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    AUTOMATED NUCLEIC ACID ANALYSIS SYSTEM
    4.
    发明申请
    AUTOMATED NUCLEIC ACID ANALYSIS SYSTEM 审中-公开
    自动核酸分析系统

    公开(公告)号：US20140356853A1

    公开(公告)日：2014-12-04

    申请号：US14167583

    申请日：2014-01-29

    Applicant: Samsung Electronics Co., Ltd.

    Inventor： Won-seok CHUNG ,  Kak Namkoong ,  Kyung-ho Kim ,  Chin-sung Park ,  Joon-ho Kim ,  Joon-sub Shim ,  Won-jong Jung

    IPC: C12Q3/00

    CPC classification number: C12Q3/00 ,  C12Q1/686 ,  C12Q2565/629

    Abstract: A nucleic acid analysis system comprising a seating area configured to receive a microfluidic cartridge; a pneumatic module configured to supply a pneumatic pressure or a vacuum to the cartridge when mounted on the seating area; a thermal module configured to control temperature in a predetermined portion of the cartridge when mounted on the seating area; an optic module positioned to irradiate light onto the cartridge when mounted on the seating area, and detect light generated or reflected from a sample inside the cartridge when mounted on the seating area; a fluid sensing module that determines whether a fluid in a predetermined portion of a cartridge mounted on the seating area is in a gaseous state or a liquid state; a scanning module that moves the optic module and the fluid sensing module relative to the seating area; and a control module that controls operations of the pneumatic module, the thermal module, the optic module, the fluid sensing module, and the scanning module, and processes and analyzes data received therefrom.

    Abstract translation: 一种核酸分析系统，包括配置成接收微流控盒的座位区域; 气动模块，其构造成当安装在所述座位区域时向所述盒提供气动压力或真空; 配置为当安装在座位区上时控制盒的预定部分中的温度的热模块; 定位成当安装在就座区上时将光照射到盒上的光学模块，以及当安装在座位区域上时，检测从盒内的样品产生或反射的光; 流体感测模块，其确定安装在所述就座区域上的盒的预定部分中的流体是处于气态还是液态; 扫描模块，其相对于所述座位区域移动所述光学模块和所述流体感测模块; 以及控制模块，其控制气动模块，热模块，光模块，流体感测模块和扫描模块的操作，并处理和分析从其接收的数据。

    MICROFLUIDIC SYSTEM FOR NUCLEIC ACID ANALYSIS
    5.
    发明申请
    MICROFLUIDIC SYSTEM FOR NUCLEIC ACID ANALYSIS 有权
    核酸分析微流控系统

    公开(公告)号：US20140206073A1

    公开(公告)日：2014-07-24

    申请号：US14074590

    申请日：2013-11-07

    Applicant: Samsung Electronics Co., Ltd.

    Inventor： Chin-sung Park ,  Kak Namkoong ,  Joon-sub Shim ,  Won-seok Chung ,  Kyung-ho Kim ,  Joon-ho Kim ,  Won-jong Jung

    IPC: C12Q1/68

    CPC classification number: C12Q1/686 ,  B01L3/5027 ,  B01L3/527 ,  B01L7/525 ,  B01L2200/025 ,  B01L2200/028 ,  B01L2200/0684 ,  B01L2200/10 ,  B01L2300/0672 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2400/0487 ,  B01L2400/0655 ,  B01L2400/0683 ,  B01L2400/086

    Abstract: A microfluidic system for analyzing nucleic acid, the microfluidic system including a reagent supply device including a sample chamber into which a sample can be injected, one or more reagent chambers for containing one or more reagents for extracting nucleic acid from the sample, and a waste chamber in which the used reagent can be discarded; a binding-lysis chamber in which cells are captured from the sample and lysed to form a cell lysate containing nucleic acid; plurality of particles for cell binding disposed in the binding-lysis chamber; a plurality of rehydration chambers into which the cell lysate formed in the binding-lysis chamber can be distributed and mixed with a nucleic acid amplification reagent to form an amplification reaction mixture; a plurality of amplification chambers in which a nucleic acid amplification reaction is performed on the amplification reaction mixture introduced from the plurality of rehydration chambers; and a flow channel system including an outlet and a plurality of inlets connected to the reagent supply device and forming an integrated fluid flow between the binding-lysis chamber, the rehydration chambers, and the amplification chambers.

    Abstract translation: 一种用于分析核酸的微流体系统，所述微流体系统包括试剂供应装置，其包括可以注入样品的样品室，用于容纳用于从样品中提取核酸的一种或多种试剂的一个或多个试剂室和废物 可以丢弃使用的试剂的室; 结合裂解室，其中细胞从样品中捕获并裂解以形成含有核酸的细胞裂解物; 用于细胞结合的多个颗粒设置在结合裂解室中; 多个再结合室，其中在结合 - 溶解室中形成的细胞裂解物可以与核酸扩增试剂分配并混合以形成扩增反应混合物; 多个扩增室，其中对从多个再水化室引入的扩增反应混合物进行核酸扩增反应; 以及流道系统，其包括连接到试剂供应装置的出口和多个入口，并且在结合 - 溶解室，再水化室和扩增室之间形成一体的流体流。

    Microfluidic device and method of manufacturing the same
    6.
    发明授权
    Microfluidic device and method of manufacturing the same 有权
    微流体装置及其制造方法

    公开(公告)号：US09321051B2

    公开(公告)日：2016-04-26

    申请号：US13890041

    申请日：2013-05-08

    Applicant: Samsung Electronics Co., Ltd.

    Inventor： Jae-young Kim ,  Won-jong Jung

    IPC: B01L99/00 ,  B01L3/00 ,  F16K99/00

    CPC classification number: B01L3/502738 ,  B01L2300/0816 ,  B01L2400/0655 ,  F16K99/0015 ,  F16K99/0059 ,  F16K2099/008 ,  F16K2099/0084

    Abstract: A microfluidic device comprising a first substrate including a micro-flow path and a valve seat protruding into the micro-flow path, a second substrate coupled to the first substrate and including a cavity aligned with the valve seat, and a valve gate film provided between the first substrate and the second substrate, such that the valve gate film opens and closes the micro-flow path with air pressure applied to the cavity, wherein a surface of the valve seat is separated from the valve gate film at the initial stage such that the micro-flow path is opened at the initial stage, and the valve gate film moves to be in contact with the surface of the valve seat so that the micro-flow path is closed when air pressure is applied to the cavity.

    Abstract translation: 一种微流体装置，包括包括微流道和突出到微流路中的阀座的第一衬底，与第一衬底相连并包括与阀座对准的空腔的第二衬底，以及设置在第一衬底之间的阀门膜 第一基板和第二基板，使得阀门薄膜通过施加到空腔的空气压力来打开和关闭微流道，其中阀座的表面在初始阶段与阀门膜分离，使得 微流路在初始阶段打开，阀门膜移动以与阀座的表面接触，使得当空气压力施加到空腔时微流路闭合。

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