公开(公告)号：US20250059140A1

公开(公告)日：2025-02-20

申请号：US18814472

申请日：2024-08-24

Applicant: SOUTHWEST JIAOTONG UNIVERSITY

Inventor： Xianli ZHOU ,  Shuai HUANG ,  Lin CHEN ,  Feng GAO

IPC: C07D221/24 ,  A61K36/714 ,  A61P9/04

Abstract: A C19 diterpenoid alkaloid represented by where R1 is hydrogen, methyl or ethyl; R2 is hydroxyl, methoxy or ethoxy; R3 is hydroxyl or methoxy; and R4 is hydroxyl or methoxy. The C19 diterpenoid alkaloid is prepared from a plant material belonging to the genus Aconitum of the family Ranunculaceae through extraction, concentration and separation using silica gel column chromatography. An application of the C19 diterpenoid alkaloid in the preparation of cardiotonic drugs and drugs for preventing and/or treating heart failure is also provided.

公开(公告)号：US20220281883A1

公开(公告)日：2022-09-08

申请号：US17746938

申请日：2022-05-17

Applicant: Southwest Jiaotong University

Inventor： Xianli ZHOU ,  Shuai HUANG ,  Feng GAO ,  Lin CHEN

IPC: C07D487/22 ,  C07F1/04 ,  C07F1/00 ,  A61P35/00

Abstract: A chlorin compound, and a preparation and use thereof, related to medicine. The chlorin compound is represented by formula (I), or a salt, a stereisomer, a hydrate, a solvate or a prodrug thereof.

公开(公告)号：US20220144779A1

公开(公告)日：2022-05-12

申请号：US17581920

申请日：2022-01-22

Applicant: Southwest Jiaotong University

Inventor： Xianli ZHOU ,  Feng GAO ,  Xiaohuan LI ,  Yuzhu LI ,  Shuai HUANG ,  Lin CHEN ,  Yinyong ZHANG

IPC: C07D223/32

Abstract: Provided herein are a lappaconitine derivative of formula (I), and a preparation and application thereof.