ,  A61K47/54 ,  A61P19/08

Abstract: The present invention relates to conjugate compounds and methods of making and using same.

公开(公告)号：US20210024464A1

公开(公告)日：2021-01-28

申请号：US16774814

申请日：2020-01-28

Applicant: THE UNIVERSITY OF BRITISH COLUMBIA ,  SIMON FRASER UNIVERSITY

Inventor： Paul RENNIE ,  Artem TCHERKASSOV ,  Robert N. YOUNG ,  Christophe M. ANDRE

IPC: C07D209/14 ,  C07D231/56 ,  C07D401/04 ,  C07D403/04 ,  C07D403/14 ,  C07D417/14 ,  C07D471/04 ,  C07C243/22 ,  C07D209/08 ,  C07D209/10 ,  C07D209/30 ,  C07D209/34 ,  C07D209/42 ,  C07D235/18 ,  C07D235/30 ,  C07D277/82 ,  C07D401/06 ,  C07D401/10 ,  C07D405/12 ,  C07D405/14 ,  C07D413/04 ,  C07D413/10 ,  C07D417/04 ,  C07D417/10

Abstract: This invention provides compound having a structure of Formulas: Uses of such compounds for treatment of various indications, including prostate cancer as well as methods of treatment involving such compounds are also provide.