公开(公告)号：US20160193161A1

公开(公告)日：2016-07-07

申请号：US14911943

申请日：2014-08-14

Applicant: STC.UNM

Inventor： Jeff Wade HILL

IPC: A61K31/138 ,  A61K31/325 ,  A61K45/06 ,  A61K9/00

CPC classification number: A61K31/138 ,  A61K9/0019 ,  A61K31/27 ,  A61K31/325 ,  A61K45/06 ,  G01N33/5058 ,  A61K2300/00

Abstract: Using high-throughput screening, in an oxygen-glucose deprivation (OGD) model, isoxsuprine hydrochloride was identified as a potent neuroprotective compound. In an animal middle artery occlusion (MCAO) model of transient focal ischemia, isoxsuprine significantly reduced infarct volume compared to vehicle. The invention, therefore, provides methods of treatment and pharmaceutical compositions that are useful in the treatment and prevention of a wide-variety of ischemia-related injuries, including stroke.

Abstract translation: 使用高通量筛选，在氧 - 葡萄糖剥夺（OGD）模型中，将isoxsuprine盐酸盐鉴定为有效的神经保护性化合物。 在短暂性局灶性缺血的动物中动脉闭塞（MCAO）模型中，与载体相比，isoxsuprine显着降低了梗死体积。 因此，本发明提供了治疗和药物组合物的方法，其可用于治疗和预防各种与缺血相关的损伤，包括中风。