公开(公告)号：US20220119463A1

公开(公告)日：2022-04-21

申请号：US17421243

申请日：2020-01-09

Applicant: Spiber Inc.

Inventor： Keisuke MORITA ,  Yunosuke ABE ,  Hiroyuki NAKAMURA ,  Shota TOGASHI ,  Tetsuo ASAKURA

IPC: C07K14/435 ,  C12N15/63 ,  D01F4/02 ,  C12P21/02

Abstract: The present invention relates to a modified fibroin including a domain sequence represented by Formula 1: [(A)n motif-REP]m or Formula 2: [(A)n motif-REP]m-(A)n motif, and having a serine residue content rate of less than 5.5%.
[In Formula 1 and Formula 2, the (A)n motif represents an amino acid sequence consisting of 4 to 27 amino acid residues, and the number of alanine residues with respect to the total number of amino acid residues in the (A)n motif is 80% or more. REP represents an amino acid sequence consisting of 10 to 200 amino acid residues. m represents an integer of 10 to 300. The plurality of (A)n motifs may be the same amino acid sequence or different amino acid sequences. A plurality of REPs may be the same amino acid sequence or different amino acid sequences.]