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公开(公告)号：US09943580B2
公开(公告)日：2018-04-17
申请号：US15023653
申请日：2014-09-11
Applicant: STC.UNM , LEIDOS, INC
Inventor： David S. Peabody , Bryce Chackerian , James Pannucci , Gabriel M. Gutierrez , Amy Rene Noe , Scott Budd Winram , Steve Chienwen Huang
CPC classification number: A61K39/015 , A61K35/76 , A61K39/39 , A61K2039/5256 , A61K2039/5258 , A61K2039/55566 , C07K2319/40 , C12N7/00 , C12N15/1037 , C12N2795/18122 , C12N2795/18123 , C12N2795/18134 , Y02A50/412
Abstract: Embodiments are directed to malaria vaccines comprising a bacteriophage VLP displaying a heterologous peptide identified by affinity selection as an anti-malaria mimotope.
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Patent Agency Ranking
公开(公告)号：US20160176955A1
公开(公告)日：2016-06-23
申请号：US15056458
申请日：2016-02-29
Applicant: Leidos, Inc. , The United States of America, as represented by the Secretary, Dept. of Health and Human Services
Inventor： Gabriel M. Gutierrez , James Pannucci , Amy Noe , Steve Chienwen Huang , Scott Winram , Annie Xiaoyan Mo
IPC: C07K16/20
CPC classification number: C07K16/205 , A61K39/015 , A61K39/39575 , A61K45/06 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/76 , Y02A50/412
Abstract: This disclosure provides antibodies that are useful for preventing and/or treating malaria. The epitope to which the antibodies bind is in close proximity to the conserved proteolytic cleavage site of P. falciparum circumsporozoite protein (CSP), and the antibodies provided in this disclosure can prevent cleavage and inhibit P. falciparum sporozoites from invading the liver.
Abstract translation: 本公开提供可用于预防和/或治疗疟疾的抗体。 抗体结合的表位紧邻恶性疟原虫环子孢子蛋白（CSP）的保守的蛋白水解切割位点，并且本公开中提供的抗体可以预防切割并抑制恶性疟原虫子孢子侵入肝脏。
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公开(公告)号：US20150158941A1
公开(公告)日：2015-06-11
申请号：US14097799
申请日：2013-12-05
Applicant: Leidos, Inc.
Inventor： Gabriel M. Gutierrez , James Pannucci , Amy Noe , Steve Chienwen Huang , Scott Winram
IPC: C07K16/20 , A61K45/06 , A61K39/395 , A61K39/015
CPC classification number: C07K16/205 , A61K39/015 , A61K39/39575 , A61K45/06 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/76 , Y02A50/412
Abstract: This disclosure provides antibodies that are useful for preventing and/or treating malaria. The epitope to which the antibodies bind is in close proximity to the conserved proteolytic cleavage site of P. falciparum circumsporozoite protein (CSP), and the antibodies provided in this disclosure can prevent cleavage and inhibit P. falciparum sporozoites from invading the liver.
Abstract translation: 本公开提供可用于预防和/或治疗疟疾的抗体。 抗体结合的表位紧邻恶性疟原虫环子孢子蛋白（CSP）的保守的蛋白水解切割位点，并且本公开中提供的抗体可以预防切割并抑制恶性疟原虫子孢子侵入肝脏。
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公开(公告)号：US20190002545A1
公开(公告)日：2019-01-03
申请号：US16133143
申请日：2018-09-17
Applicant: Leidos, Inc. , The United States of America, as represented by the Secretary, Dept. of Health and Human Services
Inventor： Gabriel M. Gutierrez , James Pannucci , Amy Noe , Steve Chienwen Huang , Scott Winram , Annie Xiaoyan Mo
IPC: C07K16/20 , A61K39/395 , A61K45/06 , A61K39/015
Abstract: This disclosure provides antibodies that are useful for preventing and/or treating malaria. The epitope to which the antibodies bind is in close proximity to the conserved proteolytic cleavage site of P. falciparum circumsporozoite protein (CSP), and the antibodies provided in this disclosure can prevent cleavage and inhibit P. falciparum sporozoites from invading the liver.
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公开(公告)号：US10160802B2
公开(公告)日：2018-12-25
申请号：US15056458
申请日：2016-02-29
Applicant: Leidos, Inc. , The United States of America, as represented by the Secretary, Dept. of Health and Human Services
Inventor： Gabriel M. Gutierrez , James Pannucci , Amy Noe , Steve Chienwen Huang , Scott Winram , Annie Xiaoyan Mo
IPC: A61K39/015 , C07H21/02 , A61K39/02 , C07K16/20 , A61K39/395 , A61K45/06 , A61K39/00
Abstract: This disclosure provides antibodies that are useful for preventing and/or treating malaria. The epitope to which the antibodies bind is in close proximity to the conserved proteolytic cleavage site of P. falciparum circumsporozoite protein (CSP), and the antibodies provided in this disclosure can prevent cleavage and inhibit P. falciparum sporozoites from invading the liver.
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公开(公告)号：US09321834B2
公开(公告)日：2016-04-26
申请号：US14097799
申请日：2013-12-05
Applicant: Leidos, Inc. , The United States of America, as represented by the Secretary, Dept. of Health and Human Services
Inventor： Gabriel M. Gutierrez , James Pannucci , Amy Noe , Steve Chienwen Huang , Scott Winram , Annie Xiaoyan Mo
IPC: A61K39/015 , A61K45/00 , A61K39/395 , C07K16/20 , A61K45/06 , A61K39/00
CPC classification number: C07K16/205 , A61K39/015 , A61K39/39575 , A61K45/06 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/76 , Y02A50/412
Abstract: This disclosure provides antibodies that are useful for preventing and/or treating malaria. The epitope to which the antibodies bind is in close proximity to the conserved proteolytic cleavage site of P. falciparum circumsporozoite protein (CSP), and the antibodies provided in this disclosure can prevent cleavage and inhibit P. falciparum sporozoites from invading the liver.
Abstract translation: 本公开提供可用于预防和/或治疗疟疾的抗体。 抗体结合的表位紧邻恶性疟原虫环子孢子蛋白（CSP）的保守的蛋白水解切割位点，并且本公开中提供的抗体可以预防切割并抑制恶性疟原虫子孢子侵入肝脏。
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