公开(公告)号：US20210052169A1

公开(公告)日：2021-02-25

申请号：US16997908

申请日：2020-08-19

Applicant: Stichting IMEC Nederland

Inventor： Evelien HERMELING ,  Eva WENTINK

IPC: A61B5/02 ,  A61B5/021 ,  A61B5/022 ,  A61B5/0225 ,  A61B5/0402 ,  A61B5/053

Abstract: The present invention provides a method for assessing at least one parameter related to the microcirculation function of a person, said method comprising the steps of a) determining an arrival time (AT) of a pulse wave, wherein the AT is the time between the onset of an activity of the heart that produces said pulse wave and the arrival of said pulse wave in a part of the body of said person; b) varying an applied pressure (P) on said part of the body over time and determining said AT as a function of applied pressure and time; and c) assessing said at least one parameter related to the microcirculation function based on said determination of AT and said AT as a function of applied pressure and time in steps a) and b). The present invention further provides a system for assessing at least one parameter related to the microcirculation function of a person.

公开(公告)号：US20250114617A1

公开(公告)日：2025-04-10

申请号：US18905255

申请日：2024-10-03

Applicant: Stichting IMEC Nederland

Inventor： Mark FICHMAN ,  Vojkan MIHAJLOVIC ,  Evelien HERMELING

IPC: A61N1/368

Abstract: An apparatus for controlling conduction of an electrical signal in a heart comprises: a stimulation generating unit; a first pair and a second pair of electrodes to be arranged in relation to a location in the heart, wherein an interferential stimulation signal is formed in the location based on first and second stimulation signals received by the first and second pairs of electrodes, wherein a difference between a first frequency of the first stimulation signal and a second frequency of the second stimulation signal defines a beat frequency of the interferential stimulation signal for controlling conduction of the electrical signal; an electrical signal sensor for detecting conduction of the electrical signal; and a control unit for controlling output of the first and the second stimulation signals for controlling timing of the interferential stimulation signal in relation to the electrical signal.

公开(公告)号：US20220361761A1

公开(公告)日：2022-11-17

申请号：US17240200

申请日：2021-04-26

Applicant: Stichting IMEC Nederland

Inventor： Fabian BEUTEL ,  Evelien HERMELING

IPC: A61B5/02 ,  A61B5/0285 ,  A61B5/021 ,  A61B5/00 ,  G16H50/30 ,  G16H50/70 ,  G16H10/60 ,  G16H40/67

Abstract: A method for estimating a measure of cardiovascular health of a subject comprises: receiving (106) time-based sequences of at least a first and a second artery signal, each representative of pressure pulse wave propagation in an artery and representing pressure pulse wave propagation in positions displaced in relation to each other in the artery; fitting (110) a first and a second waveform to a portion of the time-based sequences to form a first and a second waveform of the first artery signal and a first and a second waveform of the second artery signal, wherein the first waveforms represent a forward propagating wave and the second waveforms represent a backward propagating wave; and determining (112) at least one parameter based on the fitting, wherein the at least one parameter comprises a forward velocity of the pressure pulse wave propagation as a representation of local pulse wave velocity in the artery.

公开(公告)号：US20220400973A1

公开(公告)日：2022-12-22

申请号：US17844212

申请日：2022-06-20

Applicant: STICHTING IMEC NEDERLAND

Inventor： Lucas LINDEBOOM ,  Willemijn GROENENDAAL ,  Evelien HERMELING

IPC: A61B5/0537 ,  A61B5/00

Abstract: A method for estimating total body water, TBW, content of a subject, comprises: receiving locally measured bioimpedances for at least two different frequencies of a stimulation current at a body part of the subject; determining a first resistance and a second resistance of the bioimpedance, wherein the first resistance corresponds to a representation of the bioimpedance being purely resistive at a low frequency of the stimulation current and the second resistance corresponds to a representation of the bioimpedance being purely resistive at a high frequency of the stimulation current; and estimating the TBW content of the subject using a ratio between the first resistance and the second resistance.

公开(公告)号：US20220000378A1

公开(公告)日：2022-01-06

申请号：US17368648

申请日：2021-07-06

Applicant: Stichting IMEC Nederland

Inventor： Fabian BEUTEL ,  Evelien HERMELING

IPC: A61B5/021 ,  A61B8/06 ,  A61B5/0285 ,  A61B5/352 ,  A61B8/04 ,  A61B8/02 ,  A61B8/08 ,  G16H50/30 ,  G16H10/60 ,  G16H40/67

Abstract: A method for estimating a measure of cardiovascular health of a subject (102) comprises: receiving (302) an electrocardiogram, ECG, signal (202); receiving (304) an artery signal (210) representative of pressure pulse wave propagation at a location in an artery; determining (306) a fiducial point in time based on the ECG signal (202) providing an indication of onset of isovolumetric contraction; determining (308) a pre-systolic pressure pulse arrival point in time (212) based on the artery signal (210) to correspond to the onset of the isovolumetric contraction being reflected in the artery signal (210), determining (310) a time period between the onset of the isovolumetric contraction and the pre-systolic pressure pulse arrival point in time, said time period representing a vascular transit time; and determining (312) a pulse wave velocity of the subject (102) based on a physical distance between an aortic valve and the location in the artery and on the vascular transit time.