Abstract:
Some embodiments are directed to a method for detaching tissue from a tissue section on a tissue slide. The method may include applying a 3D printed mask on top of the tissue section, the mask comprising barriers that define a cavity surrounding an area of interest on the tissue section, the cavity being open at a side facing the area of interest on the tissue section, dispensing a detaching liquid to the cavity, and allowing the detaching liquid to detach tissue at the area of interest, and aspirating the detaching liquid with the detached tissue from the cavity, and forwarding the liquid for further processing.
Abstract:
A pipette tip extension having a proximal end, a distal end, and an exterior wall extending between the proximal end and the distal end is disclosed. The exterior wall has an outer side and an inner side and encloses an inner cavity which is delimited by the inner side of the exterior wall. The exterior wall forms at the proximal end a reception aperture. The pipette tip extension further has one or more distance elements arranged at the inner side of the exterior wall and protruding into the inner cavity.
Abstract:
A storage device for storing one or more pipettor consumables contains a storage plate having an upper side and a lower side, and, on the upper side, a number of accommodation seats arranged in an array. Each accommodation seat is configured to receive a pipettor consumable in an upside-down orientation. The storage device has one or more positioning elements for positioning the storage device in relation to a carrier, and/or one or more stacking elements for stacking the storage device with another storage device.
Abstract:
A displacement device for displacing a displacement volume is disclosed. The device has a first fluid space and a second fluid space. A first piston is arranged in a movable manner within the first fluid space. The first fluid space is connectable to a pipetting device. The first piston is actuatable by an actuation volume of air or of liquid provided by the pipetting device. A second piston is arranged in a movable manner within the second fluid space. The second piston is constructed to displace a displacement volume of a fluid located within the second fluid space when the second piston is actuated. The second piston is actuated in dependence on the first piston that is actuated by the actuation volume. The actuation volume is different from the displacement volume, and a pipetting system has a displacement device and a method of displacing a displacement volume.
Abstract:
A cover (10) for use in a digital microfluidics system (16) for manipulating samples in liquid portions or droplets. The digital microfluidics system (16) includes a first substrate (18) with an array of electrodes (24) and a central control unit (20) for controlling the selection and for providing a number of the electrodes with voltage for manipulating liquid portions or droplets by electrowetting. A working gap (30) with a gap height is located parallel to the array of electrodes (24) and in-between first and second hydrophobic surfaces (26,28) that face each other at least during operation of the digital microfluidics system (16).
Abstract:
A pipette tip adapter (1) is detachably connectable between a pipetting device (10) and a pipette tip (15). The pipette tip adapter has a body (2) with an interior compartment (7) for holding a liquid (18), a recess (3) entering into a part of the body (2) for detachably receiving a connector (11) of the pipetting device (10) and having a first opening (5) pneumatically connected with the interior compartment (7). The pipette tip adapter (1) further has a tube section (4) projecting from the pipette tip adapter (1) detachably securable with a pipette tip (15) and having a second opening (6) hydraulically connected with the interior compartment (7). The pipette tip adapter (1) may be used in an automated pipetting system (100). An automated pipetting system (100) having a pipette tip adapter (1) for preparing liquid reactions is also disclosed.
Abstract:
A cover for a fluid container having an essentially plane cover plate for closing at least one opening of at least one fluid container and at least two ports, and each port has a through channel extending through the entire thickness of the cover plate and a fluid impermeable first membrane is arranged over the entire cross section of the through channel of the first port and an at least gas permeable second membrane is arranged over the entire cross section of the through channel of the second port is disclosed.
Abstract:
A pipette tip extension attachable to a pipette tip having a proximal end, a distal end, and an exterior wall extending between the proximal end and the distal end is disclosed. The exterior wall has an outer side and an inner side and forms at the proximal end a reception aperture for inserting a pipette tip, and at the distal end a dispense aperture. The pipette tip extension further has an inner cavity, a distance element connected to the inner side of the exterior wall, and a constriction element.
Abstract:
A centrifugal processing unit for directing the movement of substances within a sample processing cartridge having a rotor for receiving the sample processing cartridge, a rotor drive to create a centrifugal force, the centrifugal processing unit having a pivot accommodation and a fix accommodation for receiving the sample processing cartridge that are arranged on the rotor, where each pivot accommodation being adapted to allow a free pivoting motion of the received sample processing cartridge about a respective pivot axis, and each pivot axis being orthogonal to the rotor axis to the respective force vector of the centrifugal force.
Abstract:
A pipette tip extension attachable to a pipette tip with the pipette tip extension having a proximal end, a distal end, and exterior wall extending between the proximal end and the distal end is disclosed. The exterior wall having an outer side and inner side and forming at the proximal end a reception aperture for inserting a pipette tip, and at a distal end a dispense aperture. An inner cavity is enclosed by the inner side of the exterior wall and one or more distance elements connected to the inner side of the exterior wall. The distance element(s) being configured to position a pipette tip within the inner cavity and to establish fluid uptake area adjacent the inner side of the exterior wall with the fluid uptake area extending from the dispense aperture towards the reception aperture and being in fluid connection with the surrounding atmosphere at the reception aperture.