公开(公告)号：US20190233481A1

公开(公告)日：2019-08-01

申请号：US16312357

申请日：2017-06-23

Applicant: Spiber Inc. ,  KOJIMA INDUSTRIES CORPORATION

Inventor： Keisuke MORITA ,  Koichi KOTAKA

IPC: C07K14/435

CPC classification number: C07K14/43518 ,  C07K14/435 ,  C07K19/00 ,  C12N5/10 ,  C12N15/09

Abstract: The present invention relates to a modified fibroin including a domain sequence represented by Formula 1: [(A)n motif-REP]m, in which the domain sequence has an amino acid sequence locally containing a region with locally high hydropathy index equivalent to an amino acid sequence in which one or a plurality of amino acid residues in REP are substituted with amino acid residues with a high hydropathy index and/or one or a plurality of amino acid residues with a high hydropathy index are inserted into REP, as compared to naturally occurring fibroin. In Formula 1, (A)n motif represents an amino acid sequence consisting of 4 to 20 amino acid residues and the number of alanine residues relative to the total number of amino acid residues in the (A)n motif is 83% or more. REP represents an amino acid sequence consisting of 10 to 200 amino acid residues. m represents an integer of 10 to 300, A plurality of (A)n motifs and the like may be the same amino acid sequence or different amino acid sequences.

公开(公告)号：US20220010460A1

公开(公告)日：2022-01-13

申请号：US17427895

申请日：2020-02-07

Applicant: Spiber Inc.

Inventor： Yunosuke ABE ,  Hideto ISHII ,  Ryoko SATO ,  Akito SATO ,  Hirotada ANDO ,  Hiroshi KANO ,  Koichi KOTAKA ,  Jun KOBAYASHI

IPC: D01F4/02 ,  C07K14/435 ,  D01D5/06 ,  D02G3/04

Abstract: An object of the present invention is to provide a method for producing a modified fibroin multifilament excellent in productivity and a multifilament produced by the same. The multifilament of the present invention contains modified fibroin, in which the multifilament has 100 or more constituent single yarns, a coefficient of variation in elastic modulus is 15% or less, a coefficient of variation in strength is 15% or less, and a coefficient of variation in elongation is less than 33%.