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    SYSTEMS AND METHODS FOR CONTINUOUS FLOW PCR SYSTEMS
    1.
    发明申请
    SYSTEMS AND METHODS FOR CONTINUOUS FLOW PCR SYSTEMS 审中-公开
    连续流动PCR系统的系统和方法

    公开(公告)号：US20160348190A1

    公开(公告)日：2016-12-01

    申请号：US15136679

    申请日：2016-04-22

    Applicant: STOKES BIO LIMITED

    Inventor： Mauro Aguanno ,  David Kinahan ,  Mark Korenke ,  Ryan Talbot ,  Mark Gaughran ,  Matthew Lough

    IPC: C12Q3/00 ,  B01L7/00 ,  G01N35/08 ,  C12Q1/68

    CPC classification number: C12Q3/00 ,  B01L7/5255 ,  B01L2300/0627 ,  C12Q1/686 ,  G01N35/08 ,  G01N2035/00366

    Abstract: A liquid handling system of a PCR system is instructed to obtain a matrix of samples and reagents for a PCR experiment. A fluid pumping system of the PCR system is instructed to maintain a continuous flow of a transport fluid through a plurality of micro-channels that allows the mixture of the samples and the reagents producing a plurality of mixed sample droplets. One or more post-bridge detection values are received from a post-bridge detection system of the PCR system for each mixed sample droplet to determine if the mixed sample droplet is mixed correctly. A thermocycler of the PCR system is instructed to maintain one or more temperatures for cycling the temperature of the plurality of mixed sample droplets. One or more endpoint detection values are received from an endpoint detection system of the PCR system for each mixed sample droplet to analyze the PCR experiment.

    Abstract translation: 指示PCR系统的液体处理系统获得用于PCR实验的样品和试剂的基质。 指示PCR系统的流体泵送系统保持运输流体通过多个微通道的连续流动，允许样品和试剂的混合物产生多个混合样品液滴。 从PCR系统的后桥检测系统接收每个混合样品液滴的一个或多个后桥检测值，以确定混合样品液滴是否被正确混合。 指示PCR系统的热循环仪保持用于循环多个混合样品液滴的温度的一个或多个温度。 从每个混合样品液滴的PCR系统的端点检测系统接收一个或多个端点检测值，以分析PCR实验。

    End-Point Optical System and Method of Use
    2.
    发明申请
    End-Point Optical System and Method of Use 审中-公开
    端点光学系统及其使用方法

    公开(公告)号：US20160340715A1

    公开(公告)日：2016-11-24

    申请号：US15162559

    申请日：2016-05-23

    Applicant: Stokes Bio Limited

    Inventor： Mauro Aguanno ,  Damian Curtin ,  Damien King

    IPC: C12Q1/68 ,  G01N21/25 ,  G01N21/55

    CPC classification number: C12Q1/686 ,  G01N21/253 ,  G01N21/55 ,  G01N21/6452 ,  G01N21/6486 ,  G01N2201/0631 ,  G01N2201/0638

    Abstract: Systems and methods are used to detect spectral and spatial information in a continuous flow PCR system. An incident beam of electromagnetic radiation is emitted using a laser. The incident beam is received from the laser and the incident beam is transformed into an incident line of electromagnetic radiation using a line generator. The incident line is received from the line generator using a tube array that includes one or more transparent tubes in fluid communication with one or more micro-channels. Reflected electromagnetic radiation is received from the tube array and the reflected electromagnetic radiation is focused using an imaging lens. The focused reflected electromagnetic radiation is received from the imaging lens and a spectral intensity is detected from the focused reflected electromagnetic radiation using a spectrograph. The focused reflected electromagnetic radiation is received from the imaging lens and a location of the spectral intensity is detected using an imager.

    Abstract translation: 系统和方法用于检测连续流PCR系统中的光谱和空间信息。 使用激光发射入射的电磁辐射光束。 从激光器接收入射光束，并且使用线发生器将入射光束变换成电磁辐射的入射线。 使用管阵列从线发生器接收入射线，该管阵列包括与一个或多个微通道流体连通的一个或多个透明管。 从管阵列接收反射的电磁辐射，并且使用成像透镜聚焦反射的电磁辐射。 从成像透镜接收聚焦的反射电磁辐射，并且使用光谱仪从聚焦的反射电磁辐射检测光谱强度。 从成像透镜接收聚焦的反射电磁辐射，并使用成像器检测光谱强度的位置。

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