公开(公告)号：US20220096318A1

公开(公告)日：2022-03-31

申请号：US17497796

申请日：2021-10-08

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Ronald M. Harper ,  Eberhardt K. Sauerland

IPC: A61H23/02 ,  A61H21/00 ,  A61M21/00

Abstract: A device for stimulating at least one cranial nerve and/or spinal nerve is described. The device includes a vibratory motor, and an earpiece, wherein the earpiece is molded substantially to fit within the external ear canal and contacting the concha of a subject's ear. The present invention provides a method of reducing migraine headache, trigeminal neuropathy pain, normalize breathing, normalize blood pressure, induce sleep, increase salivation, improve vertigo, nausea, and visual dysfunction. A method for non invasive neuromodulation includes the steps of positioning a vibratory earpiece within an external ear canal of a subject, applying vibrational energy through the vibratory earpiece to stimulate mechanoreceptors of sensory fibers on cranial nerves 5, 7, 9 and 10, and cervical nerves C2 and C3, and regulating the subject's breathing and blood pressure simultaneously based on the stimulation. Further, the present invention provides a method for treating sleep-disturbed breathing and autonomic disorders.

公开(公告)号：US20190192378A1

公开(公告)日：2019-06-27

申请号：US16100362

申请日：2018-08-10

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Ronald M. Harper ,  Eberhardt K. Sauerland

IPC: A61H23/02 ,  A61H21/00 ,  A61M21/00

CPC classification number: A61H23/02 ,  A61H21/00 ,  A61H2201/0107 ,  A61H2201/0184 ,  A61H2201/5002 ,  A61H2201/5005 ,  A61H2201/501 ,  A61H2201/5012 ,  A61H2201/5097 ,  A61H2205/027 ,  A61M21/00 ,  A61M2021/0022 ,  A61M2205/18 ,  A61M2205/3553 ,  A61M2205/3584 ,  A61M2205/3592 ,  A61M2210/0662

Abstract: A device for stimulating at least one cranial nerve and/or spinal nerve is described. The device includes a vibratory motor, and an earpiece, wherein the earpiece is molded substantially to fit within the external ear canal and contacting the concha of a subject's ear. A method of reducing migraine headache and trigeminal neuropathy pain is also described. The method includes positioning a vibratory earpiece within an ear of a subject, applying vibrational energy to at least a portion of the skin of at least one of the auditory canal, auricle and concha of the ear, thereby stimulating at least one sensory fiber of at least one of cranial nerve 5, cranial nerve 7, cranial nerve 9, cranial nerve 10, spinal nerve C2, and spinal nerve C3. A method to normalize breathing, normalize blood pressure, induce sleep, increase salivation, and improve vertigo, nausea, and visual dysfunction accompanying migraine is also described.

公开(公告)号：US20150141879A1

公开(公告)日：2015-05-21

申请号：US14546784

申请日：2014-11-18

Applicant: The Regents of the University of California

Inventor： Ronald M. Harper ,  Eberhardt K. Sauerland

IPC: A61H23/02

CPC classification number: A61H23/02 ,  A61H21/00 ,  A61H2201/0107 ,  A61H2201/0184 ,  A61H2201/5002 ,  A61H2201/5005 ,  A61H2201/501 ,  A61H2201/5012 ,  A61H2201/5097 ,  A61H2205/027 ,  A61M21/00 ,  A61M2021/0022 ,  A61M2205/18 ,  A61M2205/3553 ,  A61M2205/3584 ,  A61M2205/3592 ,  A61M2210/0662

Abstract: A device for stimulating at least one cranial nerve and/or spinal nerve is described. The device includes a vibratory motor, and an earpiece, wherein the earpiece is molded substantially to fit within the external ear canal and contacting the concha of a subject's ear. A method of reducing migraine headache and trigeminal neuropathy pain is also described. The method includes positioning a vibratory earpiece within an ear of a subject, applying vibrational energy to at least a portion of the skin of at least one of the auditory canal, auricle and concha of the ear, thereby stimulating at least one sensory fiber of at least one of cranial nerve 5, cranial nerve 7, cranial nerve 9, cranial nerve 10, spinal nerve C2, and spinal nerve C3. A method to normalize breathing, normalize blood pressure, induce sleep, increase salivation, and improve vertigo, nausea, and visual dysfunction accompanying migraine is also described.

Abstract translation: 描述了用于刺激至少一个颅神经和/或脊神经的装置。 该装置包括振动马达和耳机，其中耳机被模制成基本上适合于外耳道内并且接触被检者耳朵的耳朵。 还描述了减少偏头痛和三叉神经痛疼痛的方法。 该方法包括将振动耳机定位在受试者的耳朵内，将振动能量施加到至少一部分耳朵的耳道，耳廓和耳朵的皮肤的皮肤中，由此刺激至少一种感觉纤维 至少一个颅神经5，颅神经7，颅神经9，颅神经10，脊神经C2和脊神经C3。 还描述了一种使呼吸正常化，使血压正常化，诱导睡眠，增加唾液分泌并改善伴随偏头痛的眩晕，恶心和视觉功能障碍的方法。

公开(公告)号：US20230277411A1

公开(公告)日：2023-09-07

申请号：US18047032

申请日：2022-10-17

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Ronald M. Harper ,  Eberhardt K. Sauerland

IPC: A61H23/02 ,  A61H21/00 ,  A61M21/00

CPC classification number: A61H23/02 ,  A61H21/00 ,  A61M21/00 ,  A61H2201/0184 ,  A61H2201/5002 ,  A61H2201/5005 ,  A61H2201/501 ,  A61H2201/5012 ,  A61H2201/5097 ,  A61M2021/0022 ,  A61M2205/18 ,  A61M2205/3553 ,  A61M2205/3584 ,  A61M2205/3592 ,  A61M2210/0662 ,  A61H2201/0107 ,  A61H2205/027

Abstract: A device for stimulating at least one cranial nerve and/or spinal nerve is described. The device includes a vibratory motor, and an earpiece, wherein the earpiece is molded substantially to fit within the external ear canal and contacting the concha of a subject's ear. A method of reducing migraine headache and trigeminal neuropathy pain is also described. The method includes positioning a vibratory earpiece within an ear of a subject, applying vibrational energy to at least a portion of the skin of at least one of the auditory canal, auricle and concha of the ear, thereby stimulating at least one sensory fiber of at least one of cranial nerve 5, cranial nerve 7, cranial nerve 9, cranial nerve 10, spinal nerve C2, and spinal nerve C3. A method to normalize breathing, normalize blood pressure, induce sleep, increase salivation, and improve vertigo, nausea, and visual dysfunction accompanying migraine is also described.

公开(公告)号：US11471372B2

公开(公告)日：2022-10-18

申请号：US16100362

申请日：2018-08-10

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Ronald M. Harper ,  Eberhardt K. Sauerland

IPC: A61H23/02 ,  A61H21/00 ,  A61M21/00

Abstract: A device for stimulating at least one cranial nerve and/or spinal nerve is described. The device includes a vibratory motor, and an earpiece, wherein the earpiece is molded substantially to fit within the external ear canal and contacting the concha of a subject's ear. A method of reducing migraine headache and trigeminal neuropathy pain is also described. The method includes positioning a vibratory earpiece within an ear of a subject, applying vibrational energy to at least a portion of the skin of at least one of the auditory canal, auricle and concha of the ear, thereby stimulating at least one sensory fiber of at least one of cranial nerve 5, cranial nerve 7, cranial nerve 9, cranial nerve 10, spinal nerve C2, and spinal nerve C3. A method to normalize breathing, normalize blood pressure, induce sleep, increase salivation, and improve vertigo, nausea, and visual dysfunction accompanying migraine is also described.

公开(公告)号：US10045907B2

公开(公告)日：2018-08-14

申请号：US14546784

申请日：2014-11-18

Applicant: The Regents of the University of California

Inventor： Ronald M. Harper ,  Eberhardt K. Sauerland

IPC: A61H23/00 ,  A61H23/02 ,  A61H21/00 ,  A61M21/00

Abstract: A device for stimulating at least one cranial nerve and/or spinal nerve is described. The device includes a vibratory motor, and an earpiece, wherein the earpiece is molded substantially to fit within the external ear canal and contacting the concha of a subject's ear. A method of reducing migraine headache and trigeminal neuropathy pain is also described. The method includes positioning a vibratory earpiece within an ear of a subject, applying vibrational energy to at least a portion of the skin of at least one of the auditory canal, auricle and concha of the ear, thereby stimulating at least one sensory fiber of at least one of cranial nerve 5, cranial nerve 7, cranial nerve 9, cranial nerve 10, spinal nerve C2, and spinal nerve C3. A method to normalize breathing, normalize blood pressure, induce sleep, increase salivation, and improve vertigo, nausea, and visual dysfunction accompanying migraine is also described.

公开(公告)号：US11684540B2

公开(公告)日：2023-06-27

申请号：US16819642

申请日：2020-03-16

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Ronald M. Harper ,  Mary Ann Woo ,  Sergey Shaboyan ,  Paul Macey

IPC: A61H23/00 ,  A61H23/04 ,  A61F5/56 ,  A61H39/00 ,  A61H31/00 ,  A61M16/00 ,  A61H23/02

CPC classification number: A61H23/04 ,  A61F5/56 ,  A61H23/02 ,  A61H31/00 ,  A61H39/007 ,  A61M16/00 ,  A61H2201/164 ,  A61H2201/165 ,  A61H2201/1635 ,  A61H2201/501 ,  A61H2201/5002 ,  A61H2201/5005 ,  A61H2201/5038 ,  A61H2201/5097 ,  A61M2205/056 ,  A61M2205/332 ,  A61M2205/3569 ,  A61M2205/3592 ,  A61M2205/8206 ,  A61M2210/08 ,  A61M2230/42

Abstract: A device, system and method for increasing air intake by a subject is described. The device includes a vibration motor and a control unit for controlling vibrational motion output by the vibration motor. The methods include positioning the vibration motor on one or more limbs of a subject, and stimulating nerves in the limbs via the generated vibrational motion, whereby the stimulated nerve signals the brain to increase breathing rate or air intake by the subject. Accordingly, embodiments of the device activate nerve fibers that carry kinesthetic cues from the limbs in a pattern that simulates normal limb motion, and thus triggers inherent reflexes that increase ventilation in response to such motion.

公开(公告)号：US20200214934A1

公开(公告)日：2020-07-09

申请号：US16819642

申请日：2020-03-16

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Ronald M. Harper ,  Mary Ann Woo ,  Sergey Shaboyan ,  Paul Macey

IPC: A61H23/04 ,  A61F5/56 ,  A61H39/00 ,  A61H31/00 ,  A61M16/00 ,  A61H23/02

Abstract: A device, system and method for increasing air intake by a subject is described. The device includes a vibration motor and a control unit for controlling vibrational motion output by the vibration motor. The methods include positioning the vibration motor on one or more limbs of a subject, and stimulating nerves in the limbs via the generated vibrational motion, whereby the stimulated nerve signals the brain to increase breathing rate or air intake by the subject. Accordingly, embodiments of the device activate nerve fibers that carry kinesthetic cues from the limbs in a pattern that simulates normal limb motion, and thus triggers inherent reflexes that increase ventilation in response to such motion.

公开(公告)号：US20160158097A1

公开(公告)日：2016-06-09

申请号：US14906684

申请日：2014-07-22

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Ronald M. Harper ,  Mary Ann Woo ,  Sergey Shaboyan ,  Paul Macey

IPC: A61H23/04 ,  A61F5/56

Abstract: A device, system and method for increasing air intake by a subject is described. The device includes a vibration motor and a control unit for controlling vibrational motion output by the vibration motor. The methods include positioning the vibration motor on one or more limbs of a subject, and stimulating nerves in the limbs via the generated vibrational motion, whereby the stimulated nerve signals the brain to increase breathing rate or air intake by the subject. Accordingly, the device of the present invention activates nerve fibers that carry kinesthetic cues from the limbs in a pattern that simulates normal limb motion, and thus triggers inherent reflexes that increase ventilation in response to such motion.

Abstract translation: 描述了用于增加受试者的空气摄取量的装置，系统和方法。 该装置包括振动马达和用于控制由振动马达输出的振动运动的控制单元。 所述方法包括将振动马达定位在受试者的一个或多个肢体上，并且通过产生的振动运动来刺激肢体中的神经，由此刺激的神经发信号通知大脑以增加受试者的呼吸频率或空气摄取量。 因此，本发明的装置以模拟正常肢体运动的模式激活携带肢体运动刺激的神经纤维，从而触发响应于这种运动而增加通气的固有反射。