公开(公告)号：US3830223A

公开(公告)日：1974-08-20

申请号：US29018372

申请日：1972-09-18

Applicant: TECHNICON INSTR

Inventor： BERETSKY I ,  LICHTENSTEIN B

IPC: A61B8/00 ,  A61B8/08 ,  A61B5/02 ,  A61B10/00

CPC classification number: A61B8/0858

Abstract: New and improved methodology and apparatus for non-invasive biophysical diagnosis are disclosed and comprise the ensonification of body parts with multi-frequency energy pulses in predetermined timed sequence, the detection of the resultant echo pulses, the processing of the latter to provide signals indicative of the impedance of the body part, the referencing of said signals to the biophysical cycle of the body part, and the real time display of said signals in the form of an impedance profile of said body part.

Abstract translation: 公开了用于非侵入性生物物理诊断的新的和改进的方法和装置，并且包括以预定的定时序列与多频能量脉冲的身体部分的融合，所产生的回波脉冲的检测，后者的处理以提供指示 身体部位的阻抗，所述信号对身体部位的生物物理循环的参照，以及所述身体部位的阻抗曲线形式的所述信号的实时显示。

公开(公告)号：US3752443A

公开(公告)日：1973-08-14

申请号：US3752443D

申请日：1971-12-13

Applicant: TECHNICON INSTR

Inventor： LICHTENSTEIN B

IPC: G01N33/86 ,  B01F13/08 ,  G01N33/49 ,  G01N35/00 ,  G01N21/24

CPC classification number: B01F13/0809 ,  G01N33/4905 ,  G01N35/0098

Abstract: A magnetic mixer for laboratory use which includes a permanent magnet mounted for rotation and driven on an axis centrally between its poles. A volume of combined liquids, containing in addition a multiplicity of magnetic particles, is supported centrally with reference to the magnet poles for activation of the particles in the rotating magnetic field to mix the liquids to achieve a reaction between them or merely a blending. This rotational force on the mixture has the effect of redistributing the magnetic particles away from the center of the mixture which effect, unless countered, lessens the mixing action. A second permanent magnet is provided having its poles in substantial alignment with the first mentioned axis, and having one of these last-mentioned poles spaced a distance nearer to the mixture than the other pole thereof, the magnetic field of the second magnet being substantially at right angles to the magnetic field of the first magnet. The field of the second magnet effectively counters by attraction the aforementioned redistributing movement of the magnetic particles, and the resultant particle distribution is substantially uniform throughout the combined liquids.

Abstract translation: 一种用于实验室使用的磁力搅拌器，其包括永磁体，该永久磁铁安装成用于旋转并在轴之间的轴线上驱动。 另外还含有多个磁性颗粒的混合液体的量相对于用于激活旋转磁场中的颗粒的磁极被中心地支撑以混合液体以实现它们之间的反应或仅仅是混合。 混合物上的这种旋转力具有将磁性颗粒重新分布离开混合物中心的作用，除非有所反应，否则会降低混合作用。 提供第二永久磁铁，其极点与第一个提到的轴基本对齐，并且这些最后提到的磁极之一与其混合物的另一个极点相隔一定距离，第二磁体的磁场基本上位于 与第一磁体的磁场成直角。 第二磁体的场通过吸引上述磁性颗粒的再分布运动而有效地反应，并且所得到的颗粒分布在整个组合液体中基本上是均匀的。

公开(公告)号：US3843326A

公开(公告)日：1974-10-22

申请号：US26054972

申请日：1972-06-07

Applicant: TECHNICON INSTR

Inventor： LICHTENSTEIN B

IPC: B01F5/00 ,  G01N1/18 ,  G01N35/00 ,  G01N35/08 ,  G01N35/10 ,  B65B1/04 ,  B65B3/04 ,  G01N31/00

CPC classification number: G01N1/18 ,  G01N35/00 ,  G01N35/1079 ,  G01N2035/1032

Abstract: 1. APPARATUS FOR THE SUCCESSIVE MIXING OF A SERIES OF SAMPLES WITH A REAGENT WITHOUT INTER-SAMPLE CONTAMINATION COMPRISING, ELONGATED TUBING MEANS, MEANS FOR MOVING SAID TUBING MEANS ALONG A PATH, MEANS DISPOSED ALONG SAID PATH FOR SUCCESSIVELY SEALING SAID TUBING MEANS AT SPACED POINTS THEREON TO FORM SUCCESSIVE, SPACED SEALED TUBING VOLUMES WHICH ARE ISOLATED EACH FROM THE OTHER, MEANS FOR PUNCTURING SAID TUBING MEANS VOLUMES, AND MEANS FOR SUPPLYING PREDETERMINED SAMPLE AND REAGENT QUANTITIES INTO SAID TUBING MEANS VOLUMES DURING THE FORMATION THEREOF AND THROUGH PUNCTURES DEFINED THEREIN TO RESULT IN SPACED TUBING MEANS VOLUMES EACH CONTAINING A SAMPLE-REAGENT MIXTURE, SAID TUBING MEANS MOVING MEANS AND SAID MEANS TO FORM SAID SPACED TUBING MEANS SEALS BEING COOPERATIVELY EFFECTIVE TO EXPAND SAID TUBING MEANS VOLUMES DURING THE FORMATION THEREOF WHEREBY SAID SAMPLE AND REAGENT QUANTITIES MAY BE DRAWN THEREINTO THROUGH SAID PUNCTURES DURING THE TUBING MEANS VOLUME FORMATION.

公开(公告)号：US3709791A

公开(公告)日：1973-01-09

申请号：US3709791D

申请日：1971-04-13

Applicant: TECHNICON INSTR

Inventor： LICHTENSTEIN B

IPC: A61B5/145 ,  A61M3/00 ,  G01N33/48 ,  G01N33/49 ,  G01N35/00 ,  C12K1/00

CPC classification number: G01N33/491 ,  G01N35/0098 ,  Y10T436/255

Abstract: NEW AND IMPROVED METHOD AND APPARAYTUS FOR THE SEPARATION OF LYMPHOCYTES FROM WHOLE BOLLD SAMPLES UNDER STERILE CONDITIONS ARE PROVIDED AND COMPRISE STERILE, DISPOSABLE SYRINGE MEANS IN WHICH ARE MIXED LAND INCUBATED A BLOOD SAMPLE AND A SEPARATING AGENT. THE LATTER INCLUDES SENSITIZED MAGNETIC PARTICLES WHICH THE EFFECTIVE TO TAG THE BLOOD SAMPLE LEUKOCYTES TO THE SUBSTANTIAL EXCLUSION OF THE LYMPHOCYTES, AND AN ERYTHROCYTE SEDIMENTING AGENT WHICH IS EFFECTIVE TO PROMOTE THE SETTLING OF THE BLOOD SAMPLE ERYTHROYTES. FOLLOWING MIXTURE INCUBATION AND SETTLING IN THE SYRINGE, THE SAME IS OPERATIVELY POSITIONED ON SAMPLE TRANSFER AND MAGNETIC SEPARATOR MEANS WHICH INCLUDES A STERILE, DISPOSABLE SAMPLE TRANSFER TUBE AND AN OPERATIVELY ASSOCIATED MAGNETIC SEPARATOR. THE MIXTURE IS PUMPED AT SUBSTANTIALLY CONSTANT FLOW RATE FROM SAID SYRINGE, BY AUTOMATIC ACTUATION OF THE SYRINGE PLUNGER, FOR FLOW THROUGH SAID OPERATIVELY ASSOCIATED TRANSFER TUBE AND MAGNETIC SEPARATOR WITH RESULTANT SUBSTANTIAL RETENTION OF THE TAGGED LEUKOCYTES THEREIN AND CONTINUED FLOW OF THE LYMPHOCYTES IN THE PLASMA THROUGH THE REMAINDER OF THE TRANSFER TUBE TO LYMPHOCYTE COLLECTION MEANS.