公开(公告)号：US20020127626A1

公开(公告)日：2002-09-12

申请号：US10029184

申请日：2001-12-28

Applicant: Sensors for Medicine and Science, Inc.

Inventor： George Y. Daniloff ,  Aristotle G. Kalivretenos ,  Alexandre V. Nikolaitchik

IPC: C12Q001/54 ,  G01N033/00

CPC classification number: G01N33/533 ,  C07F5/025 ,  G01N33/542 ,  G01N33/582 ,  G01N33/66 ,  Y10T436/144444

Abstract: Compositions and methods for determining the presence or concentration of glucose in a sample which may also contain an alpha-hydroxy acid or a beta-diketone. The method uses a compound having at least two recognition elements for glucose, oriented such that the interaction between the compound and glucose is more stable than the interaction between the compound and the alpha-hydroxy acid or beta-diketone, such that the presence of the alpha-hydroxy acid or the beta-diketone does not substantially interfere with said determination.

公开(公告)号：US20020094586A1

公开(公告)日：2002-07-18

申请号：US09754219

申请日：2001-01-05

Applicant: Sensors for Medicine and Science, Inc.

Inventor： George Y. Daniloff ,  Aristotle G. Kalivretenos ,  Alexandre V. Nikolaitchik ,  Edwin F. Ullman

IPC: C07C069/76 ,  C07F005/04

CPC classification number: G01N33/66

Abstract: Disclosed are methods for detecting analytes with indicator systems which may undergo a molecular configurational change upon exposure to the analyte. The configurational change affects a detectable quality associated with the indicator system, thereby allowing detection of the presence or concentration of the analyte.

Abstract translation: 公开了用于用指示剂系统检测分析物的方法，所述指示剂体系在暴露于分析物时可能经历分子结构变化。 配置变化影响与指示剂系统相关的可检测质量，从而允许检测分析物的存在或浓度。