公开(公告)号：US20220378871A1

公开(公告)日：2022-12-01

申请号：US17765342

申请日：2020-09-30

Applicant: Spiber Inc. ,  National University Corporation Tokai National Higher Education and Research System

Inventor： Hiroo Uchida ,  Hizuru Nagata ,  Akinari Hinoki ,  Masataka Fujii ,  Yun-Hsiang Chang ,  Satoshi Harada ,  Takehiro Sato

IPC: A61K38/17 ,  A61K47/20 ,  A61P21/06

Abstract: To provide a muscle tissue-regenerating agent containing a fibroin protein.
A muscle tissue-regenerating agent containing a modified fibroin protein.

公开(公告)号：US20220235099A1

公开(公告)日：2022-07-28

申请号：US17614058

申请日：2020-05-28

Applicant: Spiber Inc.

Inventor： Hironari Kamikubo ,  Yugo Hayashi ,  Takehiro Sato

IPC: C07K14/435 ,  D01F4/02

Abstract: Provided is a structural protein microbody that functions as a core for forming a protein nanofiber. There is provided a structural protein microbody including a structural protein, in which the structural protein microbody satisfies at least two of the following (i) to (iii): (i) a peak is present within a range of 480 to 500 nm in a fluorescence intensity measurement by thioflavin T staining; (ii) a peak is present in a region where Q is 0.15 or less in a modified Kratky plot of small angle X-ray scattering (SAXS); and (iii) the structural protein microbody is an aggregate of two or more structural protein molecules.