公开(公告)号：US20140286925A1

公开(公告)日：2014-09-25

申请号：US14295798

申请日：2014-06-04

Applicant: Syntaxin Limited

Inventor： Frederic MADEC ,  Philip LECANE ,  Philip MARKS ,  Keith FOSTER

IPC: C12N9/50

CPC classification number: C12N9/50 ,  A61K38/4893 ,  A61K47/60 ,  A61K47/6415 ,  C07K14/4756 ,  C07K14/485 ,  C07K14/495 ,  C07K14/50 ,  C07K14/503 ,  C07K14/52 ,  C07K14/522 ,  C07K14/5412 ,  C07K14/65 ,  C07K14/705 ,  C07K2319/50 ,  C07K2319/55 ,  C07K2319/74 ,  C12N9/52

Abstract: The present invention relates to polypeptides for use in suppressing cancer and cancer disorders. The treatment employs use of a non-cytotoxic protease, which is targeted to the cancer cell, and, when so delivered, the protease is internalised and inhibits secretion from the cancer cell.

Abstract translation: 本发明涉及用于抑制癌症和癌症疾病的多肽。 该治疗使用靶向癌细胞的非细胞毒性蛋白酶，并且当这样递送时，蛋白酶被内化并且抑制癌细胞的分泌。

公开(公告)号：US20140302006A1

公开(公告)日：2014-10-09

申请号：US14250959

申请日：2014-04-11

Applicant: Syntaxin Limited

Inventor： Steven JOHNSTONE ,  Philip MARKS ,  Keith FOSTER

IPC: C12N9/52

CPC classification number: C12N9/52 ,  A61K38/00 ,  C07K2319/035 ,  C07K2319/06 ,  C12P21/06

Abstract: The present invention relates to a method for suppressing neuroendocrine disease. The therapy employs use of a non-cytotoxic protease, which is targeted to a neuroendocrine tumour cell, preferably via a somatostatin or cortistatin receptor, a GHRH receptor, a ghrelin receptor, a bombesin receptor, a urotensin receptor a melanin-concentrating hormone receptor 1; a KiSS-1 receptor or a prolactin-releasing peptide receptor. When so delivered, the protease is internalised and inhibits secretion from said tumour cell. The present invention also relates to polypeptides and nucleic acids for use in said methods.

Abstract translation: 本发明涉及抑制神经内分泌疾病的方法。 该疗法使用非细胞毒性蛋白酶，其优选靶向神经内分泌肿瘤细胞，优选经由生长抑素或皮质抑素受体，GHRH受体，生长素释放肽受体，铃蟾肽受体，泌尿生素受体，黑色素浓缩激素受体1 ; KiSS-1受体或催乳素释放肽受体。 当这样传递时，蛋白酶被内化并且抑制来自所述肿瘤细胞的分泌。 本发明还涉及用于所述方法的多肽和核酸。

公开(公告)号：US20140219983A1

公开(公告)日：2014-08-07

申请号：US14250954

申请日：2014-04-11

Applicant: Syntaxin Limited

Inventor： Frederic MADEC ,  Phil LECANE ,  Philip MARKS ,  Keith FOSTER

IPC: C12N9/50 ,  C07K14/60 ,  C07K14/33 ,  C07K14/82 ,  C07K7/08 ,  C07K14/48 ,  C07K14/575 ,  C07K14/65

Abstract: The present invention relates to a method for suppressing or treating cancer, in particular to a method for suppressing or treating one or more of colorectal cancer, breast cancer, prostate cancer and/or lung cancer. The therapy employs use of a non-cytotoxic protease, which is targeted to a growth hormone-secreting cell such as to a pituitary cell. When so delivered, the protease is internalised and inhibits secretion/transmission of growth hormone from said cell. The present invention also relates to polypeptides and nucleic acids for use in said methods.

Abstract translation: 本发明涉及抑制或治疗癌症的方法，特别涉及抑制或治疗结肠直肠癌，乳腺癌，前列腺癌和/或肺癌中的一种或多种的方法。 该疗法使用非细胞毒性蛋白酶，其靶向生长激素分泌细胞，例如垂体细胞。 当这样传递时，蛋白酶被内化并且抑制生长激素从所述细胞的分泌/传递。 本发明还涉及用于所述方法的多肽和核酸。