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公开(公告)号：US20250000941A1
公开(公告)日：2025-01-02
申请号：US18412867
申请日：2024-01-15
Applicant: Shandong University
Inventor： Xiaopeng QI , Rudi MAO , Tao XU , Hongwei PAN , Can HUANG , Zhen LI
Abstract: The present disclosure provides a recombinant protein for inducing cytoplasmic vacuolization cell death and use thereof, and belongs to the technical field of biomedicine. The present disclosure provides a recombinant protein for inducing cell death, where the recombinant protein is at least one selected from the group consisting of PorV, Lipocalin, and β-barrel; and the PorV has an amino acid sequence shown in SEQ ID NO: 1, the Lipocalin has an amino acid sequence shown in SEQ ID NO: 2, and the B-barrel has an amino acid sequence shown in SEQ ID NO: 3. In the present disclosure, the recombinant protein induces the formation of cytoplasmic vacuolization in various cells, thereby inducing the vacuolar cell death.
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